Cited by 256Heart Failure Treatment and ManagementCardiovascular Function and Risk FactorsCardiovascular Health and Risk Factors

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Risk factors for heart failure in the elderly: a prospective community-based study

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Chen, Ya-Ting, Vaccarino, Viola, Williams, Christianna S, Butler, Javed, Berkman, Lisa F, Krumholz, Harlan M·1999·The American Journal of Medicine

DOI 10.1016/s0002-9343(99)00126-6

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Abstract

PURPOSE: The risk factors for the development of heart failure are not clearly defined, particularly for older adults. We undertook the current investigation to examine the associations of traditional cardiovascular risk factors, comorbidity, and psychosocial factors with the risk of heart failure during 10 years of follow-up in a community-based elderly population. SUBJECTS AND METHODS: We evaluated 1,749 subjects, 65 years of age or older, free of heart failure, myocardial infarction, and angina at baseline, who were participating in the New Haven, Connecticut cohort of the Established Population for Epidemiologic Studies of the Elderly program. Cox proportional hazards regression models were used to determine risk ratios (RR) and 95% confidence intervals (CI). RESULTS: During 13,811 person-years of follow-up, 173 subjects developed incident heart failure, as confirmed by chart review. Five factors were independent predictors of heart failure: male sex (RR = 1.7; CI, 1.3 to 2.4), older age (RR = 1.9; CI, 1.3 to 2.7 for age 75 to 84 years, RR = 3.0; CI, 1.7 to 5.5 for age 85 years and older, compared with < or = 74 years), diabetes (RR = 2.9; CI, 2.0 to 4.3), pulse pressure > or = 70 mm Hg (RR = 2.3; CI, 1.3 to 4.3, compared with <50 mm Hg), and body mass index > or = 28 kg/m2 (RR = 1.6; CI, 1.0 to 2.4, compared with <24 kg/ m2). Myocardial infarction occurred during follow-up in 8% of the cohort and was also an important predictor of heart failure (RR = 21; CI, 15 to 31). CONCLUSIONS: Age and traditional cardiovascular risk factors are associated with the development of heart failure in the elderly. Preventive strategies should focus on the management of diabetes, blood pressure, and weight, in addition to the prevention and management of myocardial infarction.

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Authors: Chen, Y.-T., Vaccarino, V., Williams, C. S., Butler, J., Berkman, L. F., & Krumholz, H. M.
Affiliations: Yale University (US)
Vanderbilt University (US)
Harvard University (US)
Yale New Haven Hospital (US)
Corresponding author: Krumholz, Harlan M
ORCID: Vaccarino, Viola
Butler, Javed
Berkman, Lisa F
Krumholz, Harlan M
Venue: The American Journal of Medicine
Publisher: Elsevier BV
Published: 1999-06
Volume: 106
Issue: 6
Pages: 605-612
ISSN: 0002-9343 (ISSN-L)
DOI: 10.1016/s0002-9343(99)00126-6
OpenAlex: W2041631957
Cited by: 256
References: 42
Citations by year: 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 10 · 2019: 6 · 2018: 5 · 2017: 11 · 2016: 6 · 2015: 12 · 2014: 8 · 2013: 11 · 2012: 13
FWCI: 7.51
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 375 d)
Locations: The American Journal of Medicine (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: Yale University
National Institutes of Health
National Institute on Aging (R01-AG-11042, 1T-32-AG-0-0153)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords: heart failure, older adults, risk factors, cardiovascular risk factors, diabetes mellitus, pulse pressure, body mass index, myocardial infarction, comorbidities, psychosocial factors, sex differences, age, blood pressure, weight
MeSH terms: Aged, Aged, 80 and over, Blood Pressure, Connecticut, Depression, Female, Heart Failure, Humans, Male, Prospective Studies, Risk, Risk Factors, Socioeconomic Factors, Comorbidity, Body Mass Index, Incidence, Prevalence, Multivariate Analysis, Odds Ratio

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Risk factors for heart failure in the elderly: a prospective community-based study

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