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Cited by 78Autophagy in Disease and TherapyMitochondrial Function and PathologyUbiquitin and proteasome pathways

A time to reap, a time to sow: Mitophagy and biogenesis in cardiac pathophysiology

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Andres, Allen M., Stotland, Aleksandr, Queliconi, Bruno B., Gottlieb, Roberta A.·2015·Journal of Molecular and Cellular Cardiology
DOI 10.1016/j.yjmcc.2014.10.003PMC PMC4268279
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Abstract

Balancing mitophagy and mitochondrial biogenesis is essential for maintaining a healthy population of mitochondria and cellular homeostasis. Coordinated interplay between these two forces that govern mitochondrial turnover plays an important role as an adaptive response against various cellular stresses that can compromise cell survival. Failure to maintain the critical balance between mitophagy and mitochondrial biogenesis or homeostatic turnover of mitochondria results in a population of dysfunctional mitochondria that contribute to various disease processes. In this review we outline the mechanics and relationships between mitophagy and mitochondrial biogenesis, and discuss the implications of a disrupted balance between these two forces, with an emphasis on cardiac physiology. This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease".

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  • Less quality control and mitochondrial turnover is possible in APOE4 astrocytes, leading to increased population of dysfunctional mitochondria.

    “Therefore, less quality control and mitochondrial turnover is possible, leading to increased population of dysfunctional mitochondria50.”

    From Altered mitochondrial dynamics and function in APOE4-expressing astrocytes (2020) · cites this paper as [50]

    The Introduction (page unavailable) states that mitochondrial turnover eliminates dysfunctional mitochondria and that impaired quality control leads to their accumulation. The paper does not establish that quality control or turnover is reduced in APOE4 astrocytes; it provides the general mechanism, not that cell-specific finding. (LLM, conf=0.85)

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  1. [1]Bogaerts V Theuns J van Broeckhoven C Genetic findings in Parkinson's disease and translation into treatment: a leading role for mitochondria? Genes, brain, and behavior 2008 7 129 151 PMC2268956 17680806
  2. [2]Bueler H Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease Exp Neurol 2009 218 235 246 19303005
  3. [3]Park J Kim Y Chung J Mitochondrial dysfunction and Parkinson's disease genes: insights from Drosophila Disease models & mechanisms 2009 2 336 340 19553694
  4. [4]Schapira AH Mitochondria in the aetiology and pathogenesis of Parkinson's disease Lancet neurology 2008 7 97 109 18093566
  5. [5]Trancikova A Tsika E Moore DJ Mitochondrial dysfunction in genetic animal models of Parkinson's disease Antioxid Redox Signal 2012 16 896 919 21848447 PMC3292748
  6. [6]Biskup S Moore DJ Detrimental deletions: mitochondria, aging and Parkinson's disease Bioessays 2006 28 963 967 16998822
  7. [7]Kotake Y Ohta S MPP+ analogs acting on mitochondria and inducing neuro-degeneration Curr Med Chem 2003 10 2507 2516 14529466
  8. [8]Duchen MR Szabadkai G Roles of mitochondria in human disease Essays in biochemistry 2010 47 115 137 20533904
  9. [9]Pellegrino MW Nargund AM Haynes CM Signaling the mitochondrial unfolded protein response Biochim Biophys Acta 2013 1833 410 416 22445420 PMC3393825
  10. [10]Mizushima N Levine B Cuervo AM Klionsky DJ Autophagy fights disease through cellular self-digestion Nature 2008 451 1069 1075 18305538 PMC2670399
