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Cited by 63Stress Responses and CortisolNeuroendocrine regulation and behaviorChild Abuse and Trauma

Altered corticosterone levels and social play behavior after prolonged maternal separation in adolescent male but not female Wistar rats.

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Lundberg, Stina, Martinsson, My, Nylander, Ingrid, Roman, Erika·2017·Hormones and Behavior
DOI 10.1016/j.yhbeh.2016.11.016
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Abstract

Early-life socio-environmental factors are crucial for normal developmental processes; adverse experiences early in life can therefore lead to detrimental effects in several physiological systems. The aim of this study was to examine short-term effects of early adverse experiences in a maternal separation (MS) rodent model. In this study two separation conditions were used: daily 15- (MS15) or 360-min (MS360) separation of the litter from the dam during postnatal day 1-21. In early adolescence, male and female offspring were subjected to a single-isolation procedure with analysis of corticosterone levels prior to and after isolation. In addition, social play behavior was assessed during mid-adolescence. There was a clear difference between male and female offspring in both tests performed. There was no difference in corticosterone levels between the female MS groups, whereas MS360 males showed higher baseline and recovery corticosterone levels than MS15 males. The amount of pinning, a specific social play behavior, was affected by rearing with MS360 males having a higher frequency than MS15 males, while there was no difference between the female MS groups. The observation that males but not females are affected by MS360 has previously been reported for adult animals, and herein we show that this difference is present already in adolescence. Changes in corticosterone levels and social behavior following early-life adversity have been associated with adult behavioral alterations, and our results confirm that these changes emerge already within adolescence.

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  • In rats, 3-6 h of daily maternal separation in the first 2 or 3 weeks of life either increased, decreased, or did not affect play behavior.

    “In rats, 3–6 h of daily maternal separation in the first 2 or 3 weeks of life either increased (Veenema and Neumann, 2009; Zimmerberg and Sageser, 2011; Lundberg et al., 2017), decreased (Muhammad and Kolb, 2011), or did not affect (Arnold and Siviy, 2002) play behavior.”

    From Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood (2018) · cites this paper as Lundberg et al., 2017

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Cited by

Sorted by citations

Authors
Lundberg, S., Martinsson, M., Nylander, I., & Roman, E.
Affiliations
Uppsala University (SE)
Corresponding author
Lundberg, Stina
ORCID
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
2017-01
Volume
87
Pages
137-144
ISSN
0018-506X (ISSN-L)
DOI
10.1016/j.yhbeh.2016.11.016
OpenAlex
W2555294804
Cited by
63
References
6
Citations by year
2026: 4 · 2025: 5 · 2024: 3 · 2023: 9 · 2022: 7 · 2021: 11 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 4
FWCI
3.41
Type
journal article
Language
en
Open access
Licence
Locations
  • Hormones and Behavior (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
Funders
  • Vetenskapsrådet
  • Systembolaget Aktiebolag
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords
maternal separation, corticosterone, social play, childhood adversity, adolescence, sex differences, Wistar rats, hypothalamic-pituitary-adrenal axis, postnatal development
MeSH terms
Animals, Animals, Newborn, Behavior, Animal, Corticosterone, Female, Male, Maternal Deprivation, Play and Playthings, Sex Characteristics, Sexual Maturation, Social Behavior, Time Factors, Rats, Wistar, Rats

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