CoChat
Sign Up
Cited by 70

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

RETRACTED: Platelet-Derived Exosomal MicroRNA-25-3p Inhibits Coronary Vascular Endothelial Cell Inflammation Through Adam10 via the NF-κB Signaling Pathway in ApoE−/− Mice

Yao, Ye, Sun, Weidong, Sun, Qingfeng, Jing, Bao, Liu, Siqi, Liu, Xinyu, Shen, Guanghui, Chen, Ru, Wang, Haiyang·2019·Frontiers in Immunology
DOI 10.3389/fimmu.2019.02205PMC PMC6783608
Open this paper in CoChat — free account

Abstract

Introduction: Coronary artery disease originates from the blockage of the inner walls of the coronary arteries due to a plaque buildup. Accumulating studies have highlighted the role of microRNAs (miRs) delivered by exosomes in the progression of coronary artery disease. Thus, the current study was to elucidate the role and mechanism by which miR-25-3p influences oxidized low density lipoprotein (ox-LDL)-induced coronary vascular endothelial cell (CVEC) inflammation. Methods: Primarily isolated CVECs were treated with ox-LDL to induce inflammation. Atherosclerosis models were induced in ApoE −/− mice and the peripheral blood platelet exosomes (PLT-Exo) were extracted and induced by thrombin, followed by co-culture with CVECs. The relationship between miR-25-3p and A disintegrin and metalloprotease 10 (Adam10) as well as the involvement of the NF-κB signaling pathway was evaluated. In order to evaluate the effect of PLT-Exo containing miR-25-3p on ox-LDL-induced CVEC inflammation, lipid accumulation and fibrosis, miR-25-3p mimic/inhibitor ( in vitro ), miR-25-3p agomir ( in vivo ), and si-Adam10 were delivered. Results: MiR-25-3p was expressed poorly in ox-LDL-induced CVECs and vascular tissues but exhibited high levels of expression in thrombin-induced PLT-Exo of atherosclerosis models of ApoE −/− mice. CVECs endocytosed PLT-Exo upregulated the miR-25-3p expression. Adam10 was identified as a target gene of miR-25-3p. The thrombin-induced activated PLT-Exo carrying miR-25-3p reduced Adam10 expression to inhibit ox-LDL-induced CVEC inflammation and lipid deposition through downregulating levels of α-smooth muscle actin, Collagen I a1, Collagen III a1, triglycerides, total cholesterol, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α. Furthermore, the NF-κB signaling pathway participated in the inhibitory effect of PLT-Exo carrying miR-25-3p. Conclusion: Collectively, PLT-Exo overexpressing miR-25-3p attenuates ox-LDL-induced CVEC inflammation in ApoE −/− mouse models of atherosclerosis.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fimmu.2019.02205This paper is marked retracted.