  11. [11]Wang C Wang X The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicity Biochim Biophys Acta 2014 PMC4277934 25092168
  12. [12]Andres AM Hernandez G Lee P Huang C Ratliff EP Sin J Mitophagy is Required for Acute Cardioprotection by Simvastatin Antioxid Redox Signal 2013 PMC4208607 23901824
  13. [13]Huang C Andres AM Ratliff EP Hernandez G Lee P Gottlieb RA Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1 PLoS One 2011 6 e20975 21687634 PMC3110820
  14. [15]Chen Y Dorn GW 2nd PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria Science 2013 340 471 475 23620051 PMC3774525
  15. [16]Kubli DA Quinsay MN Huang C Lee Y Gustafsson AB Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion Am J Physiol Heart Circ Physiol 2008 295 H2025 H2031 18790835 PMC2614576
  16. [18]Carreira RS Lee Y Ghochani M Gustafsson AB Gottlieb RA Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells Autophagy 2010 6 462 472 20364102 PMC3768271
  17. [21]Narendra D Tanaka A Suen DF Youle RJ Parkin is recruited selectively to impaired mitochondria and promotes their autophagy J Cell Biol 2008 183 795 803 19029340 PMC2592826
  18. [23]Clark IE Dodson MW Jiang C Cao JH Huh JR Seol JH Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin Nature 2006 441 1162 1166 16672981
  19. [24]Park J Lee SB Lee S Kim Y Song S Kim S Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin Nature 2006 441 1157 1161 16672980
  20. [25]Sugiura A McLelland GL Fon EA McBride HM A new pathway for mitochondrial quality control: mitochondrial-derived vesicles EMBO J 2014 PMC4282503 25107473
  21. [28]Smirnova E Griparic L Shurland DL van der Bliek AM Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells Mol Biol Cell 2001 12 2245 2256 11514614 PMC58592
  22. [29]Yoon Y Krueger EW Oswald BJ McNiven MA The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1 Mol Cell Biol 2003 23 5409 5420 12861026 PMC165727
  23. [30]MacVicar TD Lane JD Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation Journal of cell Science 2014 127 2313 2325 24634514 PMC4021475
  24. [31]Kaser M Kambacheld M Kisters-Woike B Langer T Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA protease J Biol Chem 2003 278 46414 46423 12963738
  25. [32]McBride H Soubannier V Mitochondrial function: OMA1 and OPA1, the grandmasters of mitochondrial health Current biology: CB 2010 20 R274 R276 20334834
  26. [34]Jin SM Lazarou M Wang C Kane LA Narendra DP Youle RJ Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL J Cell Biol 2010 191 933 942 21115803 PMC2995166
  27. [35]Zhou C Huang Y Shao Y May J Prou D Perier C The kinase domain of mitochondrial PINK1 faces the cytoplasm Proc Natl Acad Sci U S A 2008 105 12022 12027 18687899 PMC2575334
  28. [37]Lazarou M Jin SM Kane LA Youle RJ Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin Developmental cell 2012 22 320 333 22280891 PMC3288275
  29. [38]Wang X Winter D Ashrafi G Schlehe J Wong YL Selkoe D PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility Cell 2011 147 893 906 22078885 PMC3261796
  30. [39]Narendra D Kane LA Hauser DN Fearnley IM Youle RJ p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both Autophagy 2010 6 1090 1106 20890124 PMC3359490
  31. [40]Gegg ME Cooper JM Chau KY Rojo M Schapira AH Taanman JW Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy Hum Mol Genet 2010 19 4861 4870 20871098 PMC3583518
  32. [41]Glauser L Sonnay S Stafa K Moore DJ Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1 J Neurochem 2011 118 636 645 21615408
  33. [43]Kirkin V Lamark T Sou YS Bjorkoy G Nunn JL Bruun JA A role for NBR1 in autophagosomal degradation of ubiquitinated substrates Mol Cell 2009 33 505 516 19250911
  34. [44]Pankiv S Clausen TH Lamark T Brech A Bruun JA Outzen H p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy J Biol Chem 2007 282 24131 24145 17580304
