Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis

Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1986) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.38.cp21 · Cited by 2,287 · see citing works

Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus

Meaney, M. J., Aitken, D. H., van Berkel, C., Bhatnagar, S., & Sapolsky, R. M. (1988) · Science · doi:10.1126/science.3340858 · Cited by 1,074 · see citing works

Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response.

Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.19.6174 · Cited by 758 · see citing works

Infantile Experience and Resistance to Physiological Stress

Levine, S. (1957) · Science · doi:10.1126/science.126.3270.405 · Cited by 659 · see citing works

Physiological and behavioral effects of infantile stimulation

Levine, S., Haltmeyer, G. C., Karas, G. G., & Denenberg, V. H. (1967) · Physiology & Behavior · doi:10.1016/0031-9384(67)90011-x · Cited by 545 · see citing works

Surgical Disconnection of the Medial Basal Hypothalamus and Pituitary Function in the Rhesus Monkey. I. Gonadotropin Secretion1,2

Krey, L. C., Butler, W. R., & Knobil, E. (1975) · Endocrinology · doi:10.1210/endo-96-5-1073 · Cited by 473 · see citing works

Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis

Herman, J. P., Schafer, M., Young, E. A., Thompson, R. C., DOUGLASS, J. O., Akil, H., & Watson, S. J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-09-03072.1989 · Cited by 467 · see citing works

Neonatal Handling Alters Adrenocortical Negative Feedback Sensitivity and Hippocampal Type II Glucocorticoid Receptor Binding in the Rat

Meaney, M. J., Aitken, D. H., Viau, V., Sharma, S., & Sarrieau, A. (2008) · Neuroendocrinology · doi:10.1159/000125287 · Cited by 457 · see citing works

Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions.

Meaney, M. J., Aitken, D. H., Bodnoff, S. R., Iny, L. J., Tatarewicz, J. E., & Sapolsky, R. M. (2013) · Behavioral Neuroscience · doi:10.1037/a0034187 · Cited by 307 · see citing works

Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions.

Meaney, M. J., Aitken, D. H., Bodnoff, S. R., Iny, L. J., Tatarewicz, J. E., & Sapolsky, R. M. (1985) · Behavioral Neuroscience · doi:10.1037/0735-7044.99.4.765 · Cited by 295 · see citing works

Simple Method of Harvesting <i>Limnoria</i> from Nature

Johnson, F. H., & Ray, D. L. (1962) · Science · doi:10.1126/science.135.3506.795-a · Cited by 276 · see citing works

Effects of Adrenalectomy and Dexamethasone Administration on the Level of Prepro-Corticotropin-Releasing Factor Messenger Ribonucleic Acid (mRNA) in the Hypothalamus and Adrenocorticotropin/β-Lipotropin Precursor mRNA in the Pituitary in Rats*

Jingami, H., Matsukura, S., Numa, S., & Imura, H. (1985) · Endocrinology · doi:10.1210/endo-117-4-1314 · Cited by 271 · see citing works

Thermal control of mother-young contact in rats

Leon, M., Croskerry, P. G., & Smith, G. K. (1978) · Physiology & Behavior · doi:10.1016/0031-9384(78)90021-5 · Cited by 250 · see citing works

Endocrine responses to mother‐infant separation in developing rats

Kuhn, C. M., Pauk, J. S., & Schanberg, S. M. (1990) · Developmental Psychobiology · doi:10.1002/dev.420230503 · Cited by 242 · see citing works

Basal ACTH, Corticosterone and Corticosterone-Binding Globulin Levels over the Diurnal Cycle, and Age-Related Changes in Hippocampal Type I and Type II Corticosteroid Receptor Binding Capacity in Young and Aged, Handled and Nonhandled Rats

Meaney, M. J., Aitken, D. H., Sharma, S., & Viau, V. (2008) · Neuroendocrinology · doi:10.1159/000126116 · Cited by 205 · see citing works

Increased plasma ACTH responses to stress in nonhandled compared with handled rats require basal levels of corticosterone and are associated with increased levels of ACTH secretagogues in the median eminence

Viau, V., Sharma, S., Plotsky, P. M., & Meaney, M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-01097.1993 · Cited by 181 · see citing works

Regulation of the Messenger Ribonucleic Acid for Corticotropin-Releasing Factor in the Paraventricular Nucleus and Other Brain Sites of the Rat*

