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Cited by 1,562Atrial Fibrillation Management and OutcomesCardiac Health and Mental HealthAcute Ischemic Stroke Management

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

A population-based study of the long-term risks associated with atrial fibrillation: 20-year follow-up of the Renfrew/Paisley study

Stewart, Simon, Hart, Carole L, Hole, David J, McMurray, John J.V·2002·The American Journal of Medicine
DOI 10.1016/s0002-9343(02)01236-6
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Abstract

Purpose To describe the effect of atrial fibrillation on long-term morbidity and mortality.Subjects and methods The Renfrew/Paisley Study surveyed 7052 men and 8354 women aged 45-64 years between 1972 and 1976. All hospitalizations and deaths occurring during the subsequent 20 years were analyzed by the presence or absence of atrial fibrillation at baseline. Lone atrial fibrillation was defined in the absence of other cardiovascular signs or symptoms. Cox proportional hazards models were used to adjust for age and cardiovascular conditions.Results After 20 years, 42 (89%) of the 47 women with atrial fibrillation had a cardiovascular event (death or hospitalization), compared with 2276 (27%) of the 8307 women without this arrhythmia. Among men, 35 (66%) of 53 with atrial fibrillation had an event, compared with 3151 (45%) of 6999 without atrial fibrillation. In women, atrial fibrillation was an independent predictor of cardiovascular events (rate ratio [RR] = 3.0; 95% confidence interval [CI]: 2.1-4.2), fatal or nonfatal strokes (RR = 3.2; 95% CI: 1.0-5.0), and heart failure (RR = 3.4; 95% CI: 1.9-6.2). The rate ratios among men were 1.8 (95% CI: 1.3-2.5) for cardiovascular events, 2.5 (95% CI: 1.3-4.8) for strokes, and 3.4 (95% CI: 1.7-6.8) for heart failure. Atrial fibrillation was an independent predictor of all-cause mortality in women (RR = 2.2; 95% CI: 1.5-3.2) and men (RR = 1.5; 95% CI: 1.2-2.2). However, lone atrial fibrillation (which occurred in 15 subjects) was not associated with a statistically significant increase in either cardiovascular events (RR = 1.5; 95% CI: 0.6-3.6) or mortality (RR = 1.8; 95% CI: 0.9-3.8).Conclusions Atrial fibrillation is associated with an increased long-term risk of stroke, heart failure, and all-cause mortality, especially in women.

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Research works printed but not linked: 2

  1. 1965, Definition and classification of chronic bronchitis for epidemiological purposes, Lancet, i, 775
  2. Clarke, 1994, Evidence of inadequate investigation and treatment of patients with heart failure, Br Heart J, 71, 584, 10.1136/hrt.71.6.584 · DOI

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Metadata

Authors
Stewart, S., Hart, C. L., Hole, D. J., & McMurray, J. J. V.
Affiliations
  • University of South Australia (AU)
  • University of Glasgow (GB)
Corresponding author
McMurray, John J.V
ORCID
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
2002-10
Volume
113
Issue
5
Pages
359-364
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/s0002-9343(02)01236-6
OpenAlex
W1971505725
Cited by
1,562
References
33
Citations by year
2026: 26 · 2025: 34 · 2024: 67 · 2023: 45 · 2022: 64 · 2021: 94 · 2020: 129 · 2019: 88 · 2018: 92 · 2017: 81 · 2016: 100 · 2015: 107 · 2014: 97 · 2013: 85 · 2012: 83
FWCI
7.82
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords
atrial fibrillation, long-term morbidity, cardiovascular mortality, stroke, heart failure, sex differences, lone atrial fibrillation, middle-aged adults, cardiovascular hospitalization, all-cause mortality, cardiovascular risk factors, atrial fibrillation risk factors, atrial fibrillation treatment, atrial fibrillation prevention, atrial fibrillation screening
MeSH terms
Atrial Fibrillation, Cardiovascular Diseases, Female, Follow-Up Studies, Humans, Male, Middle Aged, Risk Factors, Scotland, Time Factors, Cohort Studies, Survival Rate, Proportional Hazards Models, Outcome Assessment, Health Care

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