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 2 references

Research works printed but not linked: 43

  1. Liu, 2013, Periodic vs constant high glucose in inducing pro-inflammatory cytokine expression in human coronary artery endothelial cells, Inflamm Res, 62, 697, 10.1007/s00011-013-0623-2 · DOI
  2. Wang, 2018, CRISPR-Cas9 mediated gene knockout in human coronary artery endothelial cells reveals a pro-inflammatory role of TLR2, Cell Biol Int, 42, 187, 10.1002/cbin.10885 · DOI
  3. Ketelhuth, 2016, Adaptive response of T and B cells in atherosclerosis, Circ Res, 118, 668, 10.1161/CIRCRESAHA.115.306427 · DOI
  4. Indermuehle, 2011, Oxidized low-density lipoprotein cholesterol and coronary artery disease, Cardiology, 119, 106, 10.1159/000330939 · DOI
  5. Jansen, 2016, CD40 in coronary artery disease: a matter of macrophages?, Basic Res Cardiol, 111, 38, 10.1007/s00395-016-0554-5 · DOI
  6. Chen, 2013, Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway, Autophagy, 9, 2033, 10.4161/auto.26336 · DOI
  7. Safranow, 2016, Inflammation markers are associated with metabolic syndrome and ventricular arrhythmia in patients with coronary artery disease, Postepy Hig Med Dosw, 70, 56, 10.5604/17322693.1194612 · DOI
  8. Witwer, 2013, Standardization of sample collection, isolation and analysis methods in extracellular vesicle research, J Extracell Vesicles, 2, 20360, 10.3402/jev.v2i0.20360 · DOI
  9. Li, 2017, Thrombin-activated platelet-derived exosomes regulate endothelial cell expression of ICAM-1 via microRNA-223 during the thrombosis-inflammation response, Thromb Res, 154, 96, 10.1016/j.thromres.2017.04.016 · DOI
  10. Chevillet, 2014, Quantitative and stoichiometric analysis of the microRNA content of exosomes, Proc Natl Acad Sci USA, 111, 14888, 10.1073/pnas.1408301111 · DOI
  11. Sukma Dewi, 2017, Exosomal miR-142–3p is increased during cardiac allograft rejection and augments vascular permeability through down-regulation of endothelial RAB11FIP2 expression, Cardiovasc Res, 113, 440, 10.1093/cvr/cvw244 · DOI
  12. Yoshida, 2018, Clinical and functional significance of intracellular and extracellular microrna-25-3p in osteosarcoma, Acta Med Okayama, 72, 165, 10.18926/AMO/55857 · DOI
  13. Casadei, 2017, Exosome-derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression, Cancer Res, 77, 3846, 10.1158/0008-5472.CAN-16-2984 · DOI
  14. Zhang, 2018, miR-25-3p, positively regulated by transcription factor AP-2alpha, regulates the metabolism of C2C12 cells by targeting Akt1, Int J Mol Sci, 19, E773, 10.3390/ijms19030773 · DOI
  15. Sarkozy, 2018, A myriad of roles of miR-25 in health and disease, Oncotarget, 9, 21580, 10.18632/oncotarget.24662 · DOI · Paper page
  16. Haining, 2012, The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression, J Biol Chem, 287, 39753, 10.1074/jbc.M112.416503 · DOI · Paper page
  17. Wang, 2014, oxLDL-induced lipid accumulation in glomerular podocytes: role of IFN-gamma, CXCL16, and ADAM10, Cell Biochem Biophys, 70, 529, 10.1007/s12013-014-9952-1 · DOI
  18. Yu, 2017, NF-kappaB signaling pathway and its potential as a target for therapy in lymphoid neoplasms, Blood Rev, 31, 77, 10.1016/j.blre.2016.10.001 · DOI · Paper page
  19. Guo, 2018, The interplay of LncRNA ANRIL and miR-181b on the inflammation-relevant coronary artery disease through mediating NF-kappaB signalling pathway, J Cell Mol Med, 22, 5062, 10.1111/jcmm.13790 · DOI
  20. Jiang, 2018, Corin is highly expressed in atherosclerosis models, Biochem Biophys Res Commun, 504, 440, 10.1016/j.bbrc.2018.08.173 · DOI
  21. Sun, 2019, Platelet-derived exosomes affect the proliferation and migration of human umbilical vein endothelial cells via miR-126, Curr Vasc Pharmacol, 17, 379, 10.2174/1570161116666180313142139 · DOI
  22. Xiao, 2016, Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4, Cell Death Dis, 7, e2277, 10.1038/cddis.2016.181 · DOI · Paper page
  23. Ayuk, 2016, The role of photobiomodulation on gene expression of cell adhesion molecules in diabetic wounded fibroblasts in vitro, J Photochem Photobiol B, 161, 368, 10.1016/j.jphotobiol.2016.05.027 · DOI
  24. Song, 2012, Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice, Atherosclerosis, 221, 55, 10.1016/j.atherosclerosis.2011.11.043 · DOI
  25. Dai, 2016, Genetics of coronary artery disease and myocardial infarction, World J Cardiol, 8, 1, 10.4330/wjc.v8.i1.1 · DOI
