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Cited by 1,339Cardiac Valve Diseases and TreatmentsCardiovascular Function and Risk FactorsCardiac Imaging and Diagnostics

Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study)

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Singh, Jagmeet P, Evans, Jane C, Levy, Daniel, Larson, Martin G, Freed, Lisa A, Fuller, Deborah L, Lehman, Birgitta, Benjamin, Emelia J·1999·The American Journal of Cardiology
DOI 10.1016/s0002-9149(98)01064-9
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Abstract

Little information is available on the prevalence and determinants of valvular regurgitation in the general population. This study sought to assess the prevalence and clinical determinants of mitral (MR), tricuspid (TR), and aortic (AR) regurgitation in a population-based cohort. Color Doppler echocardiography was performed in 1,696 men and 1,893 women (aged 54 +/- 10 years) attending a routine examination at the Framingham Study. After excluding technically poor echocardiograms, MR, TR, and AR were qualitatively graded from trace to severe. Multiple logistic regression analysis was used to examine the association of clinical variables with MR and TR (more than or equal to mild severity) and AR (more than or equal to trace severity). MR and TR of more than or equal to mild severity was seen in 19.0% and 14.8% of men and 19.1% and 18.4% of women, respectively, and AR of more than or equal to trace severity in 13.0% of men and 8.5% of women. The clinical determinants of MR were age (odds ratio [OR] 1.3/9.9 years, 95% confidence interval [CI] 1.2 to 1.5), hypertension (OR 1.6; 95% CI 1.2 to 2.0), and body mass index (OR 0.8/4.3 kg/m2; 95% CI 0.7 to 0.9). The determinants of TR were age (OR 1.5/9.9 years; 95% CI 1.3 to 1.7), body mass index (OR 0.7/4.3 kg/m2; 95% CI 0.6 to 0.8), and female gender (OR 1.2; 95% CI 1.0 to 1.6). The determinants of AR were age (OR 2.3/9.9 years; 95% CI 2.0 to 2.7) and male gender (OR 1.6; 95% CI 1.2 to 2.1). A substantial proportion of healthy men and women had detectable valvular regurgitation by color Doppler echocardiography. These data provide population-based estimates for comparison with patients taking anorectic drugs.

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Crossref · 10.1016/s0002-9149(98)01064-9

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  • A widely cited paper showed a lower prevalence of valvular regurgitation in obese than in normal-weight subjects.

    “Somewhat counterintuitively, a widely cited paper that evaluated the frequency of valvular abnormalities in a relatively large cohort of subjects undergoing echocardiography showed a lower prevalence of valvular regurgitation in obese than in normal-weight subjects (323).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [323]

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Authors
Singh, J. P., Evans, J. C., Levy, D., Larson, M. G., Freed, L. A., Fuller, D. L., Lehman, B., & Benjamin, E. J.
Affiliations
Boston University (US)
Corresponding author
Benjamin, Emelia J
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1999-03
Volume
83
Issue
6
Pages
897-902
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/s0002-9149(98)01064-9
OpenAlex
W2094373590
Cited by
1,339
References
26
Citations by year
2026: 50 · 2025: 97 · 2024: 113 · 2023: 102 · 2022: 92 · 2021: 85 · 2020: 84 · 2019: 77 · 2018: 66 · 2017: 54 · 2016: 39 · 2015: 42 · 2014: 40 · 2013: 45 · 2012: 52
FWCI
7.03
Type
journal article
Language
en
Open access
Licence
Locations
  • The American Journal of Cardiology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01hc038038-022)
  • National Heart, Lung, and Blood Institute (N01-HC-38038)
  • National Institute of Neurological Disorders and Stroke (2-RO1-NS-17950-11, R01NS017950)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords
mitral regurgitation, tricuspid regurgitation, aortic regurgitation, valvular regurgitation, prevalence, risk factors, hypertension, body mass index, age, sex differences, color Doppler echocardiography, Framingham Heart Study, middle-aged adults, population-based estimates, aortic stenosis, aortic valve
MeSH terms
Adult, Age Factors, Aged, Aged, 80 and over, Aortic Valve Insufficiency, Female, Humans, Hypertension, Male, Middle Aged, Mitral Valve Insufficiency, Risk Factors, Tricuspid Valve Insufficiency, Prevalence, Multivariate Analysis, Logistic Models, Echocardiography, Doppler, Color

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