The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Mitochondria regulation in ferroptosis
Abstract
Ferroptosis is recognized as a new form of regulated cell death which is initiated by severe lipid peroxidation relying on reactive oxygen species (ROS) generation and iron overload. This iron-dependent cell death manifests evident morphological, biochemical and genetic differences from other forms of regulated cell death, such as apoptosis, autophagy, necrosis and pyroptosis. Ferroptosis was primarily characterized by condensed mitochondrial membrane densities and smaller volume than normal mitochondria, as well as the diminished or vanished of mitochondria crista and outer membrane ruptured. Mitochondria take the center role in iron metabolism, as well as substance and energy metabolism as it's the major organelle in iron utilization, catabolic and anabolic pathways. Interference of key regulators of mitochondrial lipid metabolism (e.g., ASCF2 and CS), iron homeostasis (e.g., ferritin, mitoferrin1/2 and NEET proteins), glutamine metabolism and other signaling pathways make a difference to ferroptotic sensitivity. Targeted induction of ferroptosis was also considered as a potential therapeutic strategy to some oxidative stress diseases, including neurodegenerative disorders, ischemia-reperfusion injury, traumatic spinal cord injury. However, the pertinence between mitochondria and ferroptosis is still in dispute. Here we systematic elucidate the morphological characteristics and metabolic regulation of mitochondria in the regulation of ferroptosis.
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Cites
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Cited by
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Shin, S., Bae, G.-H., Park, J. D., Koh, E.-Y., Ko, S., Han, J., Park, C. G., Kim, D.-H., Na, K., & Park, W. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124002 · Cited by 8
Metadata
- Authors
- Wang, H., Liu, C., Zhao, Y., & Gao, G.
- Venue
- European Journal of Cell Biology
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 99
- Issue
- 1
- Pages
- 151058
- ISSN
- 0171-9335 (ISSN-L)
- OpenAlex
- W2989385987
- Cited by
- 650
- References
- 134
- FWCI
- 35.91
- Type
- journal article
- Language
- en
- Open access
- closed
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