  26. Vanhaverbeke, 2017, Functional role of cardiovascular exosomes in myocardial injury and atherosclerosis, Adv Exp Med Biol, 998, 45, 10.1007/978-981-10-4397-0_3 · DOI
  27. McDonald, 2014, Functional significance of macrophage-derived exosomes in inflammation and pain, Pain, 155, 1527, 10.1016/j.pain.2014.04.029 · DOI
  28. Li, 2017, [Advances in the research of effects of exosomes derived from stem cells on wound repair], Zhonghua Shao Shang Za Zhi, 33, 180, 10.3760/cma.j.issn.1009-2587.2017.03.013 · DOI
  29. Dotsenko, 2007, Platelet and leukocyte activation, atherosclerosis and inflammation in European and South Asian men, J Thromb Haemost, 5, 2036, 10.1111/j.1538-7836.2007.02711.x · DOI
  30. Li, 2016, miR-155 acts as an anti-inflammatory factor in atherosclerosis-associated foam cell formation by repressing calcium-regulated heat stable protein 1, Sci Rep, 6, 21789, 10.1038/srep21789 · DOI · Paper page
  31. Li, 2017, Overexpression of microRNA-138 alleviates human coronary artery endothelial cell injury and inflammatory response by inhibiting the PI3K/Akt/eNOS pathway, J Cell Mol Med, 21, 1482, 10.1111/jcmm.13074 · DOI
  32. Guo, 2018, miR152 inhibits rheumatoid arthritis synovial fibroblast proliferation and induces apoptosis by targeting ADAM10, Int J Mol Med, 42, 643, 10.3892/ijmm.2018.3636 · DOI
  33. Zhao, 2019, Exosomes derived from bone marrow mesenchymal stem cells overexpressing microRNA-25 protect spinal cords against transient ischemia, J Thorac Cardiovasc Surg., 157, 508, 10.1016/j.jtcvs.2018.07.095 · DOI
  34. Pienimaeki-Roemer, 2017, Transcriptomic profiling of platelet senescence and platelet extracellular vesicles, Transfusion, 57, 144, 10.1111/trf.13896 · DOI
  35. Zheng, 2017, Exosome-mediated miR-155 transfer from smooth muscle cells to endothelial cells induces endothelial injury and promotes atherosclerosis, Mol Ther, 25, 1279, 10.1016/j.ymthe.2017.03.031 · DOI
  36. Zhang, 2017, Genistein protects against Ox-LDL-induced inflammation through microRNA-155/SOCS1-mediated repression of NF-kB signaling pathway in HUVECs, Inflammation, 40, 1450, 10.1007/s10753-017-0588-3 · DOI
  37. Zhu, 2018, Inhibitory effects of miR-25 targeting HMGB1 on macrophage secretion of inflammatory cytokines in sepsis, Oncol Lett, 16, 5027, 10.3892/ol.2018.9308 · DOI
  38. Sun, 2014, Systemic delivery of microRNA-181b inhibits nuclear factor-kappaB activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice, Circ Res, 114, 32, 10.1161/CIRCRESAHA.113.302089 · DOI
  39. Armanious, 2011, Constitutive activation of metalloproteinase ADAM10 in mantle cell lymphoma promotes cell growth and activates the TNFalpha/NFkappaB pathway, Blood, 117, 6237, 10.1182/blood-2010-10-313940 · DOI
  40. Musumeci, 2014, ADAM-10 could mediate cleavage of N-cadherin promoting apoptosis in human atherosclerotic lesions leading to vulnerable plaque: a morphological and immunohistochemical study, Acta Histochem, 116, 1148, 10.1016/j.acthis.2014.06.002 · DOI
  41. Jercan, 2012, Immunoexpression of alpha-SMA and CD68 in native kidney biopsies, Rom J Morphol Embryol, 53, 1037
  42. Wang, 2007, RNAi-mediated inhibition of COL1A1 and COL3A1 in human skin fibroblasts, Exp Dermatol, 16, 611, 10.1111/j.1600-0625.2007.00574.x · DOI
  43. Tortorella, 2014, Interleukin-6, interleukin-1beta, and tumor necrosis factor alpha in menstrual effluents as biomarkers of chronic endometritis, Fertil Steril, 101, 242, 10.1016/j.fertnstert.2013.09.041 · DOI

Cited by

Sorted by citations

See all 70

Metadata

Authors
Yao, Y., Sun, W., Sun, Q., Jing, B., Liu, S., Liu, X., Shen, G., Chen, R., & Wang, H.
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2019-10-02
Volume
10
ISSN
1664-3224
DOI
10.3389/fimmu.2019.02205
PMC
PMC6783608
Cited by
70
References
2
Status
Retracted
Update notices
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
National Natural Science Foundation of China (81570424, 81770355)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: RETRACTED: Platelet-Derived Exosomal MicroRNA-25-3p Inhibits Coronary Vascular Endothelial Cell Inflammation Through Adam10 via the NF-κB Signaling Pathway in ApoE−/− Mice. https://app.cochat.ai/papers/10.3389/fimmu.2019.02205
The paper
Yao, Y., Sun, W., Sun, Q., Jing, B., Liu, S., Liu, X., Shen, G., Chen, R., & Wang, H. (2019). RETRACTED: Platelet-Derived Exosomal MicroRNA-25-3p Inhibits Coronary Vascular Endothelial Cell Inflammation Through Adam10 via the NF-κB Signaling Pathway in ApoE−/− Mice. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2019.02205