The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Vascular endothelial growth factor stimulates skeletal muscle regeneration in Vivo
Open accessAbstract
Vascular endothelial growth factor (VEGF) is a major regulator of blood vessel formation during development and in the adult organism. Recent evidence indicates that this factor also plays an important role in sustaining the proliferation and differentiation of different cell types, including progenitor cells of different tissues, including bone marrow, bone, and the central nervous system. Here we show that the delivery of the 165-aa isoform of VEGF-A cDNA using an adeno-associated virus (AAV) vector exerts a powerful effect on skeletal muscle regeneration in vivo. Following ischemia-, glycerol-, or cardiotoxin-induced damage in mouse skeletal muscle, the delivery of AAV-VEGF markedly improved muscle fiber reconstitution with a dose-dependent effect. The expression of both VEGF receptor-1 (VEGFR-1) and VEGFR-2 was upregulated both in the satellite cells of the damaged muscles and during myotube formation in vitro; the VEGF effect was mediated by the VEGFR-2, since the transfer of PlGF, a VEGF family member interacting with the VEGFR-1, was ineffective. These results are consistent with the observation that VEGF promotes the growth of myogenic fibers and protects the myogenic cells from apoptosis in vitro and prompt a therapeutic use for VEGF gene transfer in a variety of muscular disorders.
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Cites
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Cited by
Satellite Cells and the Muscle Stem Cell Niche
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Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
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Endothelial cells and VEGF in vascular development
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Aberrant repair and fibrosis development in skeletal muscle
Mann, C. J., Perdiguero, E., Kharraz, Y., Aguilar, S., Pessina, P., Serrano, A. L., & Muñoz-Cánoves, P. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-21 · Cited by 853
“Interestingly, there is the suggestion that the type of injury in acute models may drive the repair response towards more fibrotic or more adipogenic repair, for example after glycerol injury and acute ischemia, respectively [68,69], although the mechanisms have not been extensively investigated.”
Background
Metadata
- Authors
- Arsic, N., Zacchigna, S., Zentilin, L., Ramirez-Correa, G., Pattarini, L., Salvi, A., Sinagra, G., & Giacca, M.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 10
- Issue
- 5
- Pages
- 844-854
- ISSN
- 1525-0016 (ISSN-L)
- OpenAlex
- W2057242413
- Cited by
- 349
- References
- 47
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Arsic, N., Zacchigna, S., Zentilin, L., Ramirez-Correa, G., Pattarini, L., Salvi, A., Sinagra, G., & Giacca, M. (2004). Vascular endothelial growth factor stimulates skeletal muscle regeneration in Vivo. Molecular Therapy. https://doi.org/10.1016/j.ymthe.2004.08.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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