The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Maternal corticotropin-releasing hormone levels in the early third trimester predict length of gestation in human pregnancy
Open accessAbstract
Objective Corticotropin releasing hormone, a hypothalamic neuropeptide, plays a major role in regulating pituitary-adrenal function and the physiologic response to stress. During pregnancy corticotropin-releasing hormone is synthesized in large amounts by the placenta and released into the maternal and fetal circulations. Various endocrine, autocrine, and paracrine roles have been suggested for placental corticotropin-releasing hormone. The aim of this study was to prospectively assess the relationship between maternal plasma concentrations of corticotropin-releasing hormone in the early third trimester of pregnancy and the length of gestation in two groups of deliveries, with and without spontaneous labor. Study design In a sample of 63 women with singleton intrauterine pregnancies, maternal plasma samples were collected between 28 and 30 weeks' gestation and corticotropin-releasing hormone concentrations were determined by radioimmunoassay. Each pregnancy was dated on the basis of last menstrual period and early ultrasonography. Parity, antepartum risk conditions, presence or absence of spontaneous labor, and birth outcomes were abstracted from the medical record. Results Maternal corticotropin-releasing hormone levels between 28 and 30 weeks' gestation significantly and negatively predicted gestational length (P < .01) after adjustment for antepartum risk. Moreover, subjects who were delivered preterm had significantly higher corticotropin-releasing hormone levels in the early third trimester (P < .01) than did those who were delivered at term. In deliveries preceded by spontaneous onset of labor, maternal third-trimester corticotropin-releasing hormone levels significantly and independently predicted earlier onset of labor (P < .01) and preterm labor (P < .05), whereas in deliveries effected by induction of labor or cesarean delivery, maternal corticotropin-releasing hormone levels were a marker of antepartum risk but not a statistically independent predictor of gestational length. Conclusion These findings support the premise that placental corticotropin-releasing hormone is potentially implicated in the timing of human delivery in at least two ways. First, placental corticotropin-releasing hormone may play a role in the physiology of parturition. Premature or accelerated activation of the placental corticotropin-releasing hormone system, as reflected by precocious elevation of maternal corticotropin-releasing hormone levels, may therefore be associated with earlier onset of spontaneous labor and resultant delivery. Second, placental corticotropin-releasing hormone may be a marker of antepartum risk for preterm delivery and therefore an indirect predictor of earlier delivery. The implications of these findings are discussed in the context of the neuroendocrinology of placental corticotropin-releasing hormone and human parturition. Furthermore, the role of corticotropin-releasing hormone as a possible effector of prenatal stress in producing alterations in the timing of normal delivery is detailed.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Women experiencing high levels of psychosocial stress during pregnancy are at significantly increased risk for shortened gestation and preterm delivery, even after accounting for the effects of established risk factors such as sociodemographic, biophysical, biomedical, and behavioral [76].”
From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [76]
Citations
Cites
A placental clock controlling the length of human pregnancy
McLean, M. P., Bisits, A. M., Davies, J., Woods, R., Lowry, P., & Smith, R. (1995) · Nature Medicine · doi:10.1038/nm0595-460 · Cited by 907
Wadhwa, P. D., Sandman, C. A., Porto, M., Dunkel-Schetter, C., & Garite, T. J. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90016-c · Cited by 794
Self-citationGlucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta.
Robinson, B. G., Emanuel, R. L., Frim, D. M., & Majzoub, J. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5244 · Cited by 440
Romero, R. J., Mazor, M., Muñoz, H., Gómez, R., Galasso, M., & Sherer, D. M. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb21771.x · Cited by 405
Plasma Corticotropin-Releasing Hormone Concentrations During Pregnancy and Parturition*
CAMPBELL, E. A., Linton, E. A., Wolfe, C. D. A., Scraggs, P. R., Jones, M. T., & Lowry, P. J. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-5-1054 · Cited by 386
Peptide Signaling in Human Placenta and Membranes: Autocrine, Paracrine, and Endocrine Mechanisms*
Petraglia, F., Florio, P., Nappi, C., & GENAZZANI, A. R. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-156 · Cited by 350
Prenatal Psychosocial Factors and the Neuroendocrine Axis in Human Pregnancy
