The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection
Open accessAbstract
The mitochondrial permeability transition (PT) - an abrupt increase permeability of the inner membrane to solutes - is a causative event in ischemia-reperfusion injury of the heart, and the focus of intense research in cardioprotection. The PT is due to opening of the PT pore (PTP), a high conductance channel that is critically regulated by a variety of pathophysiological effectors. Very recent work indicates that the PTP forms from the F-ATP synthase, which would switch from an energy-conserving to an energy-dissipating device. This review provides an update on the current debate on how this transition is achieved, and on the PTP as a target for therapeutic intervention. This article is part of a Special Issue entitled "Mitochondria: from basic mitochondrial biology to cardiovascular disease".
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Citations
Cites
Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
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“not an essential pore component [67–70].”
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“not an essential pore component [67–70].”
BackgroundDephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria
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Self-citationThe ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
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“not an essential pore component [67–70].”
BackgroundSelf-citationp53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis
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Self-citation
Cited by
13 reasons why the brain is susceptible to oxidative stress
Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215
ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection
Cadenas, S. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.024 · Cited by 820
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Mitochondria regulation in ferroptosis
Wang, H., Liu, C., Zhao, Y., & Gao, G. (2020) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2019.151058 · Cited by 650
Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death
Battaglia, A. M., Chirillo, R., Aversa, I., Sacco, A., Costanzo, F., & Biamonte, F. (2020) · Cells · doi:10.3390/cells9061505 · Cited by 561
Metadata
- Authors
- Bernardi, P., & Di Lisa, F.
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 78
- Pages
- 100-106
- ISSN
- 0022-2828 (ISSN-L)
- OpenAlex
- W2008235034
- Cited by
- 499
- References
- 15
- FWCI
- 26.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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