The cardiac pacemaker current

The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity

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Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes

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Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes

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Differentiation of Human Embryonic Stem Cells to Cardiomyocytes: Role of Coculture With Visceral Endoderm-Like Cells

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Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling

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Electromechanical integration of cardiomyocytes derived from human embryonic stem cells

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Pacemaker Mechanisms in Cardiac Tissue

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Shenfu Injection: A Famous Chinese Prescription That Promotes HCN4 Activity in Bone Marrow Mesenchymal Stem Cells

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Molecular Mechanisms of Cardiac Electrical Activity

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Adhesive-Electrocoupling Hydrogels for Tissue Regeneration: Design, Mechanisms, and Perspectives

Zhao, J., Chen, Y. L., Zuo, M., Lu, X., & Xie, C. (2026) · Research · doi:10.34133/research.1296 · Cited by 2

HCN Channels and Cardiac Pacemaking

Bucchi, A., Piantoni, C., Barbuti, A., DiFrancesco, D., & Baruscotti, M. (2018) · Cardiac and vascular biology · doi:10.1007/978-3-319-77812-9_5 · Cited by 2

The “Funny” Pacemaker Current

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Differentiation induction of mouse cardiac stem cells into sinus node-like cells by co-culturing with sinus node.

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A New Mechanism of Supraventricular Tachycardia: Gene Mutation

Gao, J., Luo, R., & Li, X. (2025) · Current Cardiology Reviews · doi:10.2174/011573403x320610250108113731 · Cited by 2

Reduced Macroscopic Models: The Monodomain and Eikonal Models

Franzone, P. C., Pavarino, L. F., & Scacchi, S. (2014) · Modeling, simulation & applications · doi:10.1007/978-3-319-04801-7_4 · Cited by 1

Evaluation of surface roughness of titanium implants on human fibroblast cells

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In Quest of a Sinoatrial Cell Model to Assess the Functional Effects of Mutations in the HCN4 Funny Current Gene

Wilders, R., & Verkerk, A. O. (2016) · Computing in cardiology · doi:10.22489/cinc.2016.242-212 · Cited by 1

OBSOLETE: Cellular Sinoatrial Node and Atrioventricular Node Activity in the Heart

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Design of a Novel Current Controlling Module for Functional Electrical Stimulation (FES) System

Chamal, D. R. P., Fernando, M. I. M., Kulathunga, W. P. M. W., Pathirana, K. D., & Prins, N. W. (2021) · International Conference on Information Technology Research (ICITR) · doi:10.1109/icitr54349.2021.9657272 · Cited by 1

Therapeutic Equipment and Its Enhancement via Computational Techniques

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Functional Characterization of the A414G Loss-of-Function Mutation in HCN4 Associated with Sinus Bradycardia

Verkerk, A. O., & Wilders, R. (2023) · Cardiogenetics · doi:10.3390/cardiogenetics13030012 · Cited by 1

Exploring Vulnerabilities and Attack Vectors Targeting Pacemaker Devices in Healthcare

Chardenet, B., Jamssens, J., Cummins, R., & Mohd, T. K. (2024) · International Journal on Cybernetics & Informatics · doi:10.5121/ijci.2024.130212 · Cited by 1

Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff

Ziyatdinova, N. I., Kuptsova, A. M., Faskhutdinov, L. I., Galieva, A. M., Zefirov, A. L., & Zefirov, Т. L. (2019) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-019-04541-w · Cited by 1

Mechanism of Sinus Bradycardia in Carriers of the a414G Mutation in the HCN4 Gene

Verkerk, A. O., & Wilders, R. (2019) · Computing in cardiology · doi:10.22489/cinc.2019.147 · Cited by 1

Parallel Solvers for the Bidomain System

Franzone, P. C., Pavarino, L. F., & Scacchi, S. (2014) · Modeling, simulation & applications · doi:10.1007/978-3-319-04801-7_8 · Cited by 1

Ivabradine's Pleiotropic Profile: Can It Protect Against Doxorubicin-Induced Heart Failure?

Verrier, R. L. (2018) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000597 · Cited by 1

Inappropriate Tachycardia Syndrome: A Complex Arrhythmia Syndrome Not Limited to the Sino-Atrial NodePreprint

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Automaticité dans le coeur ischémique : analyse de bifurcation d’un modèle mathématique de cellule ventriculaire humaine

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Mathematical Models of Cellular Bioelectrical Activity

Franzone, P. C., Pavarino, L. F., & Scacchi, S. (2014) · Modeling, simulation & applications · doi:10.1007/978-3-319-04801-7_2

Mechanisms regulating PKA phosphorylation of the key cardiac proteins Troponin I and Hsp20

Edwards, H. V. (2012) · Enlighten: Theses (The University of Glasgow)

Bradyarrhythmia Therapies: The Creation of Biological Pacemakers and Restoring Atrioventricular Node Function

Robinson, R. B. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-021-8_18

Role of T-Type Ca2+ Channels in the Development of Arrhythmias and Ischemia–Reperfusion Injury

