Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta.
Open accessAbstract
Primary cultures of purified human cytotrophoblasts have been used to examine the expression of the corticotropin-releasing hormone (CRH) gene in placenta. We report here that glucocorticoids stimulate placental CRH synthesis and secretion in primary cultures of human placenta. This stimulation is in contrast to the glucocorticoid suppression of CRH expression in hypothalamus. The positive regulation of CRH by glucocorticoids suggests that the rise in CRH preceding parturition could result from the previously described rise in fetal glucocorticoids. Furthermore, this increase in placental CRH could stimulate, via adrenocorticotropic hormone, a further rise in fetal glucocorticoids, completing a positive feedback loop that would be terminated by delivery.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CRH produced in the placenta can stimulate ACTH production in the pituitary, leading to elevated levels of glucocorticoids.
“Interestingly, CRH produced in the placenta can stimulate ACTH production in the pituitary, leading to elevated levels of glucocorticoids.”
From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [70]
Glucocorticoids stimulate placental CRH synthesis and secretion in cultured human cytotrophoblasts.
“In turn, glucocorticoids have been shown to stimulate placental CRH synthesis and secretion in cultured human cytotrophoblasts [70].”
From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [70]
Cites
Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy
Tulchinsky, D., Hobel, C. J., Yeager, E., & Marshall, J. R. (1972) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(72)90185-8 · Cited by 564 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Weinstock, M. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2004.09.006 · Cited by 706 · see citing works
Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system
Whitnall, M. H. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90035-q · Cited by 582 · see citing works
When stress happens matters: Effects of earthquake timing on stress responsivity in pregnancy
Glynn, L. M., Wadhwa, P. D., Dunkel-Schetter, C., Chicz-DeMet, A., & Sandman, C. A. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.111066 · Cited by 508 · see citing works
The Contribution of Maternal Stress to Preterm Birth: Issues and Considerations
Wadhwa, P. D., Entringer, S., Buss, C., & Lu, M. C. (2011) · Clinics in Perinatology · doi:10.1016/j.clp.2011.06.007 · Cited by 486 · see citing works
Hobel, C. J., Dunkel-Schetter, C., Roesch, S. C., Castro, L. C., & Arora, C. P. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70712-x · Cited by 457 · see citing works
The hypothalamic-pituitary-adrenal axis in pregnancy: challenges in disease detection and treatment
Lindsay, J. R., & Nieman, L. K. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0025 · Cited by 449 · see citing works
Vamvakopoulos, N. C., & Chrousos, G. P. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116782 · Cited by 422 · see citing works
A longitudinal study of plasma and urinary cortisol in pregnancy and postpartum
Jung, C., Ho, J. T., Torpy, D. J., Rogers, A., Doogue, M., Lewis, J. G., Czajko, R. J., & Inder, W. J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2395 · Cited by 394 · see citing works
Ishimoto, H., & Jaffe, R. B. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0001 · Cited by 379 · see citing works
Pregnancy as a period of risk, adaptation, and resilience for mothers and infants
Davis, E. P., & Narayan, A. J. (2020) · Development and Psychopathology · doi:10.1017/s0954579420001121 · Cited by 297 · see citing works
“However, in contrast to the negative feedback at the level of the hypothalamus, cortisol stimulates the production of CRH from the placenta, similar to the role of cortisol in the amygdala (Robinson, Emanuel, Frim, & Majzoub, 1988).”
Stress and the HPA Axis: Balancing Homeostasis and Fertility.
Joseph, D., & Whirledge, S. (2017) · International journal of molecular sciences · doi:10.3390/ijms18102224 · Cited by 290 · see citing works
“In turn, glucocorticoids have been shown to stimulate placental CRH synthesis and secretion in cultured human cytotrophoblasts [70].”
BackgroundWadhwa, P. D., Porto, M., Garite, T. J., Chicz-DeMet, A., & Sandman, C. A. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70219-4 · Cited by 251 · see citing works
Neuroendocrine Mechanisms in Pregnancy and Parturition
Petraglia, F., Imperatore, A., & Challis, J. R. G. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0019 · Cited by 224 · see citing works
Moawad, A. H., Goldenberg, R. L., Mercer, B., Meis, P. J., Iams, J. D., Das, A., Caritis, S. N., Miodovnik, M., Menard, M. K., Thurnau, G. R., et al. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.121727 · Cited by 100 · see citing works
Sirianni, R., Rehman, K. S., Carr, B. R., Parker, C. R., & Rainey, W. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0865 · Cited by 98 · see citing works
Pregnancy outcomes in women with congenital virilizing adrenal hyperplasia
Lo, J. C., & Grumbach, M. M. (2001) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(08)70027-6 · Cited by 98 · see citing works
Sun, K., Yang, K., & Challis, J. R. G. (1998) · Biology of Reproduction · doi:10.1095/biolreprod58.6.1379 · Cited by 86 · see citing works
Adrenal diseases during pregnancy: pathophysiology, diagnosis and management strategies
Kamoun, M., Mnif, M. F., Charfi, N., Kacem, F. H., Naceur, B. B., Mnif, F., Dammak, M., Rekik, N., & Abid, M. (2014) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31828aaeee · Cited by 77 · see citing works
Nomura, Y., Rompala, G., Pritchett, L., Aushev, V., Chen, J., & Hurd, Y. L. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01123-z · Cited by 48 · see citing works
DHEA in prenatal and postnatal life: implications for brain and behavior
Quinn, T., Greaves, R., Badoer, E., & Walker, D. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.03.001 · Cited by 28 · see citing works
- Authors
- Robinson, B. G., Emanuel, R. L., Frim, D. M., & Majzoub, J. A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1988-07
- Volume
- 85
- Issue
- 14
- Pages
- 5244-5248
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC281726
- OpenAlex
- W1997530953
- Cited by
- 440
- References
- 1
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 4 · 2022: 9 · 2021: 6 · 2020: 11 · 2019: 15 · 2018: 12 · 2017: 14 · 2016: 12 · 2015: 14 · 2014: 12 · 2013: 18 · 2012: 11
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
- Keywords
- corticotropin-releasing factor, glucocorticoids, human placenta, cytotrophoblast, CRH gene expression, childbirth, fetal glucocorticoids, ACTH, positive feedback loop
- MeSH terms
- Cells, Cultured, Corticotropin-Releasing Hormone, Dexamethasone, Endoribonucleases, Female, Gene Expression Regulation, Glucocorticoids, Histocytochemistry, Humans, Immunoenzyme Techniques, Nucleic Acid Hybridization, Placenta, Pregnancy, RNA, Messenger, Transcription, Genetic, Trophoblasts, Ribonuclease H
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
