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A translational study of urine miRNAs in acute myocardial infarction
Open accessAbstract
The currently used biomarkers for acute myocardial infarction (AMI) are blood creatinine phosphokinase-muscle band (CPK-MB), troponin-T (TnT), and troponin I (TnI). However, no good biomarkers are identified in urine after AMI, because these blood protein biomarkers are difficult to be filtered into urine. In this study, the role of urine microRNAs in the diagnosis of AMI and the mechanism involved were determined. We found that urine miR-1 was quickly increased in rats after AMI with peak at 24 h after AMI, in which an over 50-fold increase was demonstrated. At 7 days after AMI, the urine miR-1 level was returned to the basal level. No miR-208 was found in normal urine. In urine from rats with AMI, miR-208 was easily detected. To determine the mechanism involved, we determined the levels of heart-released miR-1 in the liver, spleen and kidney after AMI in rats and found that the kidney was an important metabolic organ. To determine the renal elimination of blood miRNAs, we isolated serum exosomes from rats after AMI and injected these exosomes into the circulating blood of normal rats. We found that the urine miR-1 was significantly increased in exosome-injected animals. Moreover, PKH67-labeled exosomes injected into circulating blood could enter into the kidney tissues and cells, as well as urine. Furthermore, the levels of urine miR-1 were significantly increased in patients with AMI. The results suggest that urine miRNAs such as miR-1 could be novel urine biomarkers for AMI.
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Dong, S., Cheng, Y., Yang, J., Li, J., Liu, X., Wang, X., Wang, D., Krall, T. J., Delphin, E. S., & Zhang, C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.027896 · Cited by 454
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Cited by
Erdbrügger, U., Blijdorp, C. J., Bijnsdorp, I. V., Borràs, F. E., Burger, D., Bussolati, B., Byrd, J. B., Clayton, A., Dear, J. W., Falcón‐Pérez, J. M., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12093 · Cited by 404
Increased Circulating Exosomal miRNA-223 Is Associated with Acute Ischemic Stroke
Chen, Y., Song, Y., Huang, J., Qu, M., Zhang, Y., Geng, J., Zhang, Z., Liu, J., & Yang, G.-Y. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00057 · Cited by 207
Osaki, M., Kosaka, N., Okada, F., & Ochiya, T. (2014) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-013-0065-0 · Cited by 13
Extracellular Vesicles and Their Interplay with Biological Membranes
Yeo Xian Ping, J., Raj Neupane, Y., & Pastorin, G. (2022) · Physiology · doi:10.5772/intechopen.101297 · Cited by 9
Metadata
- Authors
- Cheng, Y., Wang, X., Yang, J., Duan, X., Yao, Y., Shi, X., Chen, Z., Fan, Z., Liu, X., Qin, S., Tang, X., & Zhang, C.
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 53
- Issue
- 5
- Pages
- 668-676
- ISSN
- 0022-2828 (ISSN-L)
- OpenAlex
- W1983973523
- Cited by
- 169
- References
- 1
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Cheng, Y., Wang, X., Yang, J., Duan, X., Yao, Y., Shi, X., Chen, Z., Fan, Z., Liu, X., Qin, S., Tang, X., & Zhang, C. (2012). A translational study of urine miRNAs in acute myocardial infarction. Journal of Molecular and Cellular Cardiology. https://doi.org/10.1016/j.yjmcc.2012.08.010
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