Bright Light Induction of Strong (Type 0) Resetting of the Human Circadian Pacemaker

Czeisler, Charles A.; Kronauer, Richard E.; Allan, James S.; Duffy, Jeanne F.; Jewett, Megan E.; Brown, Emery N.; Ronda, Joseph M.

doi:10.1126/science.2734611

Cited by 946Circadian rhythm and melatoninSleep and Work-Related FatigueImpact of Light on Environment and Health

Bright Light Induction of Strong (Type 0) Resetting of the Human Circadian Pacemaker

Czeisler, Charles A., Kronauer, Richard E., Allan, James S., Duffy, Jeanne F., Jewett, Megan E., Brown, Emery N., Ronda, Joseph M.·1989·Science

DOI 10.1126/science.2734611

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Abstract

The response of the human circadian pacemaker to light was measured in 45 resetting trials. Each trial consisted of an initial endogenous circadian phase assessment, a three-cycle stimulus which included 5 hours of bright light per cycle, and a final phase assessment. The stimulus induced strong (type 0) resetting, with responses highly dependent on the initial circadian phase of light exposure. The magnitude and direction of the phase shifts were modulated by the timing of exposure to ordinary room light, previously thought to be undetectable by the human pacemaker. The data indicate that the sensitivity of the human circadian pacemaker to light is far greater than previously recognized and have important implications for the therapeutic use of light in the management of disorders of circadian regulation.

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From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [66]

The Geometry of Biological Time
Winfree, A. T. (1980) · doi:10.1007/978-3-662-22492-2 · Cited by 3,613 · see citing works
Light Suppresses Melatonin Secretion in Humans
Lewy, A. J., Wehr, T. A., Goodwin, F. K., Newsome, D. A., & Markey, S. P. (1980) · Science · doi:10.1126/science.7434030 · Cited by 1,913 · see citing works
Circadian Rhythms and the Circadian Organization of Living SystemsPreprint
Pittendrigh, C. S. (1960) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1960.025.01.015 · Cited by 1,397 · see citing works
Human Sleep: Its Duration and Organization Depend on Its Circadian Phase
Czeisler, C. A., Weitzman, E. D., Moore-Ede, M. C., Zimmerman, J. C., & Knauer, R. S. (1980) · Science · doi:10.1126/science.7434029 · Cited by 903 · see citing works
Self-citation
To Honor Fechner and Repeal His Law
Stevens, S. S. (1961) · Science · doi:10.1126/science.133.3446.80 · Cited by 884 · see citing works
Documentation of the Threshold Limit Values and Biological Exposure Indices
Acgih (2001) · Medical Entomology and Zoology · Cited by 848 · see citing works
Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle
Czeisler, C. A., Allan, J. S., Strogatz, S. H., Ronda, J. M., Sánchez, R., Ríos, C. D., Freitag, W. O., Richardson, G. S., & Kronauer, R. E. (1986) · Science · doi:10.1126/science.3726555 · Cited by 770 · see citing works
Antidepressant and Circadian Phase-Shifting Effects of Light
Lewy, A. J., Sack, R. L., Miller, L. S., & Hoban, T. M. (1987) · Science · doi:10.1126/science.3798117 · Cited by 709 · see citing works
Rod outer segment disk shedding in rat retina: relationship to cyclic lighting
LaVail, M. M. (1976) · Science · doi:10.1126/science.982063 · Cited by 689 · see citing works
Free-Running Activity Rhythms in the Rat: Entrainment by Melatonin
Redman, J., Armstrong, S., & Ng, K. T. (1983) · Science · doi:10.1126/science.6823571 · Cited by 551 · see citing works
Putative Melatonin Receptors in a Human Biological Clock
Reppert, S. M., Weaver, D. R., Rivkees, S. A., & Stopa, E. G. (1988) · Science · doi:10.1126/science.2845576 · Cited by 504 · see citing works
Timing of REM Sleep is Coupled to the Circadian Rhythm of Body Temperature in Man
Charles, A. C., Janet, C. Z., Joseph, M. R., Martin, C. M.-E., & Elliot, D. W. (1980) · Sleep · doi:10.1093/sleep/2.3.329 · Cited by 362 · see citing works
Integrated view of resetting a circadian clock
Winfree, A. T. (1970) · Journal of Theoretical Biology · doi:10.1016/0022-5193(70)90075-5 · Cited by 350 · see citing works
Human Circadian Rhythms in Continuous Darkness: Entrainment by Social Cues
Aschoff, J., Fatranská, M., Giedke, H., Doerr, P., Stamm, D., & Wisser, H. (1971) · Science · doi:10.1126/science.171.3967.213 · Cited by 348 · see citing works
Regulation of circadian rhythmicity.
