The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Milk Thistle (Silybum marianum) for the Therapy of Liver Disease
Abstract
Silymarin, derived from the milk thistle plant, Silybum marianum, has been used for centuries as a natural remedy for diseases of the liver and biliary tract. As interest in alternative therapy has emerged in the United States, gastroenterologists have encountered increasing numbers of patients taking silymarin with little understanding of its purported properties. Silymarin and its active constituent, silybin, have been reported to work as antioxidants scavenging free radicals and inhibiting lipid peroxidation. Studies also suggest that they protect against genomic injury, increase hepatocyte protein synthesis, decrease the activity of tumor promoters, stabilize mast cells, chelate iron, and slow calcium metabolism. In this article we review silymarin's history, pharmacology, and properties, and the clinical trials pertaining to patients with acute and chronic liver disease.
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Cites
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Cited by
Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review
Gillessen, A., & Schmidt, H. H.-J. (2020) · Advances in Therapy · doi:10.1007/s12325-020-01251-y · Cited by 490
A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients
Flaig, T. W., Gustafson, D. L., Su, L.-J., Zirrolli, J. A., Crighton, F., Harrison, G. S., Pierson, A. S., Agarwal, R., & Glodé, L. M. (2007) · Investigational New Drugs · doi:10.1007/s10637-006-9019-2 · Cited by 315
Dietary Antioxidant Compounds and Liver Health
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A randomized trial of silymarin for the treatment of nonalcoholic steatohepatitis
Wah Kheong, C., Nik Mustapha, N. R., & Mahadeva, S. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.04.016 · Cited by 264
Analysis of the active components of silymarin
Kvasnička, F., Bı́ba, B., Ševčı́k, R., Voldřich, M., & Krátká, J. (2003) · Journal of Chromatography A · doi:10.1016/s0021-9673(02)01971-4 · Cited by 262
Metadata
- Authors
- Flora, K.
- Venue
- The American Journal of Gastroenterology
- Published
- 1998-02
- Volume
- 93
- Issue
- 2
- Pages
- 139-143
- ISSN
- 0002-9270 (ISSN-L)
- OpenAlex
- W2003227142
- Cited by
- 746
- References
- 17
- FWCI
- 19.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Milk Thistle (Silybum marianum) for the Therapy of Liver Disease. https://app.cochat.ai/papers/10.1016/s0002-9270(97)00082-8
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- Flora, K. (1998). Milk Thistle (Silybum marianum) for the Therapy of Liver Disease. The American Journal of Gastroenterology. https://doi.org/10.1016/s0002-9270(97)00082-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
