The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Augmented Senile Plaque Load in Aged Female β-Amyloid Precursor Protein-Transgenic Mice
Open accessAbstract
Transgenic mice (Tg2576) overexpressing human beta-amyloid precursor protein with the Swedish mutation (APP695SWE) develop Alzheimer's disease-like amyloid beta protein (Abeta) deposits by 8 to 10 months of age. These mice show elevated levels of Abeta40 and Abeta42, as well as an age-related increase in diffuse and compact senile plaques in the brain. Senile plaque load was quantitated in the hippocampus and neocortex of 8- to 19-month-old male and female Tg2576 mice. In all mice, plaque burden increased markedly after the age of 12 months. At 15 and 19 months of age, senile plaque load was significantly greater in females than in males; in 91 mice studied at 15 months of age, the area occupied by plaques in female Tg2576 mice was nearly three times that of males. By enzyme-linked immunosorbent assay, female mice also had more Abeta40 and Abeta42 in the brain than did males, although this difference was less pronounced than the difference in histological plaque load. These data show that senescent female Tg2576 mice deposit more amyloid in the brain than do male mice, and may provide an animal model in which the influence of sex differences on cerebral amyloid pathology can be evaluated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Also as it has been reported with other APP/PS1 transgenic mice, we observed a sex-specific effect on amyloid deposition with 5XFAD female mice developing amyloid deposits earlier compared to male littermates [27], [31], [32].”
From Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model (2011) · cites this paper as [31]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“A similar sex-specific amyloid deposition phenotype has been previously reported with other APP transgenic mouse models (Callahan et al., 2001; Wang et al., 2003).”
From Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance (2009) · cites this paper as Callahan et al., 2001
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210
The efficiency of systematic sampling in stereology and its prediction*
Gundersen, H. J. G., & Jensen, E. B. V. (1987) · Journal of Microscopy · doi:10.1111/j.1365-2818.1987.tb02837.x · Cited by 3,519
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516
Gundersen, H. J. G., Bagger, P. V., Bendtsen, T. F., Evans, S. M., Korbo, L., Marcussen, N., Møller, A., Nielsen, K. N., Nyengaard, J. R., Pakkenberg, B., et al. (1988) · Apmis · doi:10.1111/j.1699-0463.1988.tb00954.x · Cited by 2,480
Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease
Tang, M., Jacobs, D. M., Stern, Y., Marder, K. S., Schofield, P., Gurland, B. J., Andrews, H., & Mayeux, R. P. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03356-9 · Cited by 1,647
Mullan, M., Crawford, F., Axelman, K., Houlden, H., Lilius, L., Winblad, B., & Lannfelt, L. (1992) · Nature Genetics · doi:10.1038/ng0892-345 · Cited by 1,513
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507
Amyloid, the presenilins and Alzheimer’s disease
Hardy, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01030-2 · Cited by 1,370
The prevalence of dementia: A quantitative integration of the literature
Jorm, A. F., Korten, A. E., & Henderson, A. S. (1987) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1987.tb02906.x · Cited by 1,301
Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease
Mulnard, R. A., Cotman, C. W., Kawas, C. H., van Dyck, C. H., Sano, M. C., Doody, R. S., Koss, E., Pfeiffer, E., Jin, S., Gamst, A., et al. (2000) · JAMA · doi:10.1001/jama.283.8.1007 · Cited by 989
Research works printed but not linked: 2
- Hsiao, 1997, Age-related neuropathology in transgenic mice with human mutant APP, Soc Neurosci Abstr, 23, 1647
- Campbell, 1987, Alzheimer's plaques and tangles: a controlled and enhanced silver staining method, Soc Neurosci Abstr, 13, 687
Cited by
Sorted by citations
Items 201–274 of 274
SENP1 and SENP2 regulate SUMOylation of amyloid precursor protein
Maruyama, T., Abe, Y., & Niikura, T. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00601 · Cited by 20
Animal Models of Psychosis in Alzheimer Disease
Krivinko, J. M., Koppel, J. L., Savonenko, A. V., & Sweet, R. A. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.05.009 · Cited by 19
