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An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1
Abstract
Leptin is a 16 kDa product of the obesity gene secreted primarily by adipocytes. We recently identified cardiomyocytes as a target for the direct hypertrophic effects of leptin and suggested that leptin may be a biological link between obesity and cardiovascular pathologies. Activation of the renin-angiotensin and endothelin systems is associated with development of cardiovascular diseases and plasma renin levels are elevated in obese individuals. We therefore determined possible interaction between these factors in mediating hypertrophy in cultured neonatal rat ventricular myocytes. Treatment for 24 h with leptin (3.1 nM), angiotensin II (100 nM) or endothelin-1 (ET-1, 10 nM) significantly increased cell area by 37%, 36% and 35%, respectively and significantly increased gene expression of myosin light chain-2 and alpha-skeletal actin as well as leucine incorporation. The hypertrophic effects of all three agents were prevented by leptin and a leptin triple mutant receptor antagonist whereas the AT(1) receptor blocker (Sar1-lle(8))-Ang II or the ET(A) receptor blocker BQ123 was ineffective against leptin-induced hypertrophy. Both angiotensin II and ET-1 significantly increased leptin levels in the culture medium by fivefold. Moreover, both angiotensin II and ET-1 increased the gene expression of the short form (OBRa) by 180% and long form (OBRb) of leptin receptors by 200%, and this increase was abolished by both leptin receptor and leptin antibodies and leptin triple mutant. Although both angiotensin II and ET-1 increased phosphorylation of MAPK (p38, ERK1/2 and JNK) and NF-kappaB, the ability of leptin blockade to attenuate the hypertrophic responses was generally dissociated from these effects suggesting an alternate, yet to be identified cellular pathway mediating this role of leptin. Our studies therefore suggest a novel autocrine function for leptin in mediating the hypertrophic effects of both angiotensin II and ET-1 in cardiac myocytes.
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“Importantly, there is also a growing appreciation for the potential importance of autocrine and paracrine effects mediated by adipokines derived from myocardium itself or the larger pericardial fat mass in obese subjects (153, 220, 281, 285, 293).”
From Cardiac remodeling in obesity (2008) · cites this paper as [293]
In the citing paper
“Several reports have suggested that leptin directly induced hypertrophy in both human and rodent cardiomyocytes (217, 292, 293, 379).”
From Cardiac remodeling in obesity (2008) · cites this paper as [293]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Abnormal splicing of the leptin receptor in diabetic mice
Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327
The stomach is a source of leptin
Bado, A., Levasseur, S., Attoub, S., Kermorgant, S., Laigneau, J., Bortoluzzi, M.-N., Moizo, L., Lehy, T., Guerre-Millo, M., MARCHAND‐BRUSTEL, Y. L., et al. (1998) · Nature · doi:10.1038/29547 · Cited by 1,242
Leptin: a review of its peripheral actions and interactions
Margetic, S., Gazzola, C., Pegg, G. G., & Hill, R. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802142 · Cited by 1,022
Wallace, A. M., McMahon, A. D., Packard, C. J., Kelly, A., Shepherd, J., Gaw, A., & Sattar, N. A. (2001) · Circulation · doi:10.1161/hc5001.101061 · Cited by 821
Barouch, L. A., Berkowitz, D. E., Harrison, R. W., O’Donnell, C. P., & Hare, J. M. (2003) · Circulation · doi:10.1161/01.cir.0000083716.82622.fd · Cited by 341
The Obesity-Associated Peptide Leptin Induces Hypertrophy in Neonatal Rat Ventricular Myocytes
Rajapurohitam, V., Gan, X. T., Kirshenbaum, L. A., & Karmazyn, M. (2003) · Circulation Research · doi:10.1161/01.res.0000089255.37804.72 · Cited by 248
Self-citationLappas, M., Permezel, M., & Rice, G. E. (2005) · Endocrinology · doi:10.1210/en.2005-0406 · Cited by 241
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Li, H., Li, M., Liu, P., Wang, Y., Zhang, H., Li, H., Yang, S.-F., Song, Y., Yin, Y., Gao, L., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07008 · Cited by 66