  35. [45]Orvedahl A Sumpter R Jr Xiao G Ng A Zou Z Tang Y Image-based genome-wide siRNA screen identifies selective autophagy factors Nature 2011 480 113 117 22020285 PMC3229641
  36. [46]Fimia GM Stoykova A Romagnoli A Giunta L Di Bartolomeo S Nardacci R Ambra1 regulates autophagy and development of the nervous system Nature 2007 447 1121 1125 17589504
  37. [47]Strappazzon F Vietri-Rudan M Campello S Nazio F Florenzano F Fimia GM Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy EMBO J 2011 30 1195 1208 21358617 PMC3094111
  38. [49]Chakrama FZ Seguin-Py S Le Grand JN Fraichard A Delage-Mourroux R Despouy G GABARAPL1 (GEC1) associates with autophagic vesicles Autophagy 2010 6 495 505 20404487
  39. [51]Lee Y Lee HY Hanna RA Gustafsson AB Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes Am J Physiol Heart Circ Physiol 2011 301 H1924 H1931 21890690 PMC3213962
  40. [52]Liu L Feng D Chen G Chen M Zheng Q Song P Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells Nat Cell Biol 2012 14 177 185 22267086
  41. [53]Katayama H Kogure T Mizushima N Yoshimori T Miyawaki A A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery Chemistry & biology 2011 18 1042 1052 21867919
  42. [54]Saita S Shirane M Nakayama KI Selective escape of proteins from the mitochondria during mitophagy Nature communications 2013 4 1410 23361001
  43. [55]Kim TY Wang D Kim AK Lau E Lin AJ Liem DA Metabolic Labeling Reveals Proteome Dynamics of Mouse Mitochondria Mol Cell Proteomics 2012 PMC3518123 22915825
  44. [56]Aschenbrenner B Druyan R Albin R Rabinowitz M Haem a, cytochrome c and total protein turnover in mitochondria from rat heart and liver Biochem J 1970 119 157 160 5488910 PMC1179336
  45. [57]Lipsky NG Pedersen P Mitochondrial turnover in animal cells. Half-lives of mitochondria and mitochondrial subfractions of rat liver based on [14C]bicarbonate incorporation J Biol Chem 1981 256 8652 8657 7263675
  46. [58]Kasumov T Dabkowski ER Shekar KC Li L Ribeiro RF Jr Walsh K Assessment of cardiac proteome dynamics with heavy water: slower protein synthesis rates in interfibrillar than subsarcolemmal mitochondria Am J Physiol Heart Circ Physiol 2013 304 H1201 H1214 23457012 PMC3652088
  47. [59]Hernandez G Thornton C Stotland A Lui D Sin J Ramil J MitoTimer: A novel tool for monitoring mitochondrial turnover Autophagy 2013 9 1852 1861 24128932 PMC4028337
  48. [60]Kubli DA Zhang X Lee Y Hanna RA Quinsay MN Nguyen CK Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction J Biol Chem 2013 288 915 926 23152496 PMC3543040
  49. [61]Kubli DA Quinsay MN Gustafsson AB Parkin deficiency results in accumulation of abnormal mitochondria in aging myocytes Communicative & integrative biology 2013 6 e24511 23986804 PMC3737749
  50. [63]Billia F Hauck L Konecny F Rao V Shen J Mak TW PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function Proc Natl Acad Sci U S A 2011 108 9572 9577 21606348 PMC3111326
  51. [64]Nakai A Yamaguchi O Takeda T Higuchi Y Hikoso S Taniike M The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress Nat Med 2007 13 619 624 17450150
  52. [65]Chen Y Liu Y Dorn GW 2nd Mitochondrial fusion is essential for organelle function and cardiac homeostasis Circ Res 2011 109 1327 1331 22052916 PMC3237902
  53. [66]Wu Z Puigserver P Spiegelman BM Transcriptional activation of adipogenesis Curr Opin Cell Biol 1999 11 689 6894 10600710
  54. [67]Puigserver P Wu Z Park CW Graves R Wright M Spiegelman BM A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis Cell 1998 92 829 839 9529258
  55. [68]Xiao X Wang P Chou KC Recent progresses in identifying nuclear receptors and their families Current topics in medicinal chemistry 2013 13 1192 1200 23647541