BEYER, H. S., Matta, S. G., & Sharp, B. M. (1988) · Endocrinology · doi:10.1210/endo-123-4-2117 · Cited by 169 · see citing works

Modification of the corticosterone response curve as a function of handling in infancy

Hess, J. L., Denenberg, V. H., ZARROW, M. X., & Pfeifer, W. (1969) · Physiology & Behavior · doi:10.1016/0031-9384(69)90023-7 · Cited by 160 · see citing works

Postnatal development and environmental regulation of hippocampal glucocorticoid and mineralocorticoid receptors

Sarrieau, A., Sharma, S., & Meaney, M. J. (1988) · Developmental Brain Research · doi:10.1016/0165-3806(88)90162-9 · Cited by 150 · see citing works

Thyroid Hormones Influence the Development of Hippocampal Glucocorticoid Receptors in the Rat: A Mechanism for the Effects of Postnatal Handling on the Development of the Adrenocortical Stress Response

Meaney, M. J., Aitken, D. H., & Sapolsky, R. M. (2008) · Neuroendocrinology · doi:10.1159/000124741 · Cited by 147 · see citing works

Glucocorticoid Feedback Inhibition of Adrenocorticotropic Hormone Secretagogue Release

Sapolsky, R. M., Armanini, M. P., Packan, D. R., Sutton, S. W., & Plotsky, P. M. (2008) · Neuroendocrinology · doi:10.1159/000125357 · Cited by 145 · see citing works

Evidence for Multifactor Regulation of the Adrenocorticotropin Secretory Response to Hemodynamic Stimuli*

Plotsky, P. M., BRUHN, T. O., & Vale, W. (1985) · Endocrinology · doi:10.1210/endo-116-2-633 · Cited by 141 · see citing works

Effects of early experience on adrenocortical reactivity

Ader, R., & Grota, L. J. (1969) · Physiology & Behavior · doi:10.1016/0031-9384(69)90179-6 · Cited by 140 · see citing works

The role of serotonin in the development and environmental regulation of type II corticosteroid receptor binding in rat hippocampus

Mitchell, J. B., Iny, L. J., & Meaney, M. J. (1990) · Developmental Brain Research · doi:10.1016/0165-3806(90)90204-c · Cited by 139 · see citing works

Surgical Disconnection of the Medial Basal Hypothalamus and Pituitary Function in the Rhesus Monkey. II. GH and Cortisol Secretion12

Krey, L. C., Lu, K. H., Butler, W. R., HOTCHKISS, J., PIVA, F., & Knobil, E. (1975) · Endocrinology · doi:10.1210/endo-96-5-1088 · Cited by 130 · see citing works

Inhibition of Immunoreactive Corticotropin-Releasing Factor Secretion into the Hypophysial-Portal Circulation by Delayed Glucocorticoid Feedback*

Plotsky, P. M., Otto, S., & Sapolsky, R. M. (1986) · Endocrinology · doi:10.1210/endo-119-3-1126 · Cited by 119 · see citing works

Regulation of basal ACTH secretion by corticosterone is mediated by both type I (MR) and type II (GR) receptors in rat brain

Bradbury, M. J., Akana, S. F., Cascio, C. S., Levin, N., Jacobson, L., & Dallman, M. F. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90176-6 · Cited by 96 · see citing works

Administration of dexamethasone prior to training blocks ACTH-induced recovery of an extinguished avoidance response.

Ahlers, S. T., & Richardson, R. (1985) · Behavioral Neuroscience · doi:10.1037//0735-7044.99.4.760 · Cited by 65 · see citing works

Widespread expression of corticotropin-releasing factor messenger RNA and immunoreactivity in the rat olfactory bulb.

Imaki, T., Nahon, J., Sawchenko, P., & Vale, W. (1989) · Brain Research · doi:10.1016/0006-8993(89)91050-0 · Cited by 61 · see citing works

Handling in Infancy: Increased Levels of the Hypothalamic Corticotropin Releasing Factor (CRF) Following Exposure to a Novel Situation

ZARROW, M. X., Campbell, P. S., & Denenberg, V. H. (1972) · Experimental Biology and Medicine · doi:10.3181/00379727-141-36776 · Cited by 60 · see citing works

Effect of axonal transport blockade on corticotropin-releasing factor immunoreactivity in the median eminence of intact and adrenalectomized rats: relationship between depletion rate and secretory activity

