The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Monoamine oxidases as sources of oxidants in the heart
Open accessAbstract
Oxidative stress can be generated at several sites within the mitochondria. Among these, monoamine oxidases (MAO) have been described as a prominent source. MAO are mitochondrial flavoenzymes responsible for the oxidative deamination of catecholamines, serotonin and biogenic amines, and during this process they generate H2O2 and aldehyde intermediates. The role of MAO in cardiovascular pathophysiology has only recently gathered some attention since it has been demonstrated that both H2O2 and aldehydes may target mitochondrial function and consequently affect function and viability of the myocardium. In the present review, we will discuss the role of MAO in catecholamine and serotonin clearance and cycling in relation to cardiac structure and function. The relevant contribution of each MAO isoform (MAO-A or -B) will be discussed in relation to mitochondrial dysfunction and myocardial injury. Finally, we will examine both beneficial effects of their pharmacological or genetic inhibition along with potential adverse effects observed at baseline in MAO knockout mice, as well as the deleterious effects following their over-expression specifically at cardiomyocyte level.
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Cites
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Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives
Hajam, Y. A., Rani, R., Ganie, S. Y., Sheikh, T. A., Javaid, D., Qadri, S. S., Pramodh, S., Alsulimani, A., Alkhanani, M. F., Harakeh, S., et al. (2022) · Cells · doi:10.3390/cells11030552 · Cited by 915
Kalogeris, T., Baines, C. P., Krenz, M., & Korthuis, R. J. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c160006 · Cited by 718
Kalogeris, T., Bao, Y., & Korthuis, R. J. (2014) · Redox Biology · doi:10.1016/j.redox.2014.05.006 · Cited by 716
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Metadata
- Authors
- Kaludercic, N., Mialet-Perez, J., Paolocci, N., Parini, A., & Di Lisa, F.
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 73
- Pages
- 34-42
- ISSN
- 0022-2828 (ISSN-L)
- OpenAlex
- W2046592449
- Cited by
- 253
- References
- 17
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Kaludercic, N., Mialet-Perez, J., Paolocci, N., Parini, A., & Di Lisa, F. (2014). Monoamine oxidases as sources of oxidants in the heart. Journal of Molecular and Cellular Cardiology. https://doi.org/10.1016/j.yjmcc.2013.12.032
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