The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Widespread Nitration of Pathological Inclusions in Neurodegenerative Synucleinopathies
Open accessAbstract
Reactive nitrogen species may play a mechanistic role in neurodegenerative diseases by posttranslationally altering normal brain proteins. In support of this hypothesis, we demonstrate that an anti-3-nitrotyrosine polyclonal antibody stains all of the major hallmark lesions of synucleinopathies including Lewy bodies, Lewy neurites and neuraxonal spheroids in dementia with Lewy bodies, the Lewy body variant of Alzheimer's disease, and neurodegeneration with brain iron accumulation type 1, as well as glial and neuronal cytoplasmic inclusions in multiple system atrophy. This antibody predominantly recognized nitrated alpha-synuclein when compared to other in vitro nitrated constituents of these pathological lesions, such as neurofilament subunits and microtubules. Collectively, these findings imply that alpha-synuclein is nitrated in pathological lesions. The widespread presence of nitrated alpha-synuclein in diverse intracellular inclusions suggests that oxidation/nitration is involved in the onset and/or progression of neurodegenerative diseases.
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Self-citationMutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
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Cited by
Oxidative stress in Parkinson's disease
Jenner, P. (2003) · Annals of Neurology · doi:10.1002/ana.10483 · Cited by 2,053
the Arizona Parkinson’s Disease Consortium, Beach, T. G., Adler, C. H., Lue, L., Sue, L. I., Bachalakuri, J., Henry-Watson, J., Sasse, J., Boyer, S., Shirohi, S., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0538-8 · Cited by 698
Neuropathology, biochemistry, and biophysics of α‐synuclein aggregation
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Fauvet, B., Mbefo, M. K., Fares, M.-B., Desobry, C., Michael, S., Ardah, M. T., Tsika, E., Coune, P., Prudent, M., Lion, N., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.318949 · Cited by 566
Induction of α-Synuclein Aggregation by Intracellular Nitrative Insult
Paxinou, E., Chen, Q., Weisse, M., Giasson, B. I., Norris, E. H., Rueter, S. M., Trojanowski, J. Q., Lee, V. M.-Y., & Ischiropoulos, H. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08053.2001 · Cited by 440
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Metadata
- Authors
- Duda, J. E., Giasson, B. I., Chen, Q., Gur, T. L., Hurtig, H. I., Stern, M. B., Gollomp, S. M., Ischiropoulos, H., Lee, V. M.-Y., & Trojanowski, J. Q.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2000-11
- Volume
- 157
- Issue
- 5
- Pages
- 1439-1445
- ISSN
- 0002-9440 (ISSN-L)
- OpenAlex
- W2025145394
- Cited by
- 277
- References
- 58
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Duda, J. E., Giasson, B. I., Chen, Q., Gur, T. L., Hurtig, H. I., Stern, M. B., Gollomp, S. M., Ischiropoulos, H., Lee, V. M.-Y., & Trojanowski, J. Q. (2000). Widespread Nitration of Pathological Inclusions in Neurodegenerative Synucleinopathies. The American Journal of Pathology. https://doi.org/10.1016/s0002-9440(10)64781-5
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