Takahashi, J. S., & Zatz, M. (1982) · Science · doi:10.1126/science.6287576 · Cited by 314 · see citing works
Adaptation to abrupt time shifts of the oscillator(s) controlling human circadian rhythms.
Mills, J. N., Minors, D. S., & Waterhouse, J. M. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012582 · Cited by 285 · see citing works
Supersensitivity to light: possible trait marker for manic-depressive illness
Lewy, A. J., Nürnberger, J. I., Wehr, T. A., Pack, D., Becker, L. E., Powell, R. L., & Newsome, D. A. (1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.6.725 · Cited by 284 · see citing works
Some effects of jet-lag and their alleviation by melatonin
Arendt, J., Aldhous, M. E., English, J., Marks, V., Arendt, J., Marks, M., & Folkard, S. (1987) · Ergonomics · doi:10.1080/00140138708966031 · Cited by 276 · see citing works
Circadian Rhythm of Optic Nerve Impulses Recorded in Darkness from Isolated Eye of Aplysia
Jacklet, J. W. (1969) · Science · doi:10.1126/science.164.3879.562 · Cited by 266 · see citing works
Stimulated activity mediates phase shifts in the hamster circadian clock induced by dark pulses or benzodiazepines
Reeth, O. V., & Turek, F. W. (1989) · Nature · doi:10.1038/339049a0 · Cited by 257 · see citing works
Blind Man Living in Normal Society Has Circadian Rhythms of 24.9 Hours
Miles, L. E. M., Raynal, D., & Wilson, M. A. (1977) · Science · doi:10.1126/science.910139 · Cited by 251 · see citing works
A PERSISTENT DIURNAL RHYTHM OF LUMINESCENCE IN GONYAULAX POLYEDRA
Hastings, J. W., & Sweeney, B. M. (1958) · Biological Bulletin · doi:10.2307/1539108 · Cited by 249 · see citing works
ENTRAINMENT OF HUMAN ORCADIAN RHYTHMS BY LIGHT-DARK CYCLES: A REASSESSMENT
Czeisler, C. A., Richardson, G. S., Zimmerman, J. C., Moore‐Ede, M. C., & Weitzman, E. D. (1981) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1981.tb08993.x · Cited by 243 · see citing works
Self-citation
A behavioural method for accelerating re-entrainment of rhythms to new light—dark cycles
Mrosovsky, N., & Salmon, P. A. (1987) · Nature · doi:10.1038/330372a0 · Cited by 241 · see citing works
Suppression of Nocturnal Plasma Melatonin and 6-Sulphatoxymelatonin by Bright and Dim Light in Man
Bojkowski, C. J., Aldhous, M. E., English, J., Franey, C. S., Poulton, A. L., Skene, D. J., & Arendt, J. (1987) · Hormone and Metabolic Research · doi:10.1055/s-2007-1011846 · Cited by 233 · see citing works
Bright light affects human circadian rhythms
Wever, R., Polášek, J., & Wildgruber, C. M. (1983) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00584704 · Cited by 220 · see citing works
Phototherapy of Seasonal Affective Disorder
Wehr, T. A. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800090060008 · Cited by 217 · see citing works
Transplantation of the Cockroach Circadian Pacemaker
Page, T. L. (1982) · Science · doi:10.1126/science.216.4541.73 · Cited by 201 · see citing works
Winter Depression and the Phase-Shift Hypothesis for Bright Light's Therapeutic Effects: History, Theory, and Experimental Evidence
Lewy, A. J., Sack, R. L., Singer, C. M., Whate, D. M., & Hoban, T. M. (1988) · Journal of Biological Rhythms · doi:10.1177/074873048800300203 · Cited by 190 · see citing works
ENTRAINMENT OF HUMAN ORCADIAN RHYTHMS BY LIGHT-DARK CYCLES: A REASSESSMENT
Czeisler, C. A., Richardson, G. S., Zimmerman, J. C., et al. (1981) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1981.tb09354.x · Cited by 175 · see citing works
Self-citation
Scheduled exposure to daylight: a potential strategy to reduce "jet lag" following transmeridian flight.
