The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
RETRACTED: Exosome-Mediated miR-155 Transfer from Smooth Muscle Cells to Endothelial Cells Induces Endothelial Injury and Promotes Atherosclerosis
Open accessAbstract
The vascular response to pro-atherosclerotic factors is a multifactorial process involving endothelial cells (ECs), macrophages (MACs), and smooth muscle cells (SMCs), although the mechanism by which these cell types communicate with each other in response to environmental cues is yet to be understood. Here, we show that miR-155, which is significantly expressed and secreted in Krüppel-like factor 5 (KLF5)-overexpressing vascular smooth muscle cells (VSMCs), is a potent regulator of endothelium barrier function through regulating endothelial targeting tight junction protein expression. VSMCs-derived exosomes mediate the transfer of KLF5-induced miR-155 from SMCs to ECs, which, in turn, destroys tight junctions and the integrity of endothelial barriers, leading to an increased endothelial permeability and enhanced atherosclerotic progression. Moreover, overexpression of miR-155 in ECs inhibits endothelial cell proliferation/migration and re-endothelialization in vitro and in vivo and thus increases vascular endothelial permeability. Blockage of the exosome-mediated transfer of miR-155 between these two cells may serve as a therapeutic target for atherosclerosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis
Zhou, W., Fong, M. Y., Min, Y., Somlo, G., Liu, L., Palomares, M. R., Yu, Y., Chow, A., O’Connor, S. T. F., Chin, A. R., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.007 · Cited by 1,476
Cited by
Cell-cell communication: New insights and clinical implications
Su, J., Song, Y., Zhu, Z., Huang, X., Fan, J., Qiao, J., & Mao, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01888-z · Cited by 433
Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome
Sork, H., Corso, G., Krjutskov, K., Johansson, H. J., Nordin, J. Z., Wiklander, O. P. B., Lee, Y. X. F., Westholm, J. O., Lehtiö, J., Wood, M. J. A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-28485-9 · Cited by 140
Circulating exosomes in cardiovascular disease: Novel carriers of biological information
Liu, Q., Piao, H., Wang, Y., Zheng, D., & Wang, W. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111148 · Cited by 70
Yao, Y., Sun, W., Sun, Q., Jing, B., Liu, S., Liu, X., Shen, G., Chen, R., & Wang, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02205 · Cited by 70
RetractedmiR-155 Dysregulation and Therapeutic Intervention in Multiple Sclerosis
McCoy, C. E. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-10-5987-2_5 · Cited by 46
Metadata
- Authors
- Zheng, B., Yin, W.-N., Suzuki, T., Zhang, X.-H., Zhang, Y., Song, L.-L., Jin, L.-S., Zhan, H., Zhang, H., Li, J.-S., & Wen, J.-K.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 25
- Issue
- 6
- Pages
- 1279-1294
- ISSN
- 1525-0016 (ISSN-L)
- OpenAlex
- W2603510655
- Cited by
- 276
- References
- 1
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: RETRACTED: Exosome-Mediated miR-155 Transfer from Smooth Muscle Cells to Endothelial Cells Induces Endothelial Injury and Promotes Atherosclerosis. https://app.cochat.ai/papers/10.1016/j.ymthe.2017.03.031
- The paper
- Zheng, B., Yin, W.-N., Suzuki, T., Zhang, X.-H., Zhang, Y., Song, L.-L., Jin, L.-S., Zhan, H., Zhang, H., Li, J.-S., & Wen, J.-K. (2017). RETRACTED: Exosome-Mediated miR-155 Transfer from Smooth Muscle Cells to Endothelial Cells Induces Endothelial Injury and Promotes Atherosclerosis. Molecular Therapy. https://doi.org/10.1016/j.ymthe.2017.03.031
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