BERKENBOSCH, F., & Tilders, F. J. H. (1988) · Brain Research · doi:10.1016/0006-8993(88)91517-x · Cited by 50 · see citing works

Child abuse: Adolescent records vs. adult recall

Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse &amp; Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820 · see citing works

The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology

Anda, R. F., Felitti, V. J., Bremner, J. D., Walker, J. D., Whitfield, C., Perry, B. D., Dube, S. R., & Giles, W. H. (2006) · European archives of psychiatry and clinical neuroscience · doi:10.1007/s00406-005-0624-4 · Cited by 4,292 · see citing works

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress

Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170 · see citing works

The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791 · see citing works

Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations

Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708 · see citing works

Brain corticosteroid receptor balance in health and disease

de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614 · see citing works

Neural consequences of enviromental enrichment

van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works

The Corticosteroid Receptor Hypothesis of Depression

Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181 · see citing works

The Neurocircuitry of Fear, Stress, and Anxiety Disorders

Shin, L. M., & Liberzon, I. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.83 · Cited by 2,083 · see citing works

Biological sensitivity to context: I. An evolutionary-developmental theory of the origins and functions of stress reactivity

BOYCE, W. T., & ELLIS, B. J. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050145 · Cited by 2,078 · see citing works

Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood

Heim, C. (2000) · JAMA · doi:10.1001/jama.284.5.592 · Cited by 1,968 · see citing works

Chronic stress, drug use, and vulnerability to addiction

Sinha, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.030 · Cited by 1,904 · see citing works

The effects of childhood maltreatment on brain structure, function and connectivity

Teicher, M. H., Samson, J. A., Anderson, C. M., & Ohashi, K. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.111 · Cited by 1,856 · see citing works

Allostasis and Allostatic Load Implications for Neuropsychopharmacology

McEwen, B. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00129-3 · Cited by 1,833 · see citing works

How does stress increase risk of drug abuse and relapse?

Sinha, R. (2001) · Psychopharmacology · doi:10.1007/s002130100917 · Cited by 1,505 · see citing works

Assessment of positive emotions in animals to improve their welfare

Boissy, A., Manteuffel, G., Jensen, M. B., Moe, R. O., Spruijt, B., Keeling, L. J., Winckler, C., Forkman, B., Dimitrov, I., Langbein, J., et al. (2007) · Physiology &amp; Behavior · doi:10.1016/j.physbeh.2007.02.003 · Cited by 1,486 · see citing works

Physiological stress in ecology: lessons from biomedical research

Romero, L. M. (2004) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2004.03.008 · Cited by 1,440 · see citing works

The role of corticotropin-releasing factor in depression and anxiety disorders

Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378 · see citing works

Brain on stress: how the social environment gets under the skin

McEwen, B. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121254109 · Cited by 1,200 · see citing works

Sexual abuse and lifetime diagnosis of psychiatric disorders: Systematic review and meta-analysis

Chen, L. P., Murad, M. H., Paras, M. L., Colbenson, K. M., Sattler, A. L., Goranson, E. N., Elamin, M. B., Seime, R. J., Shinozaki, G., Prokop, L. J., et al. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2009.0583 · Cited by 1,056 · see citing works

The oxytocin receptor: from intracellular signaling to behavior

Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works

The stress system in the human brain in depression and neurodegeneration

Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.003 · Cited by 984 · see citing works

Schizophrenia: A neural diathesis-stress model.

Walker, E. F., & Diforio, D. (1997) · Psychological Review · doi:10.1037//0033-295x.104.4.667 · Cited by 930 · see citing works

Prenatal Stress, Glucocorticoids and the Programming of the Brain

Welberg, L., & Seckl, J. R. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00601.x · Cited by 922 · see citing works

The Biological Effects of Childhood Trauma

De Bellis, M. D., & Zisk, A. (2014) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2014.01.002 · Cited by 892 · see citing works

Biology and the Future of Psychoanalysis: A New Intellectual Framework for Psychiatry Revisited

Kandel, E. R. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.4.505 · Cited by 896 · see citing works

Neuroendocrinology of coping styles: Towards understanding the biology of individual variation

Koolhaas, J. M., de Boer, S. F., Coppens, C. M., & Buwalda, B. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.04.001 · Cited by 883 · see citing works

From normal fear to pathological anxiety.