Daan, S., & Aj, L. (1984) · PubMed · Cited by 139 · see citing works
Circadian rhythm in rat retinal dopamine
Wirz‐Justice, A., Prada, M. D., & Remé, C. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90323-9 · Cited by 138 · see citing works
Evidence for both local and central regulation of rat rod outer segment disc shedding.
Teirstein, P. S., Goldman, A. I., & O'Brien, P. J. (1980) · PubMed · Cited by 136 · see citing works
The use of Constant Routines in Unmasking the Endogenous Component of Human Circadian Rhythms
Minors, D. S., & Waterhouse, J. M. (1984) · Chronobiology International · doi:10.3109/07420528409063897 · Cited by 127 · see citing works
Biologic rhythm disorders, depression, and phototherapy. A new hypothesis.
Czeisler, C. A., Kronauer, R. E., Mooney, J. J., Anderson, J. L., & Allan, J. S. (1987) · PubMed · Cited by 127 · see citing works
Self-citation
Phase-dependent shift of free-running human circadian rhythms in response to a single bright pulse
Honma, K., Honma, S., & Wada, T. (1987) · Cellular and Molecular Life Sciences · doi:10.1007/bf01945525 · Cited by 117 · see citing works
Light Synchronization of the Circadian Rhythm in Plasma Cortisol (17-OHCS) Concentration in Man
Orth, D. N., & Island, D. P. (1969) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-29-4-479 · Cited by 116 · see citing works
Atenolol in seasonal affective disorder: a test of the melatonin hypothesis
Rosenthal, N. E., Jacobsen, F. M., Sack, D. A., Arendt, J., James, S. P., Parry, B. L., & Wehr, T. A. (1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.1.52 · Cited by 111 · see citing works
Biologic Rhythm Disorders, Depression, and Phototherapy
Czeisler, C. A., Kronauer, R. E., Mooney, J. J., Anderson, J. L., & Allan, J. S. (1987) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30543-4 · Cited by 105 · see citing works
Self-citation
Localization of a Circadian Pacemaker in the Eye of a Mollusc, Bulla
Block, G. D., & Wallace, S. F. (1982) · Science · doi:10.1126/science.217.4555.155 · Cited by 101 · see citing works
Different oscillators control the circadian rhythm of eclosion and activity inDrosophila
Engelmann, W., & Mack, J. (1978) · Journal of Comparative Physiology A · doi:10.1007/bf01350113 · Cited by 94 · see citing works
Circadian Regulation Dominates Homeostatic Control of Sleep Length and Prior Wake Length in Humans
Strogatz, S. H., Kronauer, R. E., & Czeisler, C. A. (1986) · SLEEP · doi:10.1093/sleep/9.2.353 · Cited by 92 · see citing works
Self-citation
Zur Zeitgeber-St�rke eines Licht-Dunkel-Wechsels f�r die circadiane Periodik des Menschen
Wever, R. A. (1970) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00586368 · Cited by 87 · see citing works