  56. [69]Virbasius JV Scarpulla RC Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis Proc Natl Acad Sci U S A 1994 91 1309 1313 8108407 PMC43147
  57. [70]Fisher RP Clayton DA A transcription factor required for promoter recognition by human mitochondrial RNA polymerase. Accurate initiation at the heavy- and light-strand promoters dissected and reconstituted in vitro J Biol Chem 1985 260 11330 11338 4030791
  58. [71]Wu Z Puigserver P Andersson U Zhang C Adelmant G Mootha V Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1 Cell 1999 98 115 124 10412986
  59. [73]Meirhaeghe A Crowley V Lenaghan C Lelliott C Green K Stewart A Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo Biochem J 2003 373 155 165 12678921 PMC1223480
  60. [74]Madrazo JA Kelly DP The PPAR trio: regulators of myocardial energy metabolism in health and disease J Mol Cell Cardiol 2008 44 968 975 18462747
  61. [75]Ventura-Clapier R Garnier A Veksler V Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha Cardiovasc Res 2008 79 208 217 18430751
  62. [76]Giguere V Transcriptional control of energy homeostasis by the estrogen-related receptors Endocrine reviews 2008 29 677 696 18664618
  63. [77]Schreiber SN Emter R Hock MB Knutti D Cardenas J Podvinec M The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis Proc Natl Acad Sci U S A 2004 101 6472 6477 15087503 PMC404069
  64. [78]McDermott-Roe C Ye J Ahmed R Sun XM Serafin A Ware J Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function Nature 2011 478 114 118 21979051 PMC3189541
  65. [79]Marton O Koltai E Takeda M Koch LG Britton SL Davies KJ Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats Pflugers Arch 2014 PMC4272336 24943897
  66. [80]Herzig S Long F Jhala US Hedrick S Quinn R Bauer A CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 Nature 2001 413 179 183 11557984
  67. [81]Handschin C Rhee J Lin J Tarr PT Spiegelman BM An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle Proc Natl Acad Sci U S A 2003 100 7111 7116 12764228 PMC165838
  68. [83]Akimoto T Pohnert SC Li P Zhang M Gumbs C Rosenberg PB Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway J Biol Chem 2005 280 19587 19593 15767263
  69. [84]Zhao M New L Kravchenko VV Kato Y Gram H di Padova F Regulation of the MEF2 family of transcription factors by p38 Mol Cell Biol 1999 19 21 30 9858528 PMC83862
  70. [88]Sano M Tokudome S Shimizu N Yoshikawa N Ogawa C Shirakawa K Intramolecular control of protein stability, subnuclear compartmentalization, and coactivator function of peroxisome proliferator-activated receptor gamma coactivator 1alpha J Biol Chem 2007 282 25970 25980 17620342
  71. [89]Li X Monks B Ge Q Birnbaum MJ Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator Nature 2007 447 1012 1016 17554339
  72. [90]Rodgers JT Haas W Gygi SP Puigserver P Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis Cell Metab 2010 11 23 34 20074525 PMC2807620
  73. [92]Lerin C Rodgers JT Kalume DE Kim SH Pandey A Puigserver P GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha Cell Metab 2006 3 429 438 16753578
  74. [93]Hayashida S Arimoto A Kuramoto Y Kozako T Honda S Shimeno H Fasting promotes the expression of SIRT1, an NAD+ -dependent protein deacetylase, via activation of PPARalpha in mice Mol Cell Biochem 2010 339 285 292 20148352
  75. [94]White AT Schenk S NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise American journal of physiology Endocrinology and metabolism 2012 303 E308 E321 22436696 PMC3423123
  76. [95]Houtkooper RH Canto C Wanders RJ Auwerx J The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways Endocrine reviews 2010 31 194 223 20007326 PMC2852209
  77. [96]Gerhart-Hines Z Rodgers JT Bare O Lerin C Kim SH Mostoslavsky R Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha EMBO J 2007 26 1913 1923 17347648 PMC1847661