Novel aspects of accumulation dynamics and Aβ composition in transgenic models of AD
Lewis, H. D., Beher, D., Smith, D., Hewson, L., Cookson, N., Reynolds, D. S., Dawson, G. R., Jiang, M., der Ploeg, L. H. T. V., Qian, S., et al. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.009 · Cited by 21
Brainwide distribution and variance of amyloid-beta deposits in tg-ArcSwe mice
Lillehaug, S., Skaaraas, G. H. E. S., Nilsson, L. N. G., Bjaalie, J. G., Leergaard, T. B., & Torp, R. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.013 · Cited by 18
Not all depression is created equal: sex interacts with disease to precipitate depression
Nemeth, C. L., Harrell, C. S., Beck, K. D., & Neigh, G. N. (2013) · Biology of Sex Differences · doi:10.1186/2042-6410-4-8 · Cited by 19
Singhaarachchi, P. H., Antal, P., Calon, F., Culmsee, C., Delpech, J.-C., Feldotto, M., Geertsema, J., Hoeksema, E. E., Kőrösi, A., Layé, S., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105724 · Cited by 20
Murakami, K., Watanabe, T., Koike, T., Kamata, M., Igari, T., & Kondo, S. (2015) · Brain Research · doi:10.1016/j.brainres.2015.12.016 · Cited by 18
Androvičová, R., Pfaus, J. G., & Ovsepian, S. V. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136038 · Cited by 19
Kim, D.-H., Jang, Y.-S., Jeon, W. K., & Han, J. (2019) · Experimental Neurobiology · doi:10.5607/en.2019.28.2.146 · Cited by 19
Augmented axonal defects and synaptic degenerative changes in female GRK5 deficient mice
Li, L., Rasul, I., Liu, J., Zhao, B., Tang, R., Premont, R. T., & Suo, W. Z. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.09.019 · Cited by 18
Lin, F., Jia, J., & Qin, W. (2014) · Neuroreport · doi:10.1097/wnr.0000000000000261 · Cited by 17
van Duijn, S., Nabuurs, R. J. A., van Duinen, S. G., Natté, R., van Buchem, M. A., & Alia, A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122188 · Cited by 16
Experience-dependent regulation of vesicular zinc in male and female 3xTg-AD mice
Nakashima, A. S., Oddo, S., LaFerla, F. M., & Dyck, R. H. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.028 · Cited by 16
The 5×FAD mouse model of Alzheimer's disease
Ismeurt, C., Giannoni, P., & Claeysen, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815854-8.00013-6 · Cited by 18
Zhao, Z., Ning, Y., Li, P., Yang, N., Peng, Y., Xiong, R., Zhao, Y., Liu, D., Zeng, X., Chen, J., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.002 · Cited by 15
Wang, B., Tanaka, K., Ji, B., Ono, M., Fang, Y., Ninomiya, Y., Maruyama, K., Nakajima, N. I., Begum, N., Higuchi, M., et al. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23363 · Cited by 14
Rodent Models for Alzheimer’s Disease in Drug Discovery
Barrett, J. E., & McGonigle, P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802810-0.00012-x · Cited by 15
Cuadrado‐Tejedor, M., & García‐Osta, A. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2627-5_14 · Cited by 14
Selective Vulnerability of Neurons in Primary Cultures and in Neurodegenerative Diseases
Chen, J., & Herrup, K. (2008) · Reviews in the Neurosciences · doi:10.1515/revneuro.2008.19.4-5.317 · Cited by 15
The Past as Seen by Women and Men With Alzheimer Disease
Haj, M. E., Boutoleau‐Bretonnière, C., & Gallouj, K. (2020) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000363 · Cited by 15
Can Animal Models Inform on the Relationship between Depression and Alzheimer Disease?
Nyarko, J. N. K., Quartey, M. O., Baker, G. B., & Mousseau, D. D. (2018) · The Canadian Journal of Psychiatry · doi:10.1177/0706743718772514 · Cited by 12
Hanafy, A. S., Lamprecht, A., & Dietrich, D. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00492-7 · Cited by 11
Retinal Changes in Transgenic Mouse Models of Alzheimer’s Disease
Guo, L., Ravindran, N., Shamsher, E., Hill, D., & Cordeiro, M. F. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666210414113634 · Cited by 13
TSPO contributes to neuropathology and cognitive deficits in Alzheimer’s disease
Ceyzériat, K., Badina, A. M., Abjean, L., Meyer, L., Bouteldja, F., Bałkota, M., Amossé, Q., Prudhomme, O., Middleton, R. J., Liu, G.-J., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03583-4 · Cited by 14
Rizoska, B., Zachrisson, O., Appelkvist, P., Boström, E., Björklund, M., Rachalski, A., Gkanatsiou, E., Kylefjord, H., Söderberg, L., Nygren, P., et al. (2024) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2024.103950 · Cited by 10
