Effect of short- and long-duration spaceflight on QTc intervals in healthy astronauts

D’Aunno, Dominick S.; Dougherty, Anne H.; DeBlock, Heidi F.; Meck, Janice V.

doi:10.1016/s0002-9149(02)03259-9

Cited by 88Spaceflight effects on biologyCardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic Control

Effect of short- and long-duration spaceflight on QTc intervals in healthy astronauts

D’Aunno, Dominick S., Dougherty, Anne H., DeBlock, Heidi F., Meck, Janice V.·2003·The American Journal of Cardiology

DOI 10.1016/s0002-9149(02)03259-9

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Some drugs used during spaceflight may cause a delay in the QT interval and thus could increase the risk of arrhythmia.
“It is important to consider this because some drugs used during spaceflight may cause a delay in the QT interval and thus could increase the risk of arrhythmia114.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [114]
The paper’s concluding passage says that long-duration spaceflight prolongs QTc, may increase susceptibility to arrhythmia, and warrants caution with medications that prolong the QT interval. It does not establish that particular QT-prolonging drugs are used during spaceflight or that their use caused the observed prolongation. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Cardiac arrhythmia is a problem that has been reported in long-duration spaceflight, especially related to a QT prolongation observed on electrocardiograms.
“Cardiac arrhythmia is a problem that has been reported in long-duration spaceflight, especially related to a QT prolongation observed on electrocardiograms110,114.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [114]

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Long-Duration Space Flight Provokes Pathologic Q-Tc Interval Prolongation
D’Aunno, D. S., DOUGHERTY, A. H., DeBlock, H. F., & Meck, J. V. (2002) · NASA Technical Reports Server (NASA)
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Short-duration spaceflight does not prolong QTc intervals in male astronauts
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An Episode of Ventricular Tachycardia During Long-Duration Spaceflight
Fritsch-Yelle, J. M., Leuenberger, U. A., D’Aunno, D. S., Rossum, A. C., Brown, T. E., Wood, M. L., Josephson, M. E., & Goldberger, A. L. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00179-9 · Cited by 97 · see citing works
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Detection and Prevention of Cardiac Arrhythmias During Space Flight
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Risk of Cardiac Rhythm Problems During Spaceflight
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Authors: D’Aunno, D. S., Dougherty, A. H., DeBlock, H. F., & Meck, J. V.
Affiliations: National Space Biomedical Research Institute (US)
The University of Texas Health Science Center at Houston (US)
Albany Medical College (US)
National Aeronautics and Space Administration (US)
Corresponding author: Meck, Janice V.
Venue: The American Journal of Cardiology
Publisher: Elsevier BV
Published: 2003-02
Volume: 91
Issue: 4
Pages: 494-497
ISSN: 0002-9149 (ISSN-L)
DOI: 10.1016/s0002-9149(02)03259-9
OpenAlex: W2148003491
Cited by: 88
References: 7
Citations by year: 2026: 5 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 3 · 2019: 10 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 4
FWCI: 2.01
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The American Journal of Cardiology (publishedVersion)
PubMed (publishedVersion)
Funders: Johnson Space Center
Topics: Health Sciences › Medicine › Physiology › Spaceflight effects on biology
Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords: spaceflight, QTc interval, cardiac repolarization, long-duration spaceflight, short-duration spaceflight, astronauts, cardiovascular autonomic regulation, cardiac arrhythmias, ventricular tachycardia, microgravity, heart rate variability, heart rate variability spectral analysis, heart rate variability time domain analysis
MeSH terms: Adult, Calcium, Female, Heart Conduction System, Humans, Long QT Syndrome, Magnesium, Male, Middle Aged, Rest, Retrospective Studies, Risk Factors, Sodium, Space Flight, Time Factors, Electrocardiography, Ambulatory, Single-Blind Method, Supine Position, Astronauts

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