Cell transplantation therapy for stroke
Abstract
No treatment currently exists to restore lost neurological function after stroke. A growing number of studies highlight the potential of stem cell transplantation as a novel therapeutic approach for stroke. In this review we summarize these studies, discuss potential mechanisms of action of the transplanted cells, and emphasize the need to determine parameters that are critical for transplantation success.
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Evidence that neurogenesis contributes to functional neurological recovery comes from studies with transgenic ablation of doublecortin-expressing neural precursor cells and from exogenous delivery of adult neural precursor cells, which reported impaired or enhanced recovery, respectively.
“Meanwhile, evidence that neuro genesis contributes to functional neurological recovery has been obtained in studies with transgenic ablation of neural precursor cells expressing the marker doublecortin43 and in studies with exogenous delivery of adult neural precursor cells,14,15,44 which reported impaired or enhanced neurological recovery, respectively.”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [44]
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- Authors
- Bliss, T., Guzman, R., Daadi, M., & Steinberg, G. K.
- Affiliations
- Stanford Medicine (US)
- Venue
- Stroke
- Published
- 2007-02
- Volume
- 38
- Issue
- 2
- Pages
- 817-826
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W1994334993
- Cited by
- 374
- References
- 105
- Citations by year
- 2025: 4 · 2024: 9 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 10 · 2018: 22 · 2017: 19 · 2016: 27 · 2015: 28 · 2014: 36 · 2013: 28 · 2012: 40
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (2R01 NS27292, 2P01 NS 37520, P01NS037520, R01NS027292)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- cell transplantation, stem cell transplantation, neurological recovery, mechanism of action
- MeSH terms
- Animals, Humans, Brain Tissue Transplantation, Cell Transplantation, Stroke, Stem Cell Transplantation
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