The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression
Abstract
Comprehensive analysis of the gene expression profiles associated with human monocyte-to-macrophage differentiation and polarization toward M1 or M2 phenotypes led to the following main results: 1) M-CSF-driven monocyte-to-macrophage differentiation is associated with activation of cell cycle genes, substantiating the underestimated proliferation potential of monocytes. 2) M-CSF leads to expression of a substantial part of the M2 transcriptome, suggesting that under homeostatic conditions a default shift toward M2 occurs. 3) Modulation of genes involved in metabolic activities is a prominent feature of macrophage differentiation and polarization. 4) Lipid metabolism is a main category of modulated transcripts, with expected up-regulation of cyclo-oxygenase 2 in M1 cells and unexpected cyclo-oxygenase 1 up-regulation in M2 cells. 5) Each step is characterized by a different repertoire of G protein-coupled receptors, with five nucleotide receptors as novel M2-associated genes. 6) The chemokinome of polarized macrophages is profoundly diverse and new differentially expressed chemokines are reported. Thus, transcriptome profiling reveals novel molecules and signatures associated with human monocyte-to-macrophage differentiation and polarized activation which may represent candidate targets in pathophysiology.
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“Despite a number of genomic studies analyzing macrophage activation in response to bacteria, TLR ligands, and M1 or M2 stimuli, to date there have been no attempts to reconcile these observations by building new and integrative models of macrophage activation”
From Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation (2014) · cites this paper as Martinez et al., 2006
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Sorted by citations
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Macrophage plasticity and polarization: in vivo veritas
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Self-citationMacrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
Self-citationMacrophage activation and polarization
Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160
Self-citation
Metadata
- Authors
- Martinez, F. O., Gordon, S., Locati, M., & Mantovani, A.
- Affiliations
- Istituto Clinico Humanitas , Rozzano ,
- Sir William Dunn School of Pathology, University of Oxford , Oxford ,
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-11
- Volume
- 177
- Issue
- 10
- Pages
- 7303-7311
- ISSN
- 0022-1767
- 1550-6606
- Cited by
- 2,125
- References
- 8
- Language
- en
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- Martinez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006). Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression. The Journal of Immunology. https://doi.org/10.4049/jimmunol.177.10.7303
