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Cited by 364

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Pro-inflammatory Microenvironment in the Lymph Node

Open access
Cheng, Lifang, Wang, Yuhua, Huang, Leaf·2017·Molecular Therapy
DOI 10.1016/j.ymthe.2017.02.007
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Abstract

Exosomes are small membrane-bound vesicular particles generated by most cells for intercellular communication and regulation. During biogenesis, specific lipids, RNAs, proteins, and carbohydrates are enriched and packaged into the vesicles so that the exosomal contents reflect not only the source but also the physiological conditions of the parental cells. These exosomes transport materials or signals to the target cells for diverse physiological purposes. Our study focused on the exosomes derived from M1-polarized, proinflammatory macrophages for the possibility of using M1 exosomes as an immunopotentiator for a cancer vaccine. The M1 exosomes displayed a tropism toward lymph nodes after subcutaneous injection, primarily taken up by the local macrophages and dendritic cells, and they induced the release of a pool of Th1 cytokines. We found that M1, but not M2, exosomes enhanced activity of lipid calcium phosphate (LCP) nanoparticle-encapsulated Trp2 vaccine, and they induced a stronger antigen-specific cytotoxic T cell response. The M1 exosomes proved to be a more potent immunopotentiator than CpG oligonucleotide when used with LCP nanoparticle vaccine in a melanoma growth inhibition study. Thus, our study indicated that exosomes derived from M1-polarized macrophages could be used as a vaccine adjuvant.

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Metadata

Authors
Cheng, L., Wang, Y., & Huang, L.
Venue
Molecular Therapy
Publisher
Elsevier BV
Published
2017-07
Volume
25
Issue
7
Pages
1665-1675
ISSN
1525-0016 (ISSN-L)
DOI
10.1016/j.ymthe.2017.02.007
OpenAlex
W2594400638
Cited by
364
References
32
FWCI
8.83
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Pro-inflammatory Microenvironment in the Lymph Node. https://app.cochat.ai/papers/10.1016/j.ymthe.2017.02.007
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Cheng, L., Wang, Y., & Huang, L. (2017). Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Pro-inflammatory Microenvironment in the Lymph Node. Molecular Therapy. https://doi.org/10.1016/j.ymthe.2017.02.007

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.