FREE‐RUNNING CIRCADIAN PLASMA CORTISOL RHYTHM IN A BLIND HUMAN SUBJECT
Orth, D. N., BESSER, G. M., King, P. H., & Nicholson, W. E. (1979) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1979.tb02120.x · Cited by 81 · see citing works
A Circadian Pacemaker for Visual Sensitivity?a
Terman, M., & Terman, J. S. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb11807.x · Cited by 74 · see citing works
A limit cycle interpretation of a mosquito circadian oscillator
Peterson, E. L. (1980) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(80)80008-7 · Cited by 67 · see citing works
Circadian changes in the response of the rabbit's retina to flashes
Brandenburg, J., Bobbert, A. C., & Eggelmeyer, F. (1983) · Behavioural Brain Research · doi:10.1016/0166-4328(83)90008-6 · Cited by 65 · see citing works
Effects of light on human melatonin production and the human circadian system
Lewy, A. J. (1983) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(83)90024-6 · Cited by 60 · see citing works
Insomnia during the “dark period” in northern Norway
Lingærde, O., Bratlid, T., & Hansen, T. (1985) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1985.tb05064.x · Cited by 57 · see citing works
Inducing jet lag in the laboratory: patterns of adjustment to an acute shift in routine.
Monk, T. H., Moline, M. L., & Graeber, R. C. (1988) · PubMed · Cited by 48 · see citing works
Notizen: Weak and Strong Phase Shifting in the Activity Rhythm of Leucophaea maderae (Blaberidae)after Light Pulses of High Intensity
Wiedenmann, G. (1977) · Zeitschrift für Naturforschung C · doi:10.1515/znc-1977-5-630 · Cited by 28 · see citing works
Tagesrhythmische Schwankungen der visuellen Lichtempfindlichkeit beim Menschen
Knoerchen, R., & Hildebrandt, G. (1976) · Journal of Interdisiplinary Cycle Research · doi:10.1080/09291017609359505 · Cited by 23 · see citing works
Standards for Use of Visible and Nonvisible Radiation on the Eye
Sliney, D. H. (1983) · Optometry and Vision Science · doi:10.1097/00006324-198304000-00003 · Cited by 22 · see citing works
Endogenous circadian retinomotor movements in the neon tetra (Paracheirodon innesi).
LYTHGOE, J. N., & Shand, J. (1983) · PubMed · Cited by 18 · see citing works
Sinemet in Parkinsonʼs Disease
Bozek, C. B., Suchowersky, O., Purves, S., et al. (1986) · Clinical Neuropharmacology · doi:10.1097/00002826-198604000-00011 · Cited by 13 · see citing works
Melatonin secretion as a neurobiological "marker" and effects of light in humans.
Lewy, A. J., Wehr, T. A., Rosenthal, N. E., et al. (1982) · PubMed · Cited by 12 · see citing works
A linear oscillator model for circadian rhythms: implications for phase response curves.
