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Cited by 122Acute Myocardial Infarction ResearchCircadian rhythm and melatoninHeart rate and cardiovascular health

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Circadian Variation in the Onset of Unstable Angina and Non-Q-Wave Acute Myocardial Infarction (The TIMI III Registry and TIMI IIIB)

Cannon, Christopher P., McCabe, Carolyn H., Stone, Peter H., Schactman, Mark, Thompson, Bruce, Theroux, Pierre, Gibson, Robert S., Feldman, Ted, Kleiman, Neal S., Tofler, Geoffrey H., Muller, James E., Chaitman, Bernard R., Braunwald, Eugene·1997·The American Journal of Cardiology
DOI 10.1016/s0002-9149(97)00743-1
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Abstract

Circadian variation has been demonstrated in several types of acute cardiovascular disease, including acute myocardial infarction (AMI), sudden cardiac death, silent ambulatory ischemia, and thrombotic stroke. In contrast, no diurnal variation was observed in 1 study of non-Q-wave AMI, and limited data are available for unstable angina. To assess whether circadian variation is present in unstable angina and non-Q-wave AMI, we examined the time of onset of ischemic pain in 7,731 patients who were prospectively identified in the Thrombolysis in Myocardial Ischemia (TIMI) III Registry, 3,318 of whom were enrolled in the prospective study, and in 1,473 patients enrolled in the TIMI IIIB trial. A circadian variation in the onset of pain was observed, with an increase in the number of patients experiencing the onset of pain in the morning hours between 6 A.M. and 12 noon (p <0.001). This circadian variation was observed both in patients with unstable angina and in those with evolving non-Q-wave AMI. A similar circadian pattern was observed in all subgroups tested. These findings were confirmed in the TIMI IIIB trial and complement previous studies suggesting that circadian variation exists in the onset of the full spectrum of myocardial ischemic syndromes.

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Crossref · 10.1016/s0002-9149(97)00743-1

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Research works printed but not linked: 1

  1. Borzak, 1994, Prior aspirin use in unstable coronary disease: myth of aspirin resistance? (abstr), Circulation, 90, I, 232

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Metadata

Authors
Cannon, C. P., McCabe, C. H., Stone, P. H., Schactman, M., Thompson, B., Theroux, P., Gibson, R. S., Feldman, T., Kleiman, N. S., Tofler, G. H., Muller, J. E., Chaitman, B. R., & Braunwald, E.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Cannon, Christopher P.
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1997-02
Volume
79
Issue
3
Pages
253-258
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/s0002-9149(97)00743-1
OpenAlex
W1979609806
Cited by
122
References
29
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 2 · 2017: 8 · 2016: 5 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 5
FWCI
4.28
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hl042311-03, 5r01hl042428-04, 1r01hl042419-01)
  • National Heart, Lung, and Blood Institute (R01 HL 42419, R01-HL42311, R01-HL-42428)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
Keywords
circadian variation, unstable angina, diurnal variation, myocardial ischemia, thrombolysis
MeSH terms
Aged, Angina, Unstable, Circadian Rhythm, Electrocardiography, Female, Humans, Male, Middle Aged, Myocardial Infarction, Prospective Studies, Registries, Thrombolytic Therapy

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