The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Circulating MicroRNAs in Drug Safety Assessment for Hepatic and Cardiovascular Toxicity: The Latest Biomarker Frontier?
Abstract
Drug-induced liver and cardiovascular injuries are important aspects of safety evaluations of numerous drugs in development. Therefore, reliable and predictive biomarkers to allow detection of early signs of drug-induced liver and cardiovascular injuries are required in clinical and preclinical pharmaceutical evaluation. MicroRNAs (miRNAs) are reported to be present in body fluids (blood, urine, etc.), and these 'circulating miRNAs' have been proposed as toxicological biomarkers of drug-induced tissue injury in preclinical and clinical practice. To be used as biomarkers of drug toxicity, such miRNAs need to show rapid and injured-tissue-specific upregulation in body fluids after injury, be more sensitive than existing protein markers such as alanine aminotransferase (ALT) and troponins, and be able to identify the toxicants responsible, if possible. In this article, we focus on the current knowledge of circulating miRNAs, which have potential for use in assessment of drug-induced liver and cardiovascular injuries. In addition, we discuss an important question regarding normalization of the expression levels of certain circulating miRNAs in body fluids.
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“Therefore, circulating miRNAs could be utilized as novel liquid biopsy biomarkers [14,15,16,17,18,19,20].”
From Bioinformatic Interrogation of 5p-arm and 3p-arm Specific miRNA Expression Using TCGA Datasets (2015) · cites this paper as [19]
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Cites
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Research works printed but not linked: 1
- Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 2008;105:10513–8. · DOI · Paper page
Cited by
Bioinformatic Interrogation of 5p-arm and 3p-arm Specific miRNA Expression Using TCGA Datasets
Kuo, W.-T., Su, M.-W., Lee, Y., Chen, C.-H., Wu, C.-W., Fang, W.-L., Huang, K.-H., & Lin, W.-C. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4091798 · Cited by 30
Metadata
- Authors
- Osaki, M., Kosaka, N., Okada, F., & Ochiya, T.
- Venue
- Molecular Diagnosis & Therapy
- Published
- 2013-11-06
- Volume
- 18
- Issue
- 2
- Pages
- 121-126
- ISSN
- 1177-1062
- 1179-2000
- Cited by
- 13
- References
- 68
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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- Osaki, M., Kosaka, N., Okada, F., & Ochiya, T. (2014). Circulating MicroRNAs in Drug Safety Assessment for Hepatic and Cardiovascular Toxicity: The Latest Biomarker Frontier? Molecular Diagnosis & Therapy. https://doi.org/10.1007/s40291-013-0065-0
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