  78. [97]Canto C Gerhart-Hines Z Feige JN Lagouge M Noriega L Milne JC AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity Nature 2009 458 1056 1060 19262508 PMC3616311
  79. [98]Fernandez-Marcos PJ Auwerx J Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis The American journal of clinical nutrition 2011 93 884S 890S 21289221 PMC3057551
  80. [99]Wright GL Maroulakou IG Eldridge J Liby TL Sridharan V Tsichlis PN VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase FASEB J 2008 22 3264 3275 18524868 PMC2518259
  81. [101]O'Hagan KA Cocchiglia S Zhdanov AV Tambuwala MM Cummins EP Monfared M PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells Proc Natl Acad Sci U S A 2009 106 2188 2193 19179292 PMC2632715
  82. [102]Zhang H Gao P Fukuda R Kumar G Krishnamachary B Zeller KI HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity Cancer Cell 2007 11 407 420 17482131
  83. [103]Lee IH Cao L Mostoslavsky R Lombard DB Liu J Bruns NE A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy Proc Natl Acad Sci U S A 2008 105 3374 3379 18296641 PMC2265142
  84. [105]Shin JH Ko HS Kang H Lee Y Lee YI Pletinkova O PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease Cell 2011 144 689 702 21376232 PMC3063894
  85. [106]Yamamoto H Williams EG Mouchiroud L Canto C Fan W Downes M NCoR1 is a conserved physiological modulator of muscle mass and oxidative function Cell 2011 147 827 839 22078881 PMC3225739
  86. [109]Cunningham JT Rodgers JT Arlow DH Vazquez F Mootha VK Puigserver P mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex Nature 2007 450 736 740 18046414
  87. [110]Tsunemi T Ashe TD Morrison BE Soriano KR Au J Roque RA PGC-1alpha rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function Science translational medicine 2012 4 142ra97 PMC4096245 22786682
  88. [112]Scott I Webster BR Chan CK Okonkwo JU Han K Sack MN GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy J Biol Chem 2014 289 2864 2872 24356961 PMC3908418
  89. [113]Pfeifer U Scheller H A morphometric study of cellular autophagy including diurnal variations in kidney tubules of normal rats J Cell Biol 1975 64 608 621 1171105 PMC2109538
  90. [114]Reme CE Sulser M Diurnal variation of autophagy in rod visual cells in the rat Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie Albrecht von Graefe's archive for clinical and experimental ophthalmology 1977 203 261 270 303474
  91. [115]Ma D Panda S Lin JD Temporal orchestration of circadian autophagy rhythm by C/EBPbeta EMBO J 2011 30 4642 4651 21897364 PMC3243590
  92. [116]Cali T Ottolini D Negro A Brini M Enhanced parkin levels favor ER-mitochondria crosstalk and guarantee Ca(2+) transfer to sustain cell bioenergetics Biochim Biophys Acta 2013 1832 495 508 23313576
  93. [117]Suen DF Narendra DP Tanaka A Manfredi G Youle RJ Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells Proc Natl Acad Sci U S A 2010 107 11835 11840 20547844 PMC2900690
  94. [118]Bray MS Young ME Diurnal variations in myocardial metabolism Cardiovasc Res 2008 79 228 237 18304930
  95. [119]Bray MS Shaw CA Moore MW Garcia RA Zanquetta MM Durgan DJ Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression Am J Physiol Heart Circ Physiol 2008 294 H1036 H1047 18156197
  96. [120]Young ME Razeghi P Cedars AM Guthrie PH Taegtmeyer H Intrinsic diurnal variations in cardiac metabolism and contractile function Circ Res 2001 89 1199 1208 11739286
  97. [121]Ma D Li S Molusky MM Lin JD Circadian autophagy rhythm: a link between clock and metabolism? Trends in endocrinology and metabolism: TEM 2012 23 319 325 22520961 PMC3389582
  98. [122]Troncoso R Diaz-Elizondo J Espinoza SP Navarro-Marquez MF Oyarzun AP Riquelme JA Regulation of cardiac autophagy by insulin-like growth factor 1 IUBMB Life 2013 65 593 601 23671040