Rosen, J. B., & Schulkin, J. A. (1998) · Psychological Review · doi:10.1037/0033-295x.105.2.325 · Cited by 881 · see citing works

Effects of the social environment and stress on glucocorticoid receptor gene methylation: A systematic review

Turecki, G., & Meaney, M. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.022 · Cited by 796 · see citing works

The biology of fear- and anxiety-related behaviors

Steimer, T. J. (2002) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2002.4.3/tsteimer · Cited by 796 · see citing works

Altered Pituitary-Adrenal Axis Responses to Provocative Challenge Tests in Adult Survivors of Childhood Abuse

Heim, C., Newport, D. J., Bonsall, R., Miller, A. H., & Nemeroff, C. B. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.4.575 · Cited by 746 · see citing works

Traumatic stress: effects on the brain

Bremner, J. D. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/jbremner · Cited by 738 · see citing works

Long-term behavioral and neuroendocrine adaptations to adverse early experience

Ladd, C. O., Huot, R. L., Thrivikraman, K. V., Nemeroff, C. B., Meaney, M. J., & Plotsky, P. M. (2000) · Progress in brain research · doi:10.1016/s0079-6123(08)62132-9 · Cited by 717 · see citing works

The brain and the stress axis: the neural correlates of cortisol regulation in response to stress

Dedovic, K., Duchesne, A., Andrews, J., Engert, V., & Pruessner, J. C. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.074 · Cited by 699 · see citing works

Maternal care and the development of stress responses

Francis, D. D., & Meaney, M. J. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80016-6 · Cited by 677 · see citing works

Chronic stress, cognitive functioning and mental health

Marin, M.-F., Lord, C., Andrews, J., Juster, R.-P., Sindi, S., Arsenault-Lapierre, G., Fiocco, A. J., & Lupien, S. J. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.02.016 · Cited by 654 · see citing works

Enhancing versus suppressive effects of stress hormones on skin immune function

Dhabhar, F. S., & McEwen, B. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.3.1059 · Cited by 672 · see citing works

Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity

Francis, D. D., Diorio, J., Plotsky, P. M., & Meaney, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-18-07840.2002 · Cited by 663 · see citing works

PSYCHONEUROENDOCRINOLOGY OF DEPRESSION

Plotsky, P. M., Owens, M. J., & Nemeroff, C. B. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70006-x · Cited by 672 · see citing works

Research and treatment approaches to depression

Wong, M.-L., & Licinio, J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072566 · Cited by 656 · see citing works

Do early‐life events permanently alter behavioral and hormonal responses to stressors?

Anisman, H., Zaharia, M. D., Meaney, M. J., & Merali, Z. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00025-2 · Cited by 654 · see citing works

Alterations induced by gestational stress in brain morphology and behaviour of the offspring

Weinstock, M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00018-1 · Cited by 791 · see citing works

Prenatal stress, glucocorticoids and the programming of adult disease

Cottrell, E. C. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.019.2009 · Cited by 640 · see citing works

Early life experience alters response of adult neurogenesis to stress

Mirescu, C., Peters, J. D., & Gould, E. (2004) · Nature Neuroscience · doi:10.1038/nn1290 · Cited by 625 · see citing works

The NPY system in stress, anxiety and depression

Heilig, M. A. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.05.002 · Cited by 617 · see citing works

Can Adverse Neonatal Experiences Alter Brain Development and Subsequent Behavior?

Anand, K. J. S., & Scalzo, F. M. (2000) · Neonatology · doi:10.1159/000014197 · Cited by 615 · see citing works

Prenatal stress, glucocorticoids and the programming of the brain

Welberg, L. A. M., & Seckl, J. R. (2001) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2001.00601.x · Cited by 928 · see citing works

The Effects of Early Rearing Environment on the Development of GABAA and Central Benzodiazepine Receptor Levels and Novelty-Induced Fearfulness in the Rat

Caldji, C. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00110-4 · Cited by 606 · see citing works

Stress and anxiety: Structural plasticity and epigenetic regulation as a consequence of stress

McEwen, B. S., Eiland, L., Hunter, R. G., & Miller, M. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.014 · Cited by 596 · see citing works

Stress-induced redistribution of immune cells–from barracks to boulevards to battlefields: a tale of three hormones–Curt Richter Award winner

Dhabhar, F. S., Malarkey, W. B., Neri, E., & McEwen, B. S. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.008 · Cited by 589 · see citing works

