Cited by 50Spaceflight effects on biologySpinal Cord Injury ResearchSpace Exploration and Technology

Challenges, concerns and common problems: physiological consequences of spinal cord injury and microgravity

Scott, J M, Warburton, D E R, Williams, D, Whelan, S, Krassioukov, A·2011·Spinal Cord

Abstract

Introduction Similarities between the clinical presentation of individuals living with spinal cord injury (SCI) and astronauts are remarkable, and may be of great interest to clinicians and scientists alike.Objectives The primary purpose of this review is to outline the manner in which cardiovascular, musculoskeletal, renal, immune and sensory motor systems are affected by microgravity and SCI.Methods A comprehensive review of the literature was conducted (using PubMed) to evaluate the hallmark symptoms seen after spaceflight and SCI. This literature was then examined critically to determine symptoms common to both populations.Results Both SCI and prolonged microgravity exposure are associated with marked deteriorations in various physiological functions. Atrophy in muscle and bone, cardiovascular disturbances, and alterations in renal, immune and sensory motor systems are conditions commonly observed not only in individuals with SCI, but also in those who experience prolonged gravity unloading.Conclusion The preponderance of data indicates that similar physiological changes occur in both SCI and prolonged space flight. These findings have important implications for future research in SCI and prolonged space flight.

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Crossref · 10.1038/sc.2010.53

Cites

126 of 126 references verified0 citation errors · 0 not checkable

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  • Previous studies demonstrated that alterations following spinal cord injury and exposure to microgravity are remarkably similar.

    “Furthermore, previous studies demonstrated that the alterations that occur following spinal cord injury and exposure to microgravity are remarkably similar [22].”

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Authors
Scott, J. M., Warburton, D. E. R., Williams, D., Whelan, S., & Krassioukov, A.
Affiliations
  • University of British Columbia (CA)
  • McMaster University (CA)
  • Vancouver Coastal Health (CA)
Corresponding author
Scott, J M
Venue
Spinal Cord
Published
2010-05-25
Volume
49
Issue
1
Pages
4-16
ISSN
  • 1362-4393 (ISSN-L)
  • 1476-5624
OpenAlex
W2007973625
Cited by
50
References
127
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 4 · 2013: 2 · 2012: 2
FWCI
1.08
Type
journal article
Language
en
Open access
closed
Locations
  • Spinal Cord (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Christopher and Dana Reeve Foundation
  • Heart and Stroke Foundation of Canada
  • Michael Smith Health Research BC
  • International Collaboration on Repair Discoveries
  • Canadian Institutes of Health Research
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
  • Physical Sciences › Engineering › Aerospace Engineering › Space Exploration and Technology
Keywords
spinal cord injury, microgravity, spaceflight, muscle atrophy, bone atrophy, cardiovascular deconditioning, renal dysfunction, immune system alterations, sensory-motor dysfunction, astronaut physiology
MeSH terms
Humans, Spinal Cord Injuries, Weightlessness

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