Development of Monocytes, Macrophages, and Dendritic Cells
Open accessAbstract
Development of Myeloid Immune Cells: As leukocytes develop to maturity, they proceed through an array of phenotypically distinct intermediates. For T and B lymphocyte populations, the different developmental stages, anatomical locations, and cell signals required for progression are well established. However, until recently, much less has been known about how development proceeds in the myeloid lineage, which includes monocytes, macrophages, and dendritic cells. Geissmann et al. (p. 656 ) review our current understanding of myeloid lineage development and describe the developmental pathways and cues that drive differentiation.
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IRF8 and CEBPA have been implicated as key regulators of monocyte network.
“Since IRF8 and CEBPA have been implicated as key regulators of monocyte network, we specifically measured the expression changes after the knockdown (16,18,28,29).”
From Establishment of single-cell screening system for the rapid identification of transcriptional modulators involved in direct cell reprogramming (2012) · cites this paper as [29]
In “Transcriptional control of lineage commitment in the mononuclear phagocyte system” (page unavailable), the review says ectopic IRF8 expression can drive monocyte/macrophage fates. It also discusses C/EBPα in a related lineage choice, but describes it as promoting neutrophil fate rather than establishing it as a key regulator of a monocyte network. (LLM, conf=0.83)
Experimental — accuracy not yet measuredMassive circulating monocytes are recruited into the lung and differentiate into macrophages.
“Massive circulating monocytes are recruited into the lung and differentiate into macrophages 9.”
From Nicotinamide phosphoribosyltransferase prompts bleomycin-induced pulmonary fibrosis by driving macrophage M2 polarization in mice (2024) · cites this paper as [9]
The Abstract (page not available in our copy) says circulating monocytes can migrate into tissues during infection and differentiate into macrophages during inflammation. It does not say that this occurs specifically in the lung or describe the recruitment as massive. (LLM, conf=0.86)
Experimental — accuracy not yet measuredInfiltrating monocytes expand locally and give rise to macrophages and inflammatory dendritic cells, but are unable to generate resident microglia.
“These infiltrating monocytes expand locally and give rise to macrophages and inflammatory dendritic cells [390], but they are unable to generate resident microglia.”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [390]
The section ‘Are monocytes effector cells or circulating precursors?’ (page not provided) says inflammatory monocytes give rise to macrophages and dendritic cells, including inflammatory dendritic cells. The cited paper does not say that infiltrating monocytes expand locally. The microglia clause follows the citation and is not attributed to this source by the citing sentence. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThe main •NO-emitting cells are macrophages, neutrophils, monocytes, and mature dendritic cells, by expressing iNOS.
“The main •NO-emitting cells are macrophages, neutrophils, monocytes, and mature dendritic cells, by expressing the iNOS [111].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [111]
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Zlatanova, I., Pinto, C., Bonnin, P., Mathieu, J. R. R., Bakker, W., Vilar, J., Lemitre, M., Voehringer, D., Vaulont, S., Peyssonnaux, C., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.034545 · Cited by 81 · see citing works
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Can DCs be distinguished from macrophages by molecular signatures?
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Nitric oxide-mediated tumoricidal activity of murine microglial cells
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“Discussion Microglia are the major immune effector cells of the CNS and are commonly called the macrophages of the brain [1,2].”
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Childhood Obesity: Immune Response and Nutritional Approaches
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Therapeutic Prospects of mRNA-Based Gene Therapy for Glioblastoma
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- Authors
- Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K.
- Affiliations
- Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King's College London, Great Maze Pond, London SE1 1UL, UK.
- University Hospital Zurich (CH)
- Weizmann Institute of Science (IL)
- Centre National de la Recherche Scientifique (FR)
- Department of Gene and Cell Medicine and Institute for Immunology, Icahn Medical Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
- La Jolla Institute for Immunology (US)
- Corresponding author
- Ley, Klaus
- Venue
- Science
- Published
- 2010-02-05
- Volume
- 327
- Issue
- 5966
- Pages
- 656-661
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2887389
- OpenAlex
- W2100820895
- Cited by
- 3,049
- References
- 82
- Citations by year
- 2026: 66 · 2025: 112 · 2024: 153 · 2023: 130 · 2022: 174 · 2021: 166 · 2020: 162 · 2019: 180 · 2018: 165 · 2017: 192 · 2016: 195 · 2015: 218 · 2014: 283 · 2013: 268 · 2012: 270
- FWCI
- 20.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL058108)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- monocytes, macrophages, dendritic cells, cell development, lineage relationships, innate immunity, inflammation, adaptive immune response, immunological memory, immune tolerance, tissue macrophages, cell differentiation
- MeSH terms
- Animals, Dendritic Cells, Homeostasis, Humans, Inflammation, Macrophages, Monocytes, Phagocytosis, Transcription, Genetic, Cytokines, Cell Lineage, Myeloid Progenitor Cells, Myelopoiesis, Cell Proliferation, Mice
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