Sex Differences in Hypothalamic Changes and the Metabolic Response of TgAPP Mice to a High Fat Diet
Freire‐Regatillo, A., Díaz-Pacheco, S., Frago, L. M., Arévalo, M., Argente, J., García‐Segura, L. M., CEBALLOS, M. L. D., & Chowen, J. A. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.910477 · Cited by 10
Ceyzériat, K., Jaques, E., Gloria, Y., Badina, A. M., Millet, P., Koutsouvelis, N., Dipasquale, G., Frisoni, G. B., Zilli, T., Garibotto, V., et al. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231153 · Cited by 10
Hunsberger, H. C., Lee, S., Jin, M., Lanio, M., Whye, A., Cha, J., Scarlata, M., Matthews, L. C., Jayaseelan, K., & Denny, C. A. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.09.016 · Cited by 10
Li, R., Ding, X.-W., Geetha, T., Fadamiro, M., Aubin, C. R. S., Shim, M., Al‐Nakkash, L., Broderick, T. L., & Babu, J. R. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1560435 · Cited by 9
Savonenko, A. V., Wong, P. C., & Li, T. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85654-6.00022-8 · Cited by 8
Amyloid-β Processing in Aged S100B Transgenic Mice Is Sex Dependent
Wartchow, K. M., Rodrigues, L., Swierzy, I. J., Buchfelder, M., Souza, D. O., Gonçalves, C., & Kleindienst, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910823 · Cited by 8
LeVine, H., & Walker, L. C. (2006) · Elsevier eBooks · doi:10.1016/b978-012369391-4/50012-6 · Cited by 8
Self-citationY10W β(1–40) fluorescence reflects epitope exposure in conformers of Alzheimer’s β-peptide
LeVine, H. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(03)00322-9 · Cited by 8
Fernández‐Fernández, D., Dorner‐Ciossek, C., Kroker, K. S., & Rosenbrock, H. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23701 · Cited by 7
Aβ∗56 is a stable oligomer that impairs memory function in mice
Liu, P., Lapcinski, I. P., Hlynialuk, C. J. W., Steuer, E. L., Loude, T. J., Shapiro, S. L., Kemper, L. J., & Ashe, K. H. (2024) · iScience · doi:10.1016/j.isci.2024.109239 · Cited by 6
Gender Differences in the Effects of Exercise Interventions on Alzheimer’s Disease
Dong, Y., Shi, L., Ma, Y., Liu, Y., Sun, Y., & Jin, Q. (2025) · Brain Sciences · doi:10.3390/brainsci15080812 · Cited by 9
Höfling, C., Shehabi, E., Kuhn, P., Lichtenthaler, S. F., Hartlage‐Rübsamen, M., & Roßner, S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00137 · Cited by 5
Biological Sex Disparities in Alzheimer’s Disease
Almutairi, J. A., & Kidd, E. J. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_545 · Cited by 4
Wang, M., Jin, B., Xu, J., & Wang, C. (2025) · Nutrients · doi:10.3390/nu17162679 · Cited by 4
Colacurcio, D. J., Zyskind, J. W., Jordan‐Sciutto, K. L., & Akay, C. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.10.031 · Cited by 4
Krick, K. E., Weekman, E. M., Johnson, S. N., Sudduth, T. L., Rogers, C. B., Nicolayson, E. J., Kleinhenz, M. T., & Wilcock, D. M. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107013 · Cited by 3
Unveiling FOXO3's metabolic contribution to menopause and Alzheimer's disease
O'Mahony, C., Hidalgo‐Lanussa, O., & Barreto, G. E. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112679 · Cited by 3
Boitet, M., Eun, H., Lee, T., Kim, J., & Grailhe, R. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02997-y · Cited by 3
Criscuolo, C., Chartampila, E., Ginsberg, S. D., & Scharfman, H. E. (2023) · eNeuro · doi:10.1523/eneuro.0192-23.2023 · Cited by 6
Ono, M., Ito, T., Yamaki, S., Hori, Y., Zhou, Q., Zhao, X., Muramoto, S., Yamamoto, R., Furuyama, T., Sakata‐Haga, H., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28821 · Cited by 3
Physiological factors could enhance amyloid-beta toxicity
Hunya, Á. G. (2013) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.1674 · Cited by 3
Gandy, S. (2004) · Human Pathology · doi:10.1016/j.humpath.2004.01.003 · Cited by 3
Zhao, D.-P., Lei, X., Wang, Y., Ao, X., Zhao, C.-Y., Xu, Y., Zhang, Y., Liu, G., Geng, F., Xu, H., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.971385 · Cited by 2
Species, Strain, and Gender Issues in the Development and Validation of Animal Models of Dementia
Dijck, A. V., Dam, D. V., & Deyn, P. P. D. (2010) · Neuromethods · doi:10.1007/978-1-60761-898-0_4 · Cited by 2
Sex differences in microglia as a risk factor for Alzheimer’s disease