Sinha, S. (1982) · PubMed · Cited by 3 · see citing works

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Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., et al. (1999) · Science · doi:10.1126/science.284.5423.2177 · Cited by 1,705 · see citing works
Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression
Zeitzer, J. M., Dijk, D., Kronauer, R. E., Brown, E. N., & Czeisler, C. A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00695.x · Cited by 1,175 · see citing works
Self-citation
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Khalsa, S. B. S., Jewett, M. E., Cajochen, C., & Czeisler, C. A. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.040477 · Cited by 1,040 · see citing works
Self-citation
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Ramsay, J. O., Hooker, G., Campbell, D., & Cao, J. (2007) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.1467-9868.2007.00610.x · Cited by 613 · see citing works
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Czeisler, C. A., Johnson, M. P., Duffy, J. F., Brown, E. N., Ronda, J. M., & Kronauer, R. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005033221801 · Cited by 580 · see citing works
Self-citation
Dose-response relationships for resetting of human circadian clock by light
Boivin, D. B., Duffy, J. F., Kronauer, R. E., & Czeisler, C. A. (1996) · Nature · doi:10.1038/379540a0 · Cited by 559 · see citing works
Self-citation
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Duffy, J. F., & Wright, K. P. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405277983 · Cited by 515 · see citing works
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Baker, F. C., & Driver, H. S. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.09.011 · Cited by 529 · see citing works
A model of human sleep homeostasis based on EEG slow-wave activity: Quantitative comparison of data and simulations
Achermann, P., Dijk, D.-J., Brunner, D. P., & Borbély, A. A. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90016-5 · Cited by 470 · see citing works
Association of sleep-wake habits in older people with changes in output of circadian pacemaker
Czeisler, C. A., Dumont, M., Duffy, J. F., Steinberg, J. D., Richardson, G. S., Brown, E. N., Sánchez, R., Ríos, C. D., & Ronda, J. M. (1992) · The Lancet · doi:10.1016/0140-6736(92)92817-y · Cited by 437 · see citing works
Self-citation
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Czeisler, C. A., & Gooley, J. J. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.064 · Cited by 425 · see citing works
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Balbo, M., Leproult, R., & Van Cauter, E. (2010) · International Journal of Endocrinology · doi:10.1155/2010/759234 · Cited by 408 · see citing works
“Indeed, in studies of real and simulated jet-lag, the synchronization of the acrophase to the new clocktime occurred faster than the adaptation of the quiescent period [14, 66].”
Background
Complex Interaction of the Sleep-Wake Cycle and Circadian Phase Modulates Mood in Healthy Subjects
Boivin, D. B. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830140055010 · Cited by 378 · see citing works
Circadian Time of Morning Light Administration and Therapeutic Response in Winter Depression
Terman, J. S., Terman, M., Lo, E.-S., & Cooper, T. B. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.1.69 · Cited by 366 · see citing works
Aging and circadian rhythms
Duffy, J. F., Zitting, K.-M., & Chinoy, E. D. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.08.002 · Cited by 367 · see citing works
Self-citation
The Durations of Human Melatonin Secretion and Sleep Respond to Changes in Daylength (Photoperiod)
WEHR, T. A. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-6-1276 · Cited by 320 · see citing works
The relationship between insomnia and body temperatures
Lack, L. C., Gradisar, M., Van Someren, E. J. W., Wright, H. R., & Lushington, K. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.02.003 · Cited by 285 · see citing works
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Mistlberger, R. E., & Skene, D. J. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405277982 · Cited by 267 · see citing works
Illumination levels in nursing home patients: effects on sleep and activity rhythms
Shochat, T., Martin, J., Marler, M., & Ancoli‐Israel, S. (2000) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2000.00221.x · Cited by 262 · see citing works
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Zeitzer, J. M., Daniels, J. E., Duffy, J. F., Klerman, E. B., Shanahan, T. L., Dijk, D.-J., & Czeisler, C. A. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00266-1 · Cited by 239 · see citing works
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Simulation of daytime vigilance by the additive interaction of a homeostatic and a circadian process
