A paradigm shift in neurobiology: peripheral nerves deliver cellular material and control development
Open accessAbstract
Living beings are extremely complex. Multiple structures, especially evolutionarily young ones, develop or take their final shape during late stages of embryonic development, when the body of an embryo is large and comprised of a huge number of cells. Yet, these late structures frequently need cellular sources from other locations and, sometimes, developmental stages. During recent years it became obvious that nerves provide a perfect solution for transporting and hosting multipotent cells that are later recruited to become new cellular sources in the innervated organs. Moreover, the role of nerves and nerve-dwelling cells in morphogenesis and regeneration seems to be much broader than was previously appreciated in invertebrate and vertebrate animals. In a broader view, nerves can provide material for morphological plasticity and evolutional diversity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The spectrum of functions performed by nervous systems is broader than communication and information exchange between the central nervous system, the rest of the body and the environment.
“However, the spectrum of functions performed by nervous systems is much broader.”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [113]
Non-canonical functions of nervous systems may include roles in regeneration, development of innervated tissues, tissue homeostasis, and bidirectional communication with the commensal microbiota.
“Non-canonical functions may include a role in regeneration, development of innervated tissues, and tissue homeostasis [113,114] as well as bidirectional communication with the commensal microbiota [115–120].”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [113]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Neural Crest and the Origin of Vertebrates: A New Head
Gans, C., & Northcutt, R. G. (1983) · Science · doi:10.1126/science.220.4594.268 · Cited by 1,053 · see citing works
Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate
Kumar, A., Godwin, J. W., Gates, P. B., Garza-Garcı́a, A., & Brockes, J. P. (2007) · Science · doi:10.1126/science.1147710 · Cited by 487 · see citing works
Zhao, H., Feng, J., Seidel, K., Shi, S., Klein, O. D., Sharpe, P. T., & Chai, Y. (2014) · Cell stem cell · doi:10.1016/j.stem.2013.12.013 · Cited by 464 · see citing works
Brownell, I., Guevara, E., Bai, C. B., Loomis, C. A., & Joyner, A. L. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.02.021 · Cited by 453 · see citing works
Dual origin of mesenchymal stem cells contributing to organ growth and repair
Feng, J., Mantesso, A., Bari, C. D., Nishiyama, A., & Sharpe, P. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015449108 · Cited by 412 · see citing works
Parasympathetic neurons originate from nerve-associated peripheral glial progenitors
Dyachuk, V. A., Furlan, A., Shahidi, M. K., Giovenco, M., Kaukua, N., Konstantinidou, C., Pachnis, V., Memic, F., Marklund, U., Müller, T. H., et al. (2014) · Science · doi:10.1126/science.1253281 · Cited by 230 · see citing works
Self-citationLi, W., Kohara, H., Uchida, Y., James, J. M., Soneji, K., Cronshaw, D. G., Zou, Y.-R., Nagasawa, T., & Mukouyama, Y. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.01.009 · Cited by 165 · see citing works
[Pioneer neurons: a basis or bottleneck of diversity of nervous systems of Lophotrochozoa?].
Ee, V., & Ivashkin, E. G. (2011) · PubMed · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Back to the Basics: Cnidarians Start to Fire
Bosch, T. C. G., Klimovich, A., Domazet-Lošo, T., Gründer, S., Holstein, T. W., Jékely, G., Miller, D. J., Murillo-Rincon, A. P., Rentzsch, F., Richards, G. S., et al. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2016.11.005 · Cited by 144 · see citing works
The nervous system orchestrates and integrates craniofacial development: a review
Adameyko, I., & Fried, K. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00049 · Cited by 69 · see citing works
- Authors
- Ivashkin, E., Voronezhskaya, E. E., & Adameyko, I.
- Affiliations
- Research Center of Neurology (RU)
- Russian Academy of Sciences (RU)
- Karolinska Institutet (SE)
- Corresponding author
- Adameyko, Igor
- Venue
- Zoology
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 117
- Issue
- 5
- Pages
- 293-294
- ISSN
- 0944-2006 (ISSN-L)
- OpenAlex
- W1983735967
- Cited by
- 8
- References
- 8
- Citations by year
- 2026: 1 · 2018: 1 · 2016: 4 · 2015: 2
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Zoology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Bertil Hållsten Research Foundation, Swedish Research Council and StratRegen SFO
- Russian Foundation for Basic Research (14-04-32027, 12-04-01510)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- peripheral nerves, cell migration, morphogenesis, organogenesis, regeneration, morphological plasticity, evolutionary diversity, multipotent stem cells
- MeSH terms
- Animals, Cell Movement, Biological Evolution, Morphogenesis, Neural Crest, Neurobiology, Peripheral Nerves, Vertebrates, Multipotent Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