Delage, C. I., Rendina, D. N., Malacon, K. E., Tremblay, M., & Bilbo, S. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819344-0.00008-9 · Cited by 2
Sex differences in the injured brain
Melcangi, R. C., & García‐Segura, L. M. (2011) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2011.112 · Cited by 1
Xu, Y., Yang, Y., Jiang, Y., Li, B., Xie, Y., Shi, Y., & Le, G. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116858 · Cited by 3
The Role of Apolipoprotein E Concentration and Isoform in Amyloid-beta Metabolism In Vivo
Castellano, J. M. (2011) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7416v3s
Amyloid precursor protein with the Alzheimer´s disease 670/671 mutation : Animal and cellular models
Kloskowska, E. (2008) · Figshare
Hvoslef‐Eide, M. (2012) · ORCA Online Research @Cardiff (Cardiff University)
Hall, K. (2011) · ORCA Online Research @Cardiff (Cardiff University)
Animal models of Alzheimer’s disease for preclinical research
Takahashi, H. (2010) · Folia Pharmacologica Japonica · doi:10.1254/fpj.136.6
Transgenic mouse models of Alzheimer's disease
Brooks, S. P., & Dunnett, S. B. (2005) · CRC Press eBooks · doi:10.1201/b13239-71
Klakotskaia, D. (2017) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/63858
Chow, H., Sun, J. K., Wu, D., Peng, A. Z., Wong, G. C., Hart, R. P., & Herrup, K. (2024) · Research Square · doi:10.21203/rs.3.rs-4489289/v1
Lapcinski, I. P., Petersen, A. J., Ashe, K. H., & Liu, P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.11.648457
Hanafy, A. S., Lamprecht, A., & Dietrich, D. (2023) · Figshare · doi:10.6084/m9.figshare.24628136
Morales, R., Duran-Aniotz, C. A., Bravo-Alegria, J. B., Estrada, L. D., Shahnawaz, M., Hu, P.-P., Kramm, C., Morales‐Scheihing, D., Urayama, A., & Soto, C. (2020) · Figshare · doi:10.6084/m9.figshare.13346964
Additional file 1 of Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice
Ruiz‐Riquelme, A., Mao, A., Barghash, M. M., Lau, H. H. C., Stuart, E., Kovacs, G. G., Nilsson, K. P. R., Fraser, P. E., Schmitt‐Ulms, G., & Watts, J. C. (2021) · Figshare · doi:10.6084/m9.figshare.14570473
Mitochondria, neurosteroids and biological rhythms : implications in health and disease states
Grimm, A. (2015) · theses.fr (ABES) · doi:10.70675/8aac5aa9z77cdz49bdz9cf5z0ff0b5dd0f84
Mao, A., Ruiz‐Riquelme, A., Barghash, M. M., Silver, N. R. G., Lau, H. H. C., Stuart, E., Zampar, S., Sehlin, D., Syvänen, S., Pollanen, M. S., et al. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02390-z
Zhang, X., Zhuang, D., Lai, C., Zheng, C., Soh, Z. D., Wagner, S. K., Cai, V. Y., Yang, Z., Wang, S., Geng, X., et al. (2026) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2026.101504
Impact of stroke on respiratory function and amyloid-β pathology in Tg-2576 mice
Zhang, Y., Hamamy, A. E., Iqbal, Z., Ranjan, A., Sumani, D., Souza, K. A. D., Lee, J., Marrelli, S. P., McCullough, L. D., & Li, J. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261476022
Marshall, J. P. S., Harutyunyan, A., Ng, J., West, O. M., Collins, J. M., King, A. E., Morizzi, J., Wright, P., Calkin, A. C., Drew, B. G., et al. (2026) · Journal of Neuroscience Research · doi:10.1002/jnr.70161
Metadata
- Authors
- Callahan, M. J., Lipinski, W. J., Bian, F., Durham, R. A., Pack, A., & Walker, L. C.
- Affiliations
- Pfizer (United States) (US)
- Corresponding author
- Callahan, Michael J.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 158
- Issue
- 3
- Pages
- 1173-1177
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC1850367
- OpenAlex
- W2164192847
- Cited by
- 274
- References
- 30
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 5 · 2022: 8 · 2021: 14 · 2020: 10 · 2019: 14 · 2018: 9 · 2017: 10 · 2016: 9 · 2015: 17 · 2014: 15 · 2013: 16 · 2012: 10
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Tulane University
- York University
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid plaques, amyloid-beta, amyloid precursor protein, Tg2576 mice, sex differences, aging, Alzheimer's disease, amyloid deposition, hippocampus, neocortex, Aβ40, amyloid-beta 42
- MeSH terms
- Aging, Alzheimer Disease, Animals, Disease Models, Animal, Female, Hippocampus, Male, Mice, Transgenic, Peptide Fragments, Sex Factors, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Neocortex, Mice, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review