  99. [123]Liesa M Shirihai OS Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure Cell Metab 2013 17 491 506 23562075 PMC5967396
  100. [126]Giricz Z Mentzer RM Jr Gottlieb RA Autophagy, myocardial protection, and the metabolic syndrome J Cardiovasc Pharmacol 2012 60 125 132 22472909 PMC3419804
  101. [127]Xu X Ren J Unmasking the janus faces of autophagy in obesity-associated insulin resistance and cardiac dysfunction Clinical and experimental pharmacology & physiology 2012 39 200 208 22053892
  102. [128]Sciarretta S Zhai P Shao D Maejima Y Robbins J Volpe M Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome Circulation 2012 125 1134 146 22294621 PMC3337789
  103. [129]Laker RC Xu P Ryall KA Sujkowski A Kenwood BM Chain KH A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo J Biol Chem 2014 289 12005 12015 24644293 PMC4002107
  104. [130]Ferree AW Trudeau K Zik E Benador IY Twig G Gottlieb RA MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age Autophagy 2013 9 1887 1896 24149000 PMC4028338
  105. [131]Zhang J Liu J Liu L McKeehan WL Wang F The fibroblast growth factor signaling axis controls cardiac stem cell differentiation through regulating autophagy Autophagy 2012 8 690 691 22302007 PMC3405844
  106. [132]Sanchez AM Candau RB Bernardi H FoxO transcription factors: their roles in the maintenance of skeletal muscle homeostasis Cell Mol Life Sci 2014 71 1657 1671 24232446 PMC11113648
  107. [133]Sanchez AM Bernardi H Py G Candau R Autophagy is essential to support skeletal muscle plasticity in response to endurance exercise Am J Physiol Regul Integr Comp Physiol 2014 25121614
  108. [134]Zhang J Liu J Huang Y Chang JY Liu L McKeehan WL FRS2alpha-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity Circ Res 2012 110 e29 e39 22207710 PMC3677753
  109. [137]de Brito OM Scorrano L Mitofusin 2 tethers endoplasmic reticulum to mitochondria Nature 2008 456 605 610 19052620
  110. [138]Zhao T Huang X Han L Wang X Cheng H Zhao Y Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes J Biol Chem 2012 287 23615 23625 22619176 PMC3390636
  111. [139]Siddall HK Yellon DM Ong SB Mukherjee UA Burke N Hall AR Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury PLoS One 2013 8 e62400 23638067 PMC3639249
  112. [140]Murry CE Jennings RB Reimer KA Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium Circulation 1986 74 1124 1136 3769170
  113. [141]Zhao ZQ Corvera JS Halkos ME Kerendi F Wang NP Guyton RA Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning American journal of physiology Heart and circulatory physiology 2003 285 H579 H588 12860564
  114. [142]Han Z Cao J Song D Tian L Chen K Wang Y Autophagy is involved in the cardioprotection effect of remote limb ischemic postconditioning on myocardial ischemia/reperfusion injury in normal mice, but not diabetic mice PLoS One 2014 9 e86838 24466263 PMC3900658
  115. [143]Huang C Yitzhaki S Perry CN Liu W Giricz Z Mentzer RM Jr Autophagy induced by ischemic preconditioning is essential for cardioprotection J Cardiovasc Transl Res 2010 3 365 373 20559777 PMC2899015
  116. [144]Wei C Li H Han L Zhang L Yang X Activation of autophagy in ischemic postconditioning contributes to cardioprotective effects against ischemia/reperfusion injury in rat hearts J Cardiovasc Pharmacol 2013 61 416 422 23364609
  117. [145]Gao L Jiang T Guo J Liu Y Cui G Gu L Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats PLoS One 2012 7 e46092 23029398 PMC3461004
  118. [146]Qi ZF Luo YM Liu XR Wang RL Zhao HP Yan F AKT/GSK3beta-Dependent Autophagy Contributes to the Neuroprotection of Limb Remote Ischemic Postconditioning in the Transient Cerebral Ischemic Rat Model CNS neuroscience & therapeutics 2012 965 973 23191937 PMC6493377
