Physiological melatonin levels in healthy older people: A systematic review
Abstract
Objective Melatonin plays a major role in maintaining circadian rhythm. Previous studies showed that its secretion pattern and levels could be disturbed in persons with dementia, psychiatric disorders, sleep disorders or with cancer. Also ageing is a factor that could alter melatonin levels, although previous research provides contradicting results. As melatonin supplementation is increasingly applied in older persons as sleep medication, it is important to know if melatonin levels decrease in healthy ageing and/or secretion patterns change. The objective of this study is to determine physiological levels and secretion patterns of melatonin in healthy older people.Methods We performed a systematic review and searched PubMed and Embase for studies published between January 1st 1980 and October 5th 2015 that measured melatonin in healthy persons aged ≥65years.Results Nineteen studies were retrieved. The number of participants ranged from 5 to 60 per study. Melatonin was mostly measured by radioimmunoassay (RIA) and the number of measurements per 24hours varied from 1 to 96. Sixteen studies showed a secretion pattern with a clear peak concentration, mostly at 0200h or 0300h. Maximum concentrations varied greatly from 11.2 to 91.3pgml(-1). Maximum melatonin level in studies with participants mean aged 65-70years was 49.3pgml(-1) and in studies with participants mean aged ≥75years 27.8pgml(-1), p-value <0.001.Conclusion Total melatonin production in 24hours seems not to change in healthy ageing, but the maximal nocturnal peak concentration of melatonin might decline. It is important to take this into account when prescribing melatonin supplementation to older people.
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The average human adult produces between 0.1 mg and 0.9 mg of melatonin daily.
“Since the average human adult produces between 0.1 mg and 0.9 mg of melatonin daily [277], this range is known as physiological doses.”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [277]
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Recent Advances in Nanomaterials Based Optical Sensors for the Detection of Melatonin and Serotonin
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Trough Melatonin Levels Differ between Early and Late Phases of Alzheimer Disease
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Melatonin and age‐related cardiovascular diseases
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β-Arrestin 1 (ARRB1) serves as a molecular marker of the peripheral circadian rhythm
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Melatonin for Insomnia in Medical Inpatients: A Narrative Review
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Melatonin, a potentially effective drug for the treatment of infected bone nonunion
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Predicting circadian phase in community‐dwelling later‐life adults using actigraphy data
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Effect of Auricular Acupressure on Sleep and Pruritus in Patients Undergoing Hemodialysis
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Evaluation of Melatonin and Antioxidant Levels in the Serum of Breast Cancer Patients
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Nanomolar Melatonin Influences Insulin Synthesis and Secretion in Rat Insulinoma INS-1E CellsPreprint
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Exploring melatonin's signalling pathways in the protection against age-related skin deterioration
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- Authors
- Scholtens, R. M., van Munster, B. C., van Kempen, M. F., & de Rooij, S. E. J. A.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Scholtens, Rikie M.
- Venue
- Journal of Psychosomatic Research
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 86
- Pages
- 20-27
- ISSN
- 0022-3999 (ISSN-L)
- OpenAlex
- W2394482042
- Cited by
- 132
- References
- 55
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 16 · 2023: 18 · 2022: 10 · 2021: 18 · 2020: 13 · 2019: 12 · 2018: 9 · 2017: 9 · 2016: 2
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychosomatic Research (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- melatonin, healthy aging, older adults, circadian rhythm, melatonin levels, melatonin supplementation, sleep medication
- MeSH terms
- Aged, Aged, 80 and over, Aging, Circadian Rhythm, Dementia, Female, Health Status, Humans, Male, Melatonin, Sleep, Sleep Wake Disorders, Dietary Supplements, Observational Studies as Topic
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