The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Bone Marrow as a Potential Source of Hepatic Oval Cells
Abstract
Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
Ferrari, G., Cusella–, G., Angelis, D., Coletta, M., Paolucci, E., Stornaiuolo, A., Cossu, G., & Mavilio, F. (1998) · Science · doi:10.1126/science.279.5356.1528 · Cited by 2,720
In vivo differentiation of rat liver oval cells into hepatocytes.
Evarts, R. P., Nagy, P., Nakatsukasa, H., Marsden, E. R., & Thorgeirsson, S. S. (1989) · PubMed · Cited by 321
Presence of hematopoietic stem cells in the adult liver
Taniguchi, H., Toyoshima, T., Fukao, K., & Nakauchi, H. (1996) · Nature Medicine · doi:10.1038/nm0296-198 · Cited by 312
Fujio, K., Evarts, R. P., Hu, Z., Marsden, E. R., & Thorgeirsson, S. S. (1994) · PubMed · Cited by 286
MURASE, N., STARZL, T. E., TANABE, M., FUJISAKI, S., MIYAZAWA, H., YE, Q., DELANEY, C. P., FUNG, J. J., & DEMETRIS, A. J. (1995) · Transplantation · doi:10.1097/00007890-199507000-00009 · Cited by 220
Self-citationPetersen, B. E., Zajac, V. F., & Michalopoulos, G. K. (1998) · Hepatology · doi:10.1002/hep.510270419 · Cited by 203
Self-citationTissue architecture: the ultimate regulator of epithelial function?
Hagios, C., Lochter, A., & Bissell, M. J. (1998) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1998.0250 · Cited by 139
Hepatic Stem Cell Compartment: Activation and Lineage Commitment
Thorgeirsson, S. S., Evarts, R. P., Bisgaard, H. C., Fujio, K., & Hu, Z. (1993) · Experimental Biology and Medicine · doi:10.3181/00379727-204-43661 · Cited by 102
Murase, N., Starzl, T. E., Ye, Q., Tsamandas, A. C., Thomson, A. W., Rao, A. S., & Demetris, A. J. (1996) · Transplantation · doi:10.1097/00007890-199601150-00001 · Cited by 91
Self-citationBile ductular damage induced by methylene dianiline inhibits oval cell activation.
Petersen, B. E., Zajac, V. F., & Michalopoulos, G. K. (1997) · Europe PMC (PubMed Central) · Cited by 87
Self-citation
Cited by
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M. (2000) · Nature Medicine · doi:10.1038/81326 · Cited by 2,314
Liver regeneration: from myth to mechanism
Taub, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1489 · Cited by 1,567
Michalopoulos, G. K. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21172 · Cited by 1,384
Role for Interferon-γ in the Immunomodulatory Activity of Human Bone Marrow Mesenchymal Stem Cells
Krampera, M., Cosmi, L., Angeli, R., Pasini, A., Liotta, F., Andreini, A., Santarlasci, V., Mazzinghi, B., Pizzolo, G., Vinante, F., et al. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0008 · Cited by 1,311
Metadata
- Authors
- Petersen, B. E., Bowen, W. C., Patrene, K. D., Mars, W. M., Sullivan, A. K., Murase, N., Boggs, S. S., Greenberger, J. S., & Goff, J. P.
- Venue
- Science
- Published
- 1999-05-14
- Volume
- 284
- Issue
- 5417
- Pages
- 1168-1170
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982022033
- Cited by
- 2,378
- References
- 13
- FWCI
- 76.09
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Bone Marrow as a Potential Source of Hepatic Oval Cells. https://app.cochat.ai/papers/10.1126/science.284.5417.1168
- The paper
- Petersen, B. E., Bowen, W. C., Patrene, K. D., Mars, W. M., Sullivan, A. K., Murase, N., Boggs, S. S., Greenberger, J. S., & Goff, J. P. (1999). Bone Marrow as a Potential Source of Hepatic Oval Cells. Science. https://doi.org/10.1126/science.284.5417.1168
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
