Ergothioneine, an adaptive antioxidant for the protection of injured tissues? A hypothesis
Abstract
Ergothioneine (ET) is a diet-derived, thiolated derivative of histidine with antioxidant properties. Although ET is produced only by certain fungi and bacteria, it can be found at high concentrations in certain human and animal tissues and is absorbed through a specific, high affinity transporter (OCTN1). In liver, heart, joint and intestinal injury, elevated ET concentrations have been observed in injured tissues. The physiological role of ET remains unclear. We thus review current literature to generate a specific hypothesis: that the accumulation of ET in vivo is an adaptive mechanism, involving the regulated uptake and concentration of an exogenous natural compound to minimize oxidative damage.
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ERG ameliorates oxidative stress at the sites of injuries and has been classified as an "adaptive antioxidant" because it does not interfere with the physiological function of ROS.
“ERG ameliorates oxidative stress at the sites of injuries and has been classified as an “adaptive antioxidant” because it does not interfere with the physiological function of ROS (Halliwell et al. 2016).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Halliwell et al. 2016
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
The biology of ergothioneine, an antioxidant nutraceutical
Borodina, I., Kenny, L. C., McCarthy, C. M., Paramasivan, K., Pretorius, E., Roberts, T. J., van der Hoek, S. A., & Kell, D. B. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422419000301 · Cited by 296 · see citing works
Feng, L., Cheah, I. K.-M., Ng, M. M.-X., Li, J., Chan, S. M., Lim, S. L., Mahendran, R., Kua, E.-H., & Halliwell, B. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-180959 · Cited by 112 · see citing works
Self-citationHalliwell, B. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.08.098 · Cited by 87 · see citing works
Self-citationErgothioneine Antioxidant Function: From Chemistry to Cardiovascular Therapeutic Potential
Servillo, L., D'Onofrio, N., & Balestrieri, M. L. (2017) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000464 · Cited by 81 · see citing works
Reflections of an aging free radical
Halliwell, B. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.10.010 · Cited by 75 · see citing works
Self-citationMicronutrients and Bioactive Compounds in Mushrooms: A Recipe for Healthy Aging?
Beelman, R. B., Kalaras, M. D., & Richie, J. P. (2019) · Nutrition Today · doi:10.1097/nt.0000000000000315 · Cited by 54 · see citing works
Specificity of the ergothioneine transporter natively expressed in HeLa cells
Tucker, R. A. J., Cheah, I. K., & Halliwell, B. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.122 · Cited by 38 · see citing works
Self-citation
- Authors
- Halliwell, B., Cheah, I. K., & Drum, C. L.
- Affiliations
- National University of Singapore (SG)
- Corresponding author
- Halliwell, Barry
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 470
- Issue
- 2
- Pages
- 245-250
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2226372355
- Cited by
- 123
- References
- 102
- Citations by year
- 2026: 15 · 2025: 10 · 2024: 9 · 2023: 12 · 2022: 20 · 2021: 11 · 2020: 11 · 2019: 11 · 2018: 11 · 2017: 10 · 2016: 3
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Funders
- National Medical Research Council (NMRC/1264/2010/082/12)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- ergothioneine, antioxidants, oxidative damage, tissue damage, histidine derivatives, thiols, dietary uptake, liver injury, cardiac injury, joint injuries, intestinal injury, adaptive mechanisms
- MeSH terms
- Adaptation, Physiological, Animals, Antioxidants, Ergothioneine, Humans, Inflammation, Organ Specificity, Tissue Distribution, Cytoprotection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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