Achermann, P., & Borbély, A. A. (1994) · Biological Cybernetics · doi:10.1007/bf00197314 · Cited by 180 · see citing works
MODIFICATIONS TO WEEKEND RECOVERY SLEEP DELAY CIRCADIAN PHASE IN OLDER ADOLESCENTS
Crowley, S. J., & Carskadon, M. A. (2010) · Chronobiology International · doi:10.3109/07420528.2010.503293 · Cited by 172 · see citing works
Exercise as a synchroniser of human circadian rhythms: an update and discussion of the methodological problems
Atkinson, G., Edwards, B., Reilly, T., & Waterhouse, J. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0361-z · Cited by 167 · see citing works
Rest-Activity Patterns of Premature Infants Are Regulated by Cycled Lighting
Rivkees, S. A., Mayes, L., Jacobs, H., & Gross, I. (2004) · Pediatrics · doi:10.1542/peds.113.4.833 · Cited by 155 · see citing works
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Self-citation
Dynamic resetting of the human circadian pacemaker by intermittent bright light
Rimmer, D. W., Boivin, D. B., Shanahan, T. L., Kronauer, R. E., Duffy, J. F., & Czeisler, C. A. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.5.r1574 · Cited by 139 · see citing works
Self-citation
Nondrug treatment trials in psychophysiologic insomnia
Guilleminault, C. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430080076010 · Cited by 140 · see citing works
Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs
Srinivasan, V., Singh, J., Pandi-Perumal, S. R., Brown, G. M., Spence, D. W., & Cardinali, D. P. (2010) · Advances in Therapy · doi:10.1007/s12325-010-0065-y · Cited by 129 · see citing works
Melatonin and Human Chronobiology
Lewy, A. J. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.055 · Cited by 129 · see citing works
The Relationship Between the Dim Light Melatonin Onset and Sleep on a Regular Schedule in Young Healthy Adults
Burgess, H. J., Savic, N., Sletten, T., Roach, G., Gilbert, S. S., & Dawson, D. (2003) · Behavioral Sleep Medicine · doi:10.1207/s15402010bsm0102_3 · Cited by 125 · see citing works
Annual variation in daily light exposure and circadian change of melatonin and cortisol concentrations at a northern latitude with large seasonal differences in photoperiod length
Adamsson, M., Laike, T., & Morita, T. (2017) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-016-0103-9 · Cited by 111 · see citing works
Midday exposure to bright light changes the circadian organization of plasma melatonin rhythm in humans
Hashimoto, S., Kohsaka, M., Nakamura, K., Honma, H., Honma, S., & Honma, K.-I. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13291-2 · Cited by 101 · see citing works
Bigger, brighter, bluer-better? Current light-emitting devices—Adverse sleep properties and preventative strategies
Gringras, P., Middleton, B., Skene, D. J., & Revell, V. L. (2015) · Frontiers in Public Health · doi:10.3389/fpubh.2015.00233 · Cited by 100 · see citing works
Gender differences in the temporal organization of proclactin (PRL) secretion: evidence for a sleep-independent circadian rhythm of circulating PRL levels- a clinical research center study.
Waldstreicher, J., Duffy, J. F., Brown, E. N., Rogacz, S., Allan, J. S., & Czeisler, C. A. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636355 · Cited by 100 · see citing works
Self-citation
Phase advancing human circadian rhythms with morning bright light, afternoon melatonin, and gradually shifted sleep: can we reduce morning bright-light duration?
Crowley, S. J., & Eastman, C. I. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2014.12.004 · Cited by 99 · see citing works
Photic Resetting in Night-Shift Work: Impact on Nurses' Sleep
Boivin, D. B., Boudreau, P., James, F. O., & Kin, N. M. K. N. Y. (2012) · Chronobiology International · doi:10.3109/07420528.2012.675257 · Cited by 95 · see citing works
The etiology of delayed sleep phase disorder
Micic, G., Lovato, N., Gradisar, M., Ferguson, S. A., Burgess, H. J., & Lack, L. C. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.06.004 · Cited by 84 · see citing works
Effects of nocturnal bright light on saliva melatonin, core body temperature and sleep propensity rhythms in human subjects
Kubota, T., Uchiyama, M., Suzuki, H., Shibui, K., Kim, K., Tan, X., Tagaya, H., Okawa, M., & Inoué, S. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(01)00310-8 · Cited by 80 · see citing works
The retinal iprgc-preoptic circuit mediates the acute effect of light on sleep
Zhang, Z., Beier, C., Weil, T., & Hattar, S. (2021) · Nature Communications · doi:10.1038/s41467-021-25378-w · Cited by 75 · see citing works
Treating chronobiological components of chronic insomnia
Lack, L. C., & Wright, H. R. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.10.003 · Cited by 74 · see citing works
The Influence of Different Wavelengths of Light on Human Biological Rhythms.
