Effects of the antiprogesterone RU 486 on preterm birth in the rat
Abstract
The effects of the antiprogesterone compound RU 486 on preterm delivery, myometrial gap junctions, and plasma levels of steroid hormones were investigated in pregnant rats. Injection of RU 486 on day 16 of gestation resulted in prolonged delivery beginning after 24 hours. The preterm birth initiated by RU 486 was preceded and accompanied by the extensive development of gap junctions between myometrial cells. R 5020, but neither progesterone nor dexamethasone, prevented preterm birth and the development of gap junctions. Estrogen and progesterone levels declined after RU 486 treatment but only after a major proportion of the fetuses were delivered. This study indicates that progesterone may normally inhibit uterine contractility by suppressing the genome responsible for the expression of gap junctions.
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A decrease in local progesterone concentrations or receptor number is a plausible mechanism for labour initiation, because progesterone antagonists initiate preterm labour and progestational agents prevent it.
“however, because progesterone antagonists—such as RU486—initiate preterm labour and progestational agents prevent preterm labour, a decrease in local progesterone concentrations or in the number of receptors is a plausible mechanism for initiation of labour.16, 17, 18”
From Epidemiology and causes of preterm birth (2008) · cites this paper as [17]
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- Authors
- Garfield, R. E., Gasc, J. M., & Baulieu, E. E.
- Affiliations
- McMaster University (CA)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1987-11
- Volume
- 157
- Issue
- 5
- Pages
- 1281-1285
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2088704507
- Cited by
- 79
- References
- 20
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 3 · 2012: 3
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- RU486, mifepristone, antiprogesterone, preterm birth, myometrium, gap junctions, progesterone, estrogen, steroid hormones, uterine contractility, pregnancy, dexamethasone
- MeSH terms
- Animals, Estrenes, Female, Intercellular Junctions, Obstetric Labor, Premature, Myometrium, Pregnancy, Pregnancy Maintenance, Progesterone, Rats, Inbred Strains, Mifepristone, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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