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Cited by 49Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityObesity, Physical Activity, Diet

Patterns of body fat deposition in youth and their relation to left ventricular markers of adverse cardiovascular prognosis

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Mensah, George A, Treiber, Frank A, Kapuku, Gaston K, Davis, Harry, Barnes, Vernon A, Strong, William B·1999·The American Journal of Cardiology
DOI 10.1016/s0002-9149(99)00383-5PMC PMC3289101
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Abstract

The patterns of body fat deposition in healthy youth and their relation to future development of cardiovascular disease remain incompletely understood. To further evaluate these patterns, we measured indirect indexes of central and general fat deposition in healthy adolescents (mean age 15.4+/-2.3 years) with family histories of hypertension. We examined the relation between these indexes and echocardiographic markers of adverse prognosis as well as the effect of gender and ethnicity. All 225 subjects (64% black and 48% female) had > or =1 biologic parent and 1 grandparent with hypertension. Skinfold thicknesses, waist-to-hip girth ratio, Quetelet index, Ponderal index, conicity, and Z score weight - Z score height were measured. Left ventricular (LV) mass, indexed LV mass, relative wall thickness (RWT), and midwall fractional shortening (MFS) were determined using echocardiography. In both black and white subjects, the adiposity indexes were significantly correlated with posterior wall thickness, total LV mass, and indexed LV mass (p <0.05 for all). Additionally, in black subjects, central adiposity was inversely related to MFS and directly related to RWT and septal thickness. General adiposity independently predicted indexed and nonindexed LV mass, whereas central adiposity predicted MFS and RWT. Compared with subjects with normal LV geometry, those with abnormal geometry were heavier and fatter based on every index of obesity (p <0.03 for all). Thus, indexes of fat deposition are significantly correlated with LV markers of adverse prognosis in healthy youth.

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  • Many published studies have concluded that obesity is independently associated with LV hypertrophy.

    “Many published studies have concluded that obesity is independently associated with LV hypertrophy (22, 28, 63, 72, 116, 235, 242, 266, 279, 284, 377).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [235]

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  1. [7]Wright R, Heymsfield S. Nutrition Assessment. New York: Blackwell Scientific Publishing, Inc.; 1984. [Google Scholar]

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Authors
Mensah, G. A., Treiber, F. A., Kapuku, G. K., Davis, H., Barnes, V. A., & Strong, W. B.
Affiliations
Augusta University (US)
Corresponding author
Treiber, Frank A
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1999-09
Volume
84
Issue
5
Pages
583-588
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/s0002-9149(99)00383-5
PMC
PMC3289101
OpenAlex
W2031277757
Cited by
49
References
31
Citations by year
2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2016: 1 · 2015: 4 · 2013: 2 · 2012: 2
FWCI
2.42
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL041781, HL 35073, HL-41781, R01HL035073)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
fat deposition, abdominal obesity, general adiposity, adolescents, left ventricular mass, left ventricular geometry, relative wall thickness, midwall fractional shortening, cardiovascular risk, family history of hypertension, skinfold thickness, waist-to-hip ratio, obesity indices, ethnic differences, sex differences
MeSH terms
Adolescent, Adult, Anthropometry, Body Composition, Cardiac Volume, Echocardiography, Female, Hemodynamics, Humans, Hypertension, Longitudinal Studies, Male, Obesity, Prognosis, Risk Factors, Skinfold Thickness, Somatotypes, Body Mass Index, Hypertrophy, Left Ventricular, Genetic Predisposition to Disease, Ventricular Remodeling

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