Morita, T., & Tokura, H. (1998) · APPLIED HUMAN SCIENCE Journal of Physiological Anthropology · doi:10.2114/jpa.17.91 · Cited by 73 · see citing works
Effects of illumination on human nocturnal serum melatonin levels and performance
Dollins, A. B., Lynch, H. J., Wurtman, R. J., Deng, M. H., & Lieberman, H. R. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90024-a · Cited by 72 · see citing works
Light exposure behaviors predict mood, memory and sleep quality
Siraji, M. A., Spitschan, M., Kalavally, V., & Haque, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-39636-y · Cited by 69 · see citing works
Sleep and circadian rhythms in mining operators: Limited evidence of adaptation to night shifts
Ferguson, S. A., Kennaway, D. J., Baker, A., Lamond, N., & Dawson, D. (2012) · Applied Ergonomics · doi:10.1016/j.apergo.2011.11.003 · Cited by 69 · see citing works
The Human Circadian Timing System and Sleep-Wake Regulation
Czeisler, C. A., Buxton, O. M., & Khalsa, S. B. S. (2005) · Principles and Practice of Sleep Medicine · doi:10.1016/b0-72-160797-7/50038-0 · Cited by 67 · see citing works
Self-citation
Sleep and circadian rhythm during a short space mission
Gundel, A., Nalishiti, V., Reucher, E., Vejvoda, M., & Zulley, J. (1993) · The Clinical Investigator · doi:10.1007/bf00209726 · Cited by 65 · see citing works
Circadian phase resetting by a single short-duration light exposure
Rahman, S. A., St. Hilaire, M. A., Chang, A.-M., Santhi, N., Duffy, J. F., Kronauer, R. E., Czeisler, C. A., Lockley, S. W., & Klerman, E. B. (2017) · JCI Insight · doi:10.1172/jci.insight.89494 · Cited by 61 · see citing works
“Introduction Light is the strongest environmental time cue for resetting the circadian clock in mammals, including humans (1, 2).”
BackgroundSelf-citation
Functional decoupling of melatonin suppression and circadian phase resetting in humans
Rahman, S. A., St Hilaire, M. A., Gronfier, C., Chang, A., Santhi, N., Czeisler, C. A., Klerman, E. B., & Lockley, S. W. (2018) · The Journal of Physiology · doi:10.1113/jp275501 · Cited by 58 · see citing works
Self-citation
Effect of Sex, Menstrual Cycle Phase, and Oral Contraceptive Use on Circadian Temperature Rhythms
Kattapong, K. R., Fogg, L. F., & Eastman, C. I. (1995) · Chronobiology International · doi:10.3109/07420529509057274 · Cited by 57 · see citing works
Aging young sleep: A test of the phase advance hypothesis of sleep disturbance in the elderly
CAMPBELL, S. S., & DAWSON, D. (1992) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1992.tb00040.x · Cited by 55 · see citing works
Strong resetting of the mammalian clock by constant light followed by constant darkness
Chen, R., Seo, D.-O., Bell, E., von Gall, C., & Lee, C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2191-08.2008 · Cited by 53 · see citing works
Regulation of the 24-hour rhythm of body temperature in menstrual cycles with spontaneous and gonadotropin-induced ovulation
Cagnacci, A., Volpe, A., Paoletti, A. M., & Melis, G. B. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00242-2 · Cited by 53 · see citing works
Factors Disrupting Melatonin Secretion Rhythms During Critical Illness
Maas, M. B., Lizza, B. D., Abbott, S. M., Liotta, E. M., Gendy, M., Eed, J., Naidech, A. M., Reid, K. J., & Zee, P. C. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004333 · Cited by 53 · see citing works
Sleep propensity and sleep architecture after bright light exposure at three different times of day