Local Brain Functional Activity Following Early Deprivation: A Study of Postinstitutionalized Romanian Orphans

Chugani, H. T., Behen, M. E., Muzik, O., Juhász, C., Nagy, F. T., & Chugani, D. C. (2001) · NeuroImage · doi:10.1006/nimg.2001.0917 · Cited by 577 · see citing works

Developmental determinants of sensitivity and resistance to stress

Levine, S. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.03.013 · Cited by 574 · see citing works

Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment

Carpenter, L. L., Carvalho, J. P., Tyrka, A. R., Wier, L. M., Mello, A. F., Mello, M. F., Anderson, G. M., Wilkinson, C. W., & Price, L. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.002 · Cited by 564 · see citing works

Modulation of the Hypothalamic-Pituitary-Adrenal Axis by Early Life Stress Exposure

van Bodegom, M., Homberg, J. R., & Henckens, M. J. A. G. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00087 · Cited by 562 · see citing works

Microbiota and host determinants of behavioural phenotype in maternally separated mice

De Palma, G., Blennerhassett, P., Lu, J., Deng, Y., Park, A. J., Green, W., Denou, E., Silva, M. A., Santacruz, A., Sanz, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms8735 · Cited by 517 · see citing works

A Novel Mouse Model for Acute and Long-Lasting Consequences of Early Life Stress

Rice, C. J., Sandman, C. A., Lenjavi, M. R., & Baram, T. Z. (2008) · Endocrinology · doi:10.1210/en.2008-0633 · Cited by 521 · see citing works

The neurobiology of childhood trauma and abuse

van der Kolk, B. A. (2003) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/s1056-4993(03)00003-8 · Cited by 544 · see citing works

Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats

Aisa, B., Tordera, R. M., Lasheras, B., Rı́o, J. D., & Ramírez, M. J. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.12.013 · Cited by 534 · see citing works

Does Prenatal Stress Impair Coping and Regulation of Hypothalamic-Pituitary-Adrenal Axis?

Weinstock, M. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00014-0 · Cited by 539 · see citing works

Child abuse and neglect and the brain–a review

Glaser, D. (2000) · Journal of Child Psychology and Psychiatry · doi:10.1017/s0021963099004990 · Cited by 827 · see citing works

Long term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring

Plotsky, P. M., Thrivikraman, K. V., Nemeroff, C. B., Caldji, C., Sharma, S., & Meaney, M. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300769 · Cited by 522 · see citing works

Childhood sexual abuse as a risk factor for depression in women: Psychosocial and neurobiological correlates

Weiss, E. L., Longhurst, J. G., & Mazure, C. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.816 · Cited by 517 · see citing works

Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation

Ladd, C. O., Owens, M. J., & Nemeroff, C. B. (1996) · Endocrinology · doi:10.1210/endo.137.4.8625891 · Cited by 511 · see citing works

Importance of studying the contributions of early adverse experience to neurobiological findings in depression

Heim, C., Plotsky, P. M., & Nemeroff, C. B. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300397 · Cited by 514 · see citing works

Effects of early adverse experiences on brain structure and function: clinical implications

Kaufman, J., Plotsky, P. M., Nemeroff, C. B., & Charney, D. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00998-7 · Cited by 508 · see citing works

Epigenetic mechanisms mediating the long-term effects of maternal care on development

Champagne, F. A., & Curley, J. P. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.10.009 · Cited by 504 · see citing works

Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment

Huot, R. L., Thrivikraman, K. V., Meaney, M. J., & Plotsky, P. M. (2001) · Psychopharmacology · doi:10.1007/s002130100701 · Cited by 507 · see citing works

Chronic pain, chronic stress and depression: Coincidence or consequence?