Wadhwa, P. D., Dunkel‐Schetter, C., Chicz-DeMet, A., Porto, M., & Sandman, C. A. (1996) · Psychosomatic Medicine · doi:10.1097/00006842-199609000-00006 · Cited by 311
Self-citationKaralis, K. P., Goodwin, G., & Majzoub, J. A. (1996) · Nature Medicine · doi:10.1038/nm0596-556 · Cited by 248
Chrousos, G. P. (1992) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30191-9 · Cited by 184
Orth, D. N., & Mount, C. D. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)91369-6 · Cited by 182
Plasma corticotrophin‐releasing factor (CRF) in abnormal pregnancy
Wolfe, C. D. A., CAMPBELL, E. A., Anderson, J., Jones, M. T., PATEL, S. P., Dornhorst, A., Linton, E. A., & Lowry, P. J. (1988) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1988.tb06504.x · Cited by 162
Warren, W. B., Patrick, S. L., & Goland, R. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(11)90606-1 · Cited by 157
Current topic: The placental corticotrophin-releasing hormone-adrenocorticotrophin axis
Challis, J. R. G., Matthews, S. G., van Meir, C. A., & Ramirez, M. M. (1995) · Placenta · doi:10.1016/s0143-4004(05)80001-3 · Cited by 117
Perkins, A. V., Linton, E. A., Eben, F., Simpson, J. A., Wolfe, C. D. A., & Redman, C. W. G. (1995) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1995.tb09063.x · Cited by 111
Lockwood, C. J. (1994) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/00001703-199402000-00003 · Cited by 110
Hillhouse, E. W., Grammatopoulos, D., Milton, N. G., & Quartero, H. W. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.3.8383145 · Cited by 110
Berkowitz, G. S., Lapinski, R. H., Lockwood, C. J., Florio, P., Blackmore-Prince, C., & Petraglia, F. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70591-4 · Cited by 83
Placental CRH Modulates Maternal Pituitary‐Adrenal Function in Human Pregnancya
Wadhwa, P. D., Sandman, C. A., Chicz-DeMet, A., & Porto, M. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb46163.x · Cited by 68
Self-citationCorticotrophin-releasing hormone and β-endorphin in labour
McLean, M. P., Thompson, D., Zhang, H.-P., Brinsmead, M., & Smith, R. (1994) · European Journal of Endocrinology · doi:10.1530/eje.0.1310167 · Cited by 58
Petraglia, F., Aguzzoli, L., Florio, P., Baumann, P., Genazzani, A. D., Carlo, C. D., & Romero, R. J. (1995) · Placenta · doi:10.1016/0143-4004(95)90004-7 · Cited by 56
Quartero, H. W. P., Noort, W. A., Fry, C. H., & Keirse, M. J. N. C. (1991) · Prostaglandins · doi:10.1016/0090-6980(91)90073-o · Cited by 50
A Review of Risk Scoring for Preterm Birth
Shiono, P. H., & Klebanoff, M. A. (1993) · Clinics in Perinatology · doi:10.1016/s0095-5108(18)30414-7 · Cited by 50
Kurki, T., Laatikainen, T., Salminen-Lappalainen, K., & LAVIYLIKORKALA, O. (1991) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1991.tb13456.x · Cited by 46
Souza, E. B. D. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb49919.x · Cited by 43
Sue-Tang, A., Booking, A. D., Brooks, A. N., Hooper, S. B., White, S. E., Jacobs, R. A., Fraher, L. J., & Challis, J. R. G. (1992) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y92-196 · Cited by 31
Cited by
Sorted by citations
The long-term behavioural consequences of prenatal stress
Weinstock, M. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.002 · Cited by 1,098
Alterations induced by gestational stress in brain morphology and behaviour of the offspring
Weinstock, M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00018-1 · Cited by 791
Weinstock, M. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2004.09.006 · Cited by 706
Prenatal stress, glucocorticoids and the programming of adult disease
Cottrell, E. C. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.019.2009 · Cited by 640
Prenatal depression effects on the fetus and newborn: a review
Field, T., Diego, M., & Hernandez-Reif, M. (2006) · Infant Behavior and Development · doi:10.1016/j.infbeh.2006.03.003 · Cited by 592
Metadata
- Authors
- Wadhwa, P. D., Porto, M., Garite, T. J., Chicz-DeMet, A., & Sandman, C. A.
- Affiliations
- University of Kentucky (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 179
- Issue
- 4
- Pages
- 1079-1085
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2129109829
- Cited by
- 251
- References
- 25
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 8 · 2015: 13 · 2014: 6 · 2013: 8 · 2012: 9
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- U.S. Public Health Service (P30 HD-28202, R01 HD-28413, R29HD-33506)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- corticotropin-releasing factor, placenta, third trimester, gestation length, preterm labor, spontaneous labor, childbirth, maternal plasma biomarkers, hypothalamic-pituitary-adrenal axis, pregnancy outcome prediction, labor induction, cesarean section, birth weight, birth length, birth position
- MeSH terms
- Adult, Birth Weight, Cesarean Section, Corticotropin-Releasing Hormone, Female, Gestational Age, Humans, Labor, Induced, Obstetric Labor, Premature, Parity, Pregnancy, Pregnancy Trimester, Third, Multivariate Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
