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Electrospray ionization of large multiply charged species proceeds via Dole’s charged residue mechanism
Open accessAbstract
The maximum charge zmax on a variety of electrospray ions of globular proteins retaining their native structure, as well as naturally compact starburst dendrimers is compared to the Rayleigh charge zR (based on a water sphere with the ion mass). For most published data examined, zmax is between 65% and 110% of zR, providing strong support in favor of Dole’s charged residue mechanism, at least for masses from 3.3 kD up to 1.4 MD. Other large but less compact ions from proteins and linear chains of polyethylene glycols (PEGs) have zmax values considerably larger than zR, apparently implying that they also form as charged residues, though from non-spherical drops held together by the polymer backbone.
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Citations
Cited by
Electrospray: From ions in solution to ions in the gas phase, what we know now
Kebarle, P., & Verkerk, U. H. (2009) · Mass Spectrometry Reviews · doi:10.1002/mas.20247 · Cited by 905
Native Mass Spectrometry: What is in the Name?
Leney, A. C., & Heck, A. J. R. (2017) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-016-1545-3 · Cited by 602
“This observation was rationalized by the fact that during the ESI process, assuming the charge residue model [60], only solvent exposed basic residues could pick up a charge/proton.”
MethodKonermann, L. (2017) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-017-1739-3 · Cited by 243
Resolving Adeno-Associated Viral Particle Diversity With Charge Detection Mass Spectrometry
Pierson, E. E., Keifer, D. Z., Asokan, A., & Jarrold, M. F. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b00883 · Cited by 152
Hedges, J. B., Vahidi, S., Yue, X., & Konermann, L. (2013) · Analytical Chemistry · doi:10.1021/ac401020s · Cited by 109
Metadata
- Authors
- Fernandez de la Mora, J.
- Venue
- Analytica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 406
- Issue
- 1
- Pages
- 93-104
- ISSN
- 0003-2670 (ISSN-L)
- OpenAlex
- W2165192566
- Cited by
- 528
- References
- 0
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Fernandez de la Mora, J. (2000). Electrospray ionization of large multiply charged species proceeds via Dole’s charged residue mechanism. Analytica Chimica Acta. https://doi.org/10.1016/s0003-2670(99)00601-7
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