CARRIER, J., & DUMONT, M. (1995) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1995.tb00171.x · Cited by 50 · see citing works
Photoperiodic and circadian bifurcation theories of depression and mania
Kripke, D. F., Elliott, J. A., Welsh, D. K., & Youngstedt, S. D. (2015) · F1000Research · doi:10.12688/f1000research.6444.1 · Cited by 48 · see citing works
Photoperiod differentially modulates photic and nonphotic phase response curves of hamsters
Evans, J. A., Elliott, J. A., & Gorman, M. R. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00456.2003 · Cited by 45 · see citing works
Mood regulation in seasonal affective disorder patients and healthy controls studied in forced desynchrony
Koorengevel, K. M., Beersma, D. G. M., den Boer, J. A., & van den Hoofdakker, R. H. (2003) · Psychiatry Research · doi:10.1016/s0165-1781(02)00305-0 · Cited by 42 · see citing works
Circadian rhythm sleep-wake phase disorders
Culnan, E., McCullough, L. M., & Wyatt, J. K. (2019) · Neurologic Clinics · doi:10.1016/j.ncl.2019.04.003 · Cited by 42 · see citing works
School start time, sleepiness and functioning in Norwegian adolescents
Vedaa, Ø., West Saxvig, I., Wilhelmsen-Langeland, A., Bjorvatn, B., & Pallesen, S. (2012) · Scandinavian Journal of Educational Research · doi:10.1080/00313831.2011.567396 · Cited by 39 · see citing works
The human habenula is responsive to changes in luminance and circadian rhythm
Kaiser, C., Kaufmann, C., Leutritz, T., Arnold, Y. L., Speck, O., & Ullsperger, M. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.01.064 · Cited by 28 · see citing works
Decreased Sensitivity to Light of the Photic Entrainment Pathway during Chronic Clorgyline and Lithium Treatments
Duncan, W. C., Johnson, K. A., & Wehr, T. A. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098129000165 · Cited by 20 · see citing works
The bright and dark side of blue-enriched light on sleep and activity in older adults.
Barroggi Constantino, D., Lederle, K. A., Middleton, B., Revell, V. L., Sletten, T. L., Williams, P., Skene, D. J., & van der Veen, D. R. (2025) · GeroScience · doi:10.1007/s11357-025-01506-y · Cited by 9 · see citing works

Authors: Czeisler, C. A., Kronauer, R. E., Allan, J. S., Duffy, J. F., Jewett, M. E., Brown, E. N., & Ronda, J. M.
Affiliations: Brigham and Women's Hospital (US)
Harvard University (US)
ORCID: Czeisler, Charles A.
Allan, James S.
Duffy, Jeanne F.
Brown, Emery N.
Ronda, Joseph M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1989-06-16
Volume: 244
Issue: 4910
Pages: 1328-1333
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.2734611
OpenAlex: W2029323550
Cited by: 946
References: 57
Citations by year: 2026: 9 · 2025: 15 · 2024: 14 · 2023: 19 · 2022: 25 · 2021: 20 · 2020: 26 · 2019: 24 · 2018: 21 · 2017: 25 · 2016: 19 · 2015: 17 · 2014: 23 · 2013: 17 · 2012: 28
FWCI: 22.43
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (2s07rr005950-07)
National Institute on Aging (R01AG006072, 1-RO1-AG06072)
National Center for Research Resources (5 M01-RR-00888, 2-S07-RR05950)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
Keywords: circadian pacemaker, light-induced phase shift, bright light exposure, phototherapy, circadian rhythm disorders, photoperiod
MeSH terms: Adult, Circadian Rhythm, Humans, Male, Models, Biological, Phototherapy, Time Factors

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Bright Light Induction of Strong (Type 0) Resetting of the Human Circadian Pacemaker

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