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Cited by 398

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model

Open access
Kurozumi, Kazuhiko, Nakamura, Kiminori, Tamiya, Takashi, Kawano, Yutaka, Ishii, Keiji, Kobune, Masayoshi, Hirai, Sachie, Uchida, Hiroaki, Sasaki, Katsunori, Ito, Yoshinori, Kato, Kazunori, Honmou, Osamu, Houkin, Kiyohiro, Date, Isao, Hamada, Hirofumi·2005·Molecular Therapy
DOI 10.1016/j.ymthe.2004.09.020
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Abstract

Mesenchymal stem cells (MSC) were reported to ameliorate functional deficits after stroke in rats, with some of this improvement possibly resulting from the action of cytokines secreted by these cells. To enhance such cytokine effects, we previously transfected the telomerized human MSC with the BDNF gene using a fiber-mutant adenovirus vector and reported that such treatment contributed to improved ischemic recovery in a rat transient middle cerebral artery occlusion (MCAO) model. In the present study, we investigated whether other cytokines in addition to BDNF, i.e., GDNF, CNTF, or NT3, might have a similar or greater effect in this model. Rats that received MSC-BDNF (P < 0.05) or MSC-GDNF (P < 0.05) showed significantly more functional recovery as demonstrated by improved behavioral test results and reduced ischemic damage on MRI than did control rats 7 and 14 days following MCAO. On the other hand, rats that received MSC-CNTF or MSC-NT3 showed neither functional recovery nor ischemic damage reduction compared to control rats. Thus, MSC transfected with the BDNF or GDNF gene resulted in improved function and reduced ischemic damage in a rat model of MCAO. These data suggest that gene-modified cell therapy may be a useful approach for the treatment of stroke.

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Metadata

Authors
Kurozumi, K., Nakamura, K., Tamiya, T., Kawano, Y., Ishii, K., Kobune, M., Hirai, S., Uchida, H., Sasaki, K., Ito, Y., Kato, K., Honmou, O., Houkin, K., Date, I., & Hamada, H.
Venue
Molecular Therapy
Publisher
Elsevier BV
Published
2005-01
Volume
11
Issue
1
Pages
96-104
ISSN
1525-0016 (ISSN-L)
DOI
10.1016/j.ymthe.2004.09.020
OpenAlex
W2020709967
Cited by
398
References
49
FWCI
6.78
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model. https://app.cochat.ai/papers/10.1016/j.ymthe.2004.09.020
The paper
Kurozumi, K., Nakamura, K., Tamiya, T., Kawano, Y., Ishii, K., Kobune, M., Hirai, S., Uchida, H., Sasaki, K., Ito, Y., Kato, K., Honmou, O., Houkin, K., Date, I., & Hamada, H. (2005). Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model. Molecular Therapy. https://doi.org/10.1016/j.ymthe.2004.09.020

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.