Blackburn‐Munro, G., & Blackburn‐Munro, R. E. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.0007-1331.2001.00727.x · Cited by 493 · see citing works

Neural Mechanisms of Stress Resilience and Vulnerability

Franklin, T. B., Saab, B. J., & Mansuy, I. M. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.016 · Cited by 500 · see citing works

Sexual Abuse and Lifetime Diagnosis of Somatic Disorders: A Systematic Review and Meta-analysis

Paras, M. L., Murad, M. H., Chen, L. P., Goranson, E. N., Sattler, A. L., Colbenson, K. M., Elamin, M. B., Seime, R. J., Prokop, L. J., & Zirakzadeh, A. (2009) · JAMA · doi:10.1001/jama.2009.1091 · Cited by 490 · see citing works

Risk of recurrence of bipolar disorder in pregnant and nonpregnant women after discontinuing lithium maintenance

Viguera, A. C., Nonacs, R., Cohen, L. S., Tondo, L., Murray, A., & Baldessarini, R. J. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.2.179 · Cited by 488 · see citing works

Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long–Evans rats

Kalinichev, M., Easterling, K. W., Plotsky, P. M., & Holtzman, S. G. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00781-5 · Cited by 484 · see citing works

Childhood experience and the expression of genetic potential: what childhood neglect tells us about nature and nurture

Perry, B. D. (2002) · Brain and Mind · doi:10.1023/a:1016557824657 · Cited by 480 · see citing works

Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys

Coe, C. L., Kramer, M., Czéh, B., Gould, E., Reeves, A. J., Kirschbaum, C., & Fuchs, E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00698-x · Cited by 477 · see citing works

Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation

Gareau, M. G., Jury, J., MacQueen, G., Sherman, P. M., & Perdue, M. H. (2007) · Gut · doi:10.1136/gut.2006.117176 · Cited by 472 · see citing works

Prenatal Stress and Risk for Psychopathology: Specific Effects or Induction of General Susceptibility?

Huizink, A. C., Mulder, E. J. H., & Buitelaar, J. K. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.1.115 · Cited by 473 · see citing works

Developmental neurobiology of childhood stress and trauma

Teicher, M. H., Andersen, S. L., Polcari, A., Anderson, C. M., & Navalta, C. P. (2002) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(01)00003-x · Cited by 607 · see citing works

Long-term neurobehavioural impact of the postnatal environment in rats: manipulations, effects and mediating mechanisms

Pryce, C. R., & Feldon, J. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00009-5 · Cited by 460 · see citing works

Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat

Coutinho, S. V., Plotsky, P. M., Sablad, M., Miller, J. C., Zhou, H., Bayati, A. I., McRoberts, J. A., & Mayer, E. A. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00240.2001 · Cited by 456 · see citing works

Chapter 21 Like mother, like daughter: evidence for non-genomic transmission of parental behavior and stress responsivity

Champagne, F., & Meaney, M. J. (2001) · Progress in Brain Research · doi:10.1016/s0079-6123(01)33022-4 · Cited by 455 · see citing works

Influence of Neonatal Rearing Conditions on Stress‐Induced Adrenocorticotropin Responses and Norepinepherine Release in the Hypothalamic Paraventricular Nucleus

Liu, Caldji, Sharma, Plotsky, & Meaney (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00422.x · Cited by 451 · see citing works

Long-term Biobehavioral Effects of Maternal Separation in the Rat: Consistent or Confusing?

Lehmann, J., & Feldon, J. (2000) · Reviews in the Neurosciences · doi:10.1515/revneuro.2000.11.4.383 · Cited by 447 · see citing works

The stress cascade and schizophrenia: Etiology and onset

Corcoran, C., Walker, E., Huot, R., Mittal, V., Tessner, K., Kestler, L., & Malaspina, D. (2003) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007038 · Cited by 439 · see citing works

Periodic Maternal Deprivation Induces Gender-Dependent Alterations in Behavioral and Neuroendocrine Responses to Emotional Stress in Adult Rats

Wigger, A., & Neumann, I. D. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00300-x · Cited by 443 · see citing works

The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis

Heim, C., Newport, D. J., Wagner, D., Wilcox, M. M., Miller, A. H., & Nemeroff, C. B. (2002) · Depression and Anxiety · doi:10.1002/da.10015 · Cited by 433 · see citing works

Long-Term Behavioral Effects of Repetitive Pain in Neonatal Rat Pups

Anand, K. J. S., Coskun, V, Thrivikraman, K. V., Nemeroff, C. B., & Plotsky, P. M. (1999) · Physiology &amp; Behavior · doi:10.1016/s0031-9384(98)00338-2 · Cited by 432 · see citing works

Clinical Importance of Pain and Stress in Preterm Neonates

Anand, K. J. S. (1997) · Neonatology · doi:10.1159/000013953 · Cited by 430 · see citing works

Causal effects of the early caregiving environment on development of stress response systems in children

