Male mice ultrasonic vocalizations enhance female sexual approach and hypothalamic kisspeptin neuron activity

Asaba, Akari; Osakada, Takuya; Touhara, Kazushige; Kato, Masahiro; Mogi, Kazutaka; Kikusui, Takefumi

doi:10.1016/j.yhbeh.2017.06.006

Cited by 56Hypothalamic control of reproductive hormonesAnimal Vocal Communication and BehaviorNeuroendocrine regulation and behavior

Male mice ultrasonic vocalizations enhance female sexual approach and hypothalamic kisspeptin neuron activity

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Asaba, Akari, Osakada, Takuya, Touhara, Kazushige, Kato, Masahiro, Mogi, Kazutaka, Kikusui, Takefumi·2017·Hormones and Behavior

DOI 10.1016/j.yhbeh.2017.06.006

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Abstract

Vocal communication in animals is important for ensuring reproductive success. Male mice emit song-like "ultrasonic vocalizations (USVs)" when they encounter female mice, and females show approach to the USVs. However, it is unclear whether USVs of male mice trigger female behavioral and endocrine responses in reproduction. In this study, we first investigated the relationship between the number of deliveries in breeding pairs for 4months and USVs syllables emitted from those paired males during 3min of sexual encounter with unfamiliar female mice. There was a positive correlation between these two indices, which suggests that breeding pairs in which males could emit USVs more frequently had more offspring. Further, we examined the effect of USVs of male mice on female sexual behavior. Female mice showed more approach behavior towards vocalizing males than devocalized males. Finally, to determine whether USVs of male mice could activate the neural system governing reproductive function in female mice, the activation of kisspeptin neurons, key neurons to drive gonadotropin-releasing hormone neurons in the hypothalamus, was examined using dual-label immunocytochemistry with cAMP response element-binding protein phosphorylation (pCREB). In the arcuate nucleus (Arc), the number of kisspeptin neurons expressing pCREB significantly increased after exposure to USVs of male as compared with noise exposure group. In conclusion, our results suggest that USVs of male mice promote fertility in female mice by activating both their approaching behavior and central kisspeptin neurons.

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Upon hearing male ultrasonic vocalizations, female mice show activation of kisspeptin neurons in the arcuate nucleus responsible for driving reproduction, providing a mechanism whereby male auditory cues promote fertility and approach behavior in females.
“Additionally, upon hearing male USVs, female mice show activation of kisspeptin neurons in the arcuate nucleus responsible for driving reproduction, providing a mechanism whereby male auditory cues promote fertility and approach behavior in females [91].”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [91]

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Authors: Asaba, A., Osakada, T., Touhara, K., Kato, M., Mogi, K., & Kikusui, T.
Affiliations: Azabu University (JP)
Japan Science and Technology Agency (JP)
Corresponding author: Kikusui, Takefumi
ORCID: Osakada, Takuya
Touhara, Kazushige
Kato, Masahiro
Mogi, Kazutaka
Kikusui, Takefumi
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 2017-08
Volume: 94
Pages: 53-60
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/j.yhbeh.2017.06.006
OpenAlex: W2725911311
Cited by: 56
References: 48
Citations by year: 2026: 6 · 2025: 6 · 2024: 3 · 2023: 8 · 2022: 7 · 2021: 3 · 2020: 10 · 2019: 3 · 2018: 8 · 2017: 2
FWCI: 7.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 332 d)
Locations: Hormones and Behavior (acceptedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science (13J08901, 15K14881)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Animal Vocal Communication and Behavior
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords: ultrasonic vocalizations, male mice, kisspeptin neurons, hypothalamus, arcuate nucleus, pCREB, gonadotropin-releasing hormone, female fertility, breeding pairs, sexual encounters
MeSH terms: Ultrasonic Waves, Animals, Courtship, Female, Hypothalamus, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred ICR, Neurons, Sexual Behavior, Animal, Vocalization, Animal, Mice, Kisspeptins

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Male mice ultrasonic vocalizations enhance female sexual approach and hypothalamic kisspeptin neuron activity

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