  119. [147]Sala-Mercado JA Wider J Undyala VV Jahania S Yoo W Mentzer RM Jr Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury Circulation 2010 122 S179 S184 20837911 PMC3355994
  120. [148]Shinmura K Tamaki K Sano M Murata M Yamakawa H Ishida H Impact of long-term caloric restriction on cardiac senescence: caloric restriction ameliorates cardiac diastolic dysfunction associated with aging J Mol Cell Cardiol 2011 50 117 127 20977912
  121. [149]Xie M Kong Y Tan W May H Battiprolu PK Pedrozo Z Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy Circulation 2014 129 1139 1151 24396039 PMC3984913
  122. [150]Dutta D Xu J Kim JS Dunn WA Jr Leeuwenburgh C Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity Autophagy 2013 9 328 344 23298947 PMC3590254
  123. [151]Sciarretta S Volpe M Sadoshima J Mammalian target of rapamycin signaling in cardiac physiology and disease Circ Res 2014 114 549 564 24481845 PMC3995130
  124. [152]Xu X Hua Y Nair S Bucala R Ren J Macrophage migration inhibitory factor deletion exacerbates pressure overload-induced cardiac hypertrophy through mitigating autophagy Hypertension 2014 63 490 499 24366076 PMC3929844
  125. [153]Giricz Z Mentzer RM Jr Gottlieb RA Autophagy, Myocardial Protection and the Metabolic Syndrome J Cardiovasc Pharmacol 2012 [Epub ahead of print]. PMC3419804 22472909
  126. [154]Ren SY Xu X Role of autophagy in metabolic syndrome-associated heart disease Biochim Biophys Acta 2014 PMC4221581 24810277
  127. [155]Kobayashi S Liang Q Autophagy and mitophagy in diabetic cardiomyopathy Biochim Biophys Acta 2014 24882754
  128. [156]Chess DJ Stanley WC Role of diet and fuel overabundance in the development and progression of heart failure Cardiovasc Res 2008 79 269 278 18343896
  129. [157]Mozaffari MS Schaffer SW Myocardial ischemic-reperfusion injury in a rat model of metabolic syndrome Obesity (Silver Spring, Md) 2008 16 2253 2258 18719642
  130. [158]Essop MF Anna Chan WY Valle A Garcia-Palmer FJ Du Toit EF Impaired contractile function and mitochondrial respiratory capacity in response to oxygen deprivation in a rat model of pre-diabetes Acta physiologica 2009 197 289 296 19645752
  131. [159]Yu L Fink BD Herlein JA Oltman CL Lamping KG Sivitz WI Dietary fat, fatty acid saturation and mitochondrial bioenergetics J Bioenerg Biomembr 2014 46 33 44 24121995 PMC3955408
  132. [160]Sin J Puccini JM Huang C Konstandin MH Gilbert PE Sussman MA The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development PLoS pathogens 2014 10 e1004249 25079373 PMC4117602
  133. [162]Dirks-Naylor AJ The role of autophagy in doxorubicin-induced cardiotoxicity Life sciences 2013 93 913 916 24404586
  134. [163]Wang X Wang XL Chen HL Wu D Chen JX Wang XX Ghrelin inhibits doxorubicin cardiotoxicity by inhibiting excessive autophagy through AMPK and p38-MAPK Biochem Pharmacol 2014 88 334 350 24522112
  135. [164]Kawaguchi T Takemura G Kanamori H Takeyama T Watanabe T Morishita K Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes Cardiovasc Res 2012 96 456 465 22952253
  136. [166]Sishi BJ Loos B van Rooyen J Engelbrecht AM Autophagy upregulation promotes survival and attenuates doxorubicin-induced cardiotoxicity Biochem Pharmacol 2013 85 124 134 23107818
  137. [167]Xu X Bucala R Ren J Macrophage migration inhibitory factor deficiency augments doxorubicin-induced cardiomyopathy Journal of the American Heart Association 2013 2 e000439 24334905 PMC3886760
  138. [168]Li S Wang W Niu T Wang H Li B Shao L Nrf2 deficiency exaggerates doxorubicin-induced cardiotoxicity and cardiac dysfunction Oxidative medicine and cellular longevity 2014 2014 748524 24895528 PMC4033424
  139. [169]Neary MT Ng KE Ludtmann MH Hall AR Piotrowska I Ong SB Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function J Mol Cell Cardiol 2014 74 340 352 24984146 PMC4121533
