Effect of ergothioneine on acute lung injury and inflammation in cytokine insufflated rats
Open accessAbstract
Objective The Acute Respiratory Distress Syndrome (ARDS), the most severe form of Acute Lung Injury (ALI), is a highly-fatal, diffuse non-cardiogenic edematous lung disorder. The pathogenesis of ARDS is unknown but lung inflammation and lung oxidative stress are likely contributing factors. Since no specific pharmacologic intervention exists for ARDS, our objective was to determine the effect of treatment with ergothioneine-a safe agent with multiple anti-inflammatory and antioxidant properties on the development of lung injury and inflammation in rats insufflated with cytokines found in lung lavages of ARDS patients.Method Sprague-Dawley rats (3-10/group) were given 15 mg/kg or 150 mg/kg l-ergothioneine intravenously 1h before or 18 h after cytokine (IL-1 and IFNγ) insufflation. Lung injury (lavage LDH levels) and lung inflammation (lavage neutrophil numbers) were measured 24h after cytokine insufflation.Results Ergothioneine pre- and post-treatment generally decreased lung injury and lung inflammation in cytokine insufflated rats.Conclusion Ergothioneine should be considered for additional testing as a potential therapy for treating and preventing ARDS.
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ERG has been found to be an effective antioxidant in cardiovascular diseases, chronic pulmonary diseases, lung inflammatory diseases, and other pathologies.
“ERG has been found to be an effective antioxidant in cardiovascular diseases (Servillo et al. 2017), chronic pulmonary diseases (Rahman 2012), lung inflammatory diseases (Repine and Elkins 2012), and other pathologies.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Repine and Elkins 2012
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
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“from a variety of sources, including metabolite measurements in human subjects(121,122,509), and intervention studies in both animals(505) and cell lines(3,124,506).”
BackgroundErgothioneine, an adaptive antioxidant for the protection of injured tissues? A hypothesis
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- Authors
- Repine, J. E., & Elkins, N. D.
- Affiliations
- University of Colorado Denver (US)
- Corresponding author
- Repine, John E.
- ORCID
- Repine, John E.
- Venue
- Preventive Medicine
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 54
- Pages
- S79-S82
- ISSN
- 0091-7435 (ISSN-L)
- PMC
- PMC3355229
- OpenAlex
- W2073432030
- Cited by
- 43
- References
- 25
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 7 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Preventive Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL045582, R25HL108823)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Keywords
- ergothioneine, acute lung injury, acute respiratory distress syndrome, lung inflammation, oxidative stress, interleukin-1, interferon-gamma, neutrophils, antioxidant therapy, ARDS treatment
- MeSH terms
- Animals, Antioxidants, Ergothioneine, Male, Pneumonia, Respiratory Distress Syndrome, Cytokines, Rats, Sprague-Dawley, Rats
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