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Duda, M. K., O’Shea, K. M., Lei, B., Barrows, B. R., Azimzadeh, A. M., McElfresh, T. A., Hoit, B. D., Kop, W. J., & Stanley, W. C. (2008) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2007.11.003 · Cited by 54
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Leifheit‐Nestler, M., Wagner, N., Gogiraju, R., Didié, M., Konstantinides, S., Hasenfuss, G. P., & Schäfer, K. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-170 · Cited by 48
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Rodrı́guez, A., Becerril, S., Valentí, V., Moncada, R., Méndez-Giménez, L., Ramírez, B., Lancha, A., Martín, M., Burrell, M. A., Catalán, V., et al. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0702-4 · Cited by 45
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Abundis, E. M., Rajapurohitam, V., Haist, J. V., Gan, X. T., & Karmazyn, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041612 · Cited by 28
Self-citationLeptin, a mediator of cardiac damage associated with obesity
Martínez‐Martínez, E., Jurado-López, R., Cervantes-Escalera, P., Cachofeiro, V., & Miana, M. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0060 · Cited by 27
Singh, U. P., Singh, N. P., Guan, H., Busbee, P. B., Price, R. L., Taub, D. D., Mishra, M. K., Fayad, R., Nagarkatti, M., & Nagarkatti, P. S. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2013.809071 · Cited by 29
Obesity-induced upregulation of myocardial endothelin-1 expression is mediated by leptin
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Lin, Y., Chen, Y., Huang, J.-H., Lin, Y., Huang, S.-S., Chen, S.-A., & Chen, Y. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-94 · Cited by 27
Hou, N., Luo, M., Liu, S., Zhang, H., Xiao, Q., Sun, P., Zhang, G., Luo, J., & Chen, M. (2010) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2010.05442.x · Cited by 25
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Inhibition of cardiac leptin expression after infarction reduces subsequent dysfunction
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Self-citationCingolani, H. E., Pérez, N. G., Caldiz, C. I., Garciarena, C. D., Giusti, V. C. D., Correa, M. V., Villa‐Abrille, M. C., Yeves, A. M., Ennis, I. L., de Cingolani, G. C., et al. (2009) · Springer eBooks · doi:10.1007/978-90-481-2850-1_13 · Cited by 8
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Xu, M., Ji, H., Dai, D., Tang, X., & Dai, Y. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.6.0009 · Cited by 5
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Self-citationZheng, H., Xie, N., Xu, H., Huang, J., Xie, X., & Luo, M. (2013) · Folia Biologica · doi:10.14712/fb2013059060246 · Cited by 4
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Karmazyn, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803111-7.00003-8 · Cited by 2
Self-citationHurtado-Sierra, D., Colin-Ramírez, E., Lena-Hernández, E. L., Sánchez-Cornelio, C., Trujeque-Ruiz, L., Aguilar-Morales, T. I., García-Dávalos, I., Vallejo, M., & Vázquez-Antona, C. A. (2020) · Archivos de cardiolog�a de M�xico (English ed Internet) · doi:10.24875/acme.m19000051 · Cited by 2
Leptin Signaling in the Cardiovascular System
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Self-citation
Metadata
- Authors
- Rajapurohitam, V., Javadov, S., Purdham, D. M., Kirshenbaum, L. A., & Karmazyn, M.
- Affiliations
- Western University (CA)
- St. Boniface Hospital (CA)
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 41
- Issue
- 2
- Pages
- 265-274
- ISSN
- 0022-2828 (ISSN-L)
- OpenAlex
- W2008347790
- Cited by
- 102
- References
- 43
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 8 · 2012: 7
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular and Cellular Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- leptin, cardiomyocyte hypertrophy, angiotensin II, endothelin-1, autocrine signaling, leptin receptor, obesity, renin-angiotensin system, endothelin system, MAPK signaling, NF-κB, myosin light chain 2, alpha-skeletal actin, ventricular myocytes
- MeSH terms
- Angiotensin II, Animals, Animals, Newborn, Cells, Cultured, Gene Expression Regulation, Cardiomegaly, Heart Ventricles, Obesity, Vasoconstrictor Agents, Rats, Sprague-Dawley, Adipocytes, Endothelin-1, Autocrine Communication, Leptin, MAP Kinase Signaling System, Myocytes, Cardiac, Rats
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