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Cited by 239Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and related disorders

The DOI matches its Crossref record; 50 of the 55 references it cites were found in a registry or an index.

Do plasma melatonin concentrations decline with age?

Zeitzer, Jamie M, Daniels, Jessica E, Duffy, Jeanne F, Klerman, Elizabeth B, Shanahan, Theresa L, Dijk, Derk-Jan, Czeisler, Charles A·1999·The American Journal of Medicine
DOI 10.1016/s0002-9343(99)00266-1
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Abstract

Purpose Numerous reports that secretion of the putative sleep-promoting hormone melatonin declines with age have led to suggestions that melatonin replacement therapy be used to treat sleep problems in older patients. We sought to reassess whether the endogenous circadian rhythm of plasma melatonin concentration changes with age in healthy drug-free adults.Methods We analyzed the amplitude of plasma melatonin profiles during a constant routine in 34 healthy drug-free older subjects (20 women and 14 men, aged 65 to 81 years) and compared them with 98 healthy drug-free young men (aged 18 to 30 years).Results We could detect no significant difference between a healthy and drug-free group of older men and women as compared to one of young men in the endogenous circadian amplitude of the plasma melatonin rhythm, as described by mean 24-hour average melatonin concentration (70 pmol/liter vs 73 pmol/liter, P = 0.97), or the duration (9.3 hours vs 9.1 hours, P = 0.43), mean (162 pmol/liter vs 161 pmol/liter, P = 0.63), or integrated area (85,800 pmol x min/liter vs 86,700 pmol x min/liter, P = 0.66) of the nocturnal peak of plasma melatonin.Conclusion These results do not support the hypothesis that reduction of plasma melatonin concentration is a general characteristic of healthy aging. Should melatonin replacement therapy or melatonin supplementation prove to be clinically useful, we recommend that an assessment of endogenous melatonin be carried out before such treatment is used in older patients.

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Research works printed but not linked: 7

  1. Carnazzo, 1991, Variations of melatonin incretion in elderly patients affected by cerebral deterioration, Arch Gerontol Geriatr, S2, 123
  2. Claustrat, 1984, A chronobiological study of melatonin and cortisol secretion in depressed subjects, Biol Psychiatry, 19, 1215
  3. Klerman, 1996, Differential changes in amplitude with aging in blind persons, Soc Res Biol Rhythms, 5, 131
  4. Touitou, 1984, Patterns of plasma melatonin with ageing and mental condition, Acta Endocrinol, 106, 145
  5. Pang, 1984, Age and plasma levels of melatonin and N-acetylserotonin in human beings, Neurosci Lett, 16, S25
  6. Hughes, 1998, The role of melatonin and circadian phase in age-related sleep-maintenance insomnia, Sleep, 21, 52
  7. Haimov, 1994, The relationship between urinary 6-sulphatoxymelatonin rhythm and insomnia in old age, Adv Pineal Res, 8, 433

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Metadata

Authors
Zeitzer, J. M., Daniels, J. E., Duffy, J. F., Klerman, E. B., Shanahan, T. L., Dijk, D.-J., & Czeisler, C. A.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Czeisler, Charles A
ORCID
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
1999-11
Volume
107
Issue
5
Pages
432-436
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/s0002-9343(99)00266-1
OpenAlex
W2086521040
Cited by
239
References
55
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 12 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 2 · 2013: 12 · 2012: 3
FWCI
6.06
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Open Research (University of Surrey) (submittedVersion)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Funders
  • National Institute on Aging (R01AG006072, R01-AG-06072, P01AG009975, P01 AG-09975)
  • National Institute of Mental Health (R01 MH45130, R01MH045130)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
plasma melatonin, aging, circadian rhythm, melatonin secretion, melatonin supplementation, healthy older adults
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Circadian Rhythm, Female, Humans, Male, Melatonin, Sleep Wake Disorders

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