McLaughlin, K. A., Sheridan, M. A., Tibu, F., Fox, N. A., Zeanah, C. H., & Nelson, C. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423363112 · Cited by 426 · see citing works

Maternal separation as a model of brain-gut axis dysfunction

O’Mahony, S. M., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2010-9 · Cited by 415 · see citing works

Epigenetics across the human lifespan

Kanherkar, R. R., Bhatia-Dey, N., & Csoka, A. B. (2014) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2014.00049 · Cited by 407 · see citing works

Long-term effects of early-life environmental manipulations in rodents and primates: Potential animal models in depression research

Pryce, C. R., Rüedi‐Bettschen, D., Dettling, A. C., Weston, A. A., Russig, H. D., Ferger, B., & Feldon, J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.011 · Cited by 414 · see citing works

Dysfunctional nurturing behavior in rat dams with limited access to nesting material: A clinically relevant model for early-life stress

Ivy, A. S., Brunson, K. L., Sandman, C., & Baram, T. Z. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.019 · Cited by 407 · see citing works

The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders

Heim, C., & Nemeroff, C. B. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00224-3 · Cited by 502 · see citing works

Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2

Peña, C. J., Kronman, H. G., Walker, D. M., Cates, H. M., Bagot, R. C., Purushothaman, I., Issler, O., Loh, Y.-H. E., Leong, T., Kiraly, D. D., et al. (2017) · Science · doi:10.1126/science.aan4491 · Cited by 394 · see citing works

Neonatal procedural pain exposure predicts lower cortisol and behavioral reactivity in preterm infants in the NICU

GRUNAU, R. E., Holsti, L., Haley, D. W., Oberlander, T. F., Weinberg, J., Solimano, A. J., Whitfield, M. F., Fitzgerald, C., & Yu, W. K. (2004) · Pain · doi:10.1016/j.pain.2004.10.020 · Cited by 390 · see citing works

The effects of chronic stress on the human brain: From neurotoxicity, to vulnerability, to opportunity

LUPIEN, S. J., Juster, R., Raymond, C., & Marin, M. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.02.001 · Cited by 400 · see citing works

Stress and the Microbiota–Gut–Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome

Moloney, R. D., Johnson, A. C., O’Mahony, S. M., Dinan, T. G., Meerveld, B. G., & Cryan, J. F. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12490 · Cited by 396 · see citing works

Immune and neuroendocrine mechanisms of stress vulnerability and resilience

Ménard, C., Pfau, M. L., Hodes, G. E., & Russo, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.90 · Cited by 374 · see citing works

Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats

Huot, R. L., Plotsky, P. M., Lenox, R. H., & McNamara, R. K. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02985-2 · Cited by 383 · see citing works

Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty

Champagne, F. A., & Meaney, M. J. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.6.1353 · Cited by 381 · see citing works

Long term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring

Plotsky, P. M., Thrivikraman, K. V., Nemeroff, C. B., Caldji, C., Sharma, S., & Meaney, M. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300769 · Cited by 522 · see citing works

Handling in Infancy: Increased Levels of the Hypothalamic Corticotropin Releasing Factor (CRF) Following Exposure to a Novel Situation

ZARROW, M. X., Campbell, P. S., & Denenberg, V. H. (1972) · Experimental Biology and Medicine · doi:10.3181/00379727-141-36776 · Cited by 60 · see citing works

Down-Regulation of Hypothalamic Corticotropin-Releasing Hormone Messenger Ribonucleic Acid (mRNA) Precedes Early-Life Experience-Induced Changes in Hippocampal Glucocorticoid Receptor mRNA

Avishai‐Eliner, S., Eghbal-Ahmadi, M., Tabachnik, E., Brunson, K. L., & Baram, T. Z. (2001) · Endocrinology · doi:10.1210/endo.142.1.7917 · Cited by 144 · see citing works

Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: A putative role for corticotropin-releasing factor

Pihoker, C. (1993) · Psychoneuroendocrinology · doi:10.1016/0306-4530(93)90042-j · Cited by 129 · see citing works

Dynamic Changes in the Hypothalamic Content of Corticotropin Releasing Factor Following Noxious Stimuli: Delayed Response in Early Neonates in Comparison with Biphasic Response in Adult Rats

Hiroshige, T., SATO, T., & ABE, K. (1971) · Endocrinology · doi:10.1210/endo-89-5-1287 · Cited by 28 · see citing works