Schaffer, S. W. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1413-1_6

Cellular cardiac electrophysiological effects of HCN channel blockers

Koncz, I. (2014) · doi:10.14232/phd.2297

Simulation Studies of Cardiac Bioelectrical Activity

Franzone, P. C., Pavarino, L. F., & Scacchi, S. (2014) · Modeling, simulation & applications · doi:10.1007/978-3-319-04801-7_9

A kinetic model for the HCN2 ion channel

Kim, J. G. (2013) · cIRcle (University of British Columbia) · doi:10.14288/1.0073987

UNIVERSITÁ DEGLI STUDI DI MILANO FACOLTÁ DI MEDICINA E CHIRURGIA

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Basic Cardiac Anatomy and Electrocardiology

Franzone, P. C., Pavarino, L. F., & Scacchi, S. (2014) · Modeling, simulation & applications · doi:10.1007/978-3-319-04801-7_1

Stem Cell–Derived Sinoatrial-Like Cardiomyocytes as a Novel Pharmacological Tool

Barbuti, A., & Robinson, R. B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-44733-1.00025-0

Mechanism of Sinus Bradycardia in Carriers of the 1795insD Mutation in the SCN5A Gene

Wilders, R. (2017) · Computing in cardiology · doi:10.22489/cinc.2017.021-424

Bradycardic Effects of Mutations in the HCN4 Gene at Different Levels of Autonomic Tone in Humans

Fabbri, A., Verkerk, A. O., Severi, S., & Wilders, R. (2017) · Computing in cardiology · doi:10.22489/cinc.2017.017-008

Numerical Methods for the Bidomain and Reduced Models

Franzone, P. C., Pavarino, L. F., & Scacchi, S. (2014) · Modeling, simulation & applications · doi:10.1007/978-3-319-04801-7_7

Mechanism of Sinus Node Dysfunction in Carriers of the E161K Mutation in the SCN5A Gene

Wilders, R. (2018) · Computing in cardiology · doi:10.22489/cinc.2018.267

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Mathematical Models of Cardiac Cells Arrangements: The Bidomain Model

Franzone, P. C., Pavarino, L. F., & Scacchi, S. (2014) · Modeling, simulation & applications · doi:10.1007/978-3-319-04801-7_3

Supraventricular Dysrhythmias in the Critically Ill: Diagnostic and Prognostic Implications

Brotfain, E., Klein, M., & Marshall, J. C. (2014) · Springer eBooks · doi:10.1007/978-3-319-03746-2_32

Anisotropic Cardiac Sources

Franzone, P. C., Pavarino, L. F., & Scacchi, S. (2014) · Modeling, simulation & applications · doi:10.1007/978-3-319-04801-7_5

Functional Role of the HCN4 Encoded ‘Funny Current’ in Human Sinus Node Pacemaker Cells

Verkerk, A. O., & Wilders, R. (2021) · Computing in cardiology · doi:10.23919/cinc53138.2021.9662853

Neuroprosthetics

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Ions channels and currents

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Tunicamycin Attenuates Cardiac Automaticity by Reducing HCN Current

Zhang, J. (2022) · International Journal of Frontiers in Medicine · doi:10.25236/ijfm.2022.040307

The “Funny” Pacemaker Current

Barbuti, A., Baruscotti, M., & Bucchi, A. (2023) · Springer eBooks · doi:10.1007/978-3-031-33588-4_4

Cellular Sinoatrial Node and Atrioventricular Node Activity in the Heart

Jansen, H. J., Quinn, T. A., & Rose, R. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15734-9.00032-7

Myocardial and Valvular Diseases

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IGF-1 promotes cell surface expression of HCN4 pacemaker channels contributing to tachycardia

Erlenhardt, N., Wohlfarth, F., Moussavi‐Torshizi, S., Koch, A., Strasdeit, T., Scherschel, K., Amin, E., Anstötz, M., Meyer, C., & Klöcker, N. (2025) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2025.10.015 · Cited by 1

Sinoatrial Node Dynamics: Clinical Relevance and microRNA-Based Modulation of Pacemaker Activity

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Ιmplicatiοn des prοtéines EΡAC dans la régulatiοn de l'activité électrique des cardiοmyοcytes

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BindingDB Entry 50001859: Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents.

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HCN Channels and Cardiac Pacemaking

Bucchi, A., Piantoni, C., Barbuti, A., DiFrancesco, D., & Baruscotti, M. (2018) · Cardiac and vascular biology · doi:10.1007/978-3-319-77812-9_5 · Cited by 2

HCN channels in the heart: lessons from mouse mutants

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The “Funny” Pacemaker Current

Barbuti, A., Baruscotti, M., & Bucchi, A. (2023) · Springer eBooks · doi:10.1007/978-3-031-33588-4_4

Serious workings of the funny current

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Hyperpolarization-activated Cyclic Nucleotide-gated Channel 1 Is a Molecular Determinant of the Cardiac Pacemaker Current I f

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