  140. [170]Mei Z Wang X Liu W Gong J Gao X Zhang T Mitochondrial adaptations during myocardial hypertrophy induced by abdominal aortic constriction Cardiovasc Pathol 2014 23 283 288 24972527
  141. [171]Karamanlidis G Garcia Menendez L Kolwicz SC Jr Lee CF Tian R Promoting PGC1alpha-driven Mitochondrial Biogenesis Is Detrimental In Pressure Overloaded Mouse Hearts Am J Physiol Heart Circ Physiol 2014 PMC4217009 25172896
  142. [172]Russell LK Mansfield CM Lehman JJ Kovacs A Courtois M Saffitz JE Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner Circ Res 2004 94 525 533 14726475
  143. [173]Zhang X Li ZL Crane JA Jordan KL Pawar AS Textor SC Valsartan regulates myocardial autophagy and mitochondrial turnover in experimental hypertension Hypertension 2014 64 87 93 24752430 PMC4057304
  144. [174]Ma X Liu H Foyil SR Godar RJ Weinheimer CJ Hill JA Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia-Reperfusion Injury Circulation 2012 PMC3397471 22592897
  145. [176]Miyata N Steffen J Johnson ME Fargue S Danpure CJ Koehler CM Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1 Proc Natl Acad Sci U S A 2014 PMC4210028 25237136
  146. [177]Mohamed JS Hajira A Pardo PS Boriek AM MicroRNA-149 inhibits PARP-2 and promotes mitochondrial biogenesis via SIRT-1/PGC-1alpha network in skeletal muscle Diabetes 2014 63 1546 1559 24757201
  147. [178]Kang T Lu W Xu W Anderson L Bacanamwo M Thompson W MicroRNA-27 (miR-27) targets prohibitin and impairs adipocyte differentiation and mitochondrial function in human adipose-derived stem cells J Biol Chem 2013 288 34394 34402 24133204 PMC3843054
  148. [179]Cheng X Ku CH Siow RC Regulation of the Nrf2 antioxidant pathway by microRNAs: New players in micromanaging redox homeostasis Free Radic Biol Med 2013 64 4 11 23880293
  149. [180]Wang Z Wang N Liu P Chen Q Situ H Xie T MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin Oncotarget 2014 5 7013 7026 25026296 PMC4196180
  150. [181]Song L Su M Wang S Zou Y Wang X Wang Y MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1 J Cell Mol Med 2014 PMC4224559 25209900
  151. [182]Seca H Lima RT Lopes-Rodrigues V Guimaraes JE Almeida GM Vasconcelos MH Targeting miR-21 induces autophagy and chemosensitivity of leukemia cells Current drug targets 2013 14 1135 1143 23834154
  152. [183]Pan W Zhong Y Cheng C Liu B Wang L Li A MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy PLoS One 2013 8 e53950 23326547 PMC3541228
  153. [184]Yu Y Yang L Zhao M Zhu S Kang R Vernon P Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells Leukemia 2012 26 1752 1760 22395361

Cited by

Sorted by citations

Authors
Andres, A. M., Stotland, A., Queliconi, B. B., & Gottlieb, R. A.
Affiliations
Cedars-Sinai Smidt Heart Institute (US)
Corresponding author
Gottlieb, Roberta A.
ORCID
Venue
Journal of Molecular and Cellular Cardiology
Publisher
Elsevier BV
Published
2015-01
Volume
78
Pages
62-72
ISSN
0022-2828 (ISSN-L)
DOI
10.1016/j.yjmcc.2014.10.003
PMC
PMC4268279
OpenAlex
W2074821253
Cited by
78
References
31
Citations by year
2026: 3 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 9 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 11 · 2016: 9 · 2015: 7 · 2014: 2
FWCI
1.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Molecular and Cellular Cardiology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH (P01 HL112730)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords
mitophagy, mitochondrial biogenesis, mitochondrial turnover, cardiac pathophysiology, mitochondrial dysfunction, cellular stress response, heart disease, mitochondrial homeostasis
MeSH terms
Animals, Heart, Humans, Mitochondria, Heart, Myocardium, Mitochondrial Turnover, Mitophagy

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