The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The safety of green tea and green tea extract consumption in adults – Results of a systematic review
Open accessAbstract
A systematic review of published toxicology and human intervention studies was performed to characterize potential hazards associated with consumption of green tea and its preparations. A review of toxicological evidence from laboratory studies revealed the liver as the target organ and hepatotoxicity as the critical effect, which was strongly associated with certain dosing conditions (e.g. bolus dose via gavage, fasting), and positively correlated with total catechin and epigallocatechingallate (EGCG) content. A review of adverse event (AE) data from 159 human intervention studies yielded findings consistent with toxicological evidence in that a limited range of concentrated, catechin-rich green tea preparations resulted in hepatic AEs in a dose-dependent manner when ingested in large bolus doses, but not when consumed as brewed tea or extracts in beverages or as part of food. Toxico- and pharmacokinetic evidence further suggests internal dose of catechins is a key determinant in the occurrence and severity of hepatotoxicity. A safe intake level of 338 mg EGCG/day for adults was derived from toxicological and human safety data for tea preparations ingested as a solid bolus dose. An Observed Safe Level (OSL) of 704 mg EGCG/day might be considered for tea preparations in beverage form based on human AE data.
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Chow, H.-H. S., Hakim, I. A., Vining, D. R., Crowell, J. A., Ranger-Moore, J., Chew, W. M., Celaya, C. A., Rodney, S. R., Hara, Y., & Alberts, D. S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2549 · Cited by 400
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Effects of Catechin Enriched Green Tea on Body Composition
Wang, H., Wen, Y., Du, Y., Yan, X., Guo, H., Rycroft, J. A., Boon, N., Kovacs, E. M. R., & Mela, D. J. (2010) · Obesity · doi:10.1038/oby.2009.256 · Cited by 185
Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics
García-Cortés, M., Robles-Díaz, M., Ortega-Alonso, A., Medina-Caliz, I., & Andrade, R. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040537 · Cited by 179
Toxicity of green tea extracts and their constituents in rat hepatocytes in primary culture
Schmidt, M., Schmitz, H.-J., Baumgart, A., Guédon, D., Netsch, M. I., Kreuter, M.-H., Schmidlin, C. B., & Schrenk, D. (2005) · Food and Chemical Toxicology · doi:10.1016/j.fct.2004.11.001 · Cited by 158
Naumovski, N., Blades, B., & Roach, P. (2015) · Antioxidants · doi:10.3390/antiox4020373 · Cited by 108
Physiologically based pharmacokinetic modeling of tea catechin mixture in rats and humans
Law, F. C. P., Yao, M., Bi, H., & Lam, S. (2017) · Pharmacology Research & Perspectives · doi:10.1002/prp2.305 · Cited by 23
Cited by
Madeo, F., Carmona-Gutierrez, D., Hofer, S. J., & Kroemer, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.018 · Cited by 630
Klingel, T., Kremer, J. I., Gottstein, V., Rajcic de Rezende, T., Schwarz, S., & Lachenmeier, D. W. (2020) · Foods · doi:10.3390/foods9050665 · Cited by 264
United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts
Oketch-Rabah, H. A., Roe, A. L., Rider, C. V., Bonkovsky, H. L., Giancaspro, G. I., Navarro, V., Paine, M. F., Betz, J. M., Marles, R. J., Casper, S., et al. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2020.02.008 · Cited by 168
Goodlett, C. R., Stringer, M., LaCombe, J., Patel, R., Wallace, J. M., & Roper, R. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-67133-z · Cited by 43
Baba, Y., Inagaki, S., Nakagawa, S., Kobayashi, M., Kaneko, T., & Takihara, T. (2021) · Nutrients · doi:10.3390/nu13051700 · Cited by 33
Metadata
- Authors
- Hu, J., Webster, D., Cao, J., & Shao, A.
- Venue
- Regulatory Toxicology and Pharmacology
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 95
- Pages
- 412-433
- ISSN
- 0273-2300 (ISSN-L)
- OpenAlex
- W2793866498
- Cited by
- 405
- References
- 7
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hu, J., Webster, D., Cao, J., & Shao, A. (2018). The safety of green tea and green tea extract consumption in adults – Results of a systematic review. Regulatory Toxicology and Pharmacology. https://doi.org/10.1016/j.yrtph.2018.03.019
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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