The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Apoptosis in neurodegenerative diseases: the role of mitochondria
Open accessAbstract
Nerve cell death is the central feature of the human neurodegenerative diseases. It has long been thought that nerve cell death in these disorders occurs by way of necrosis, a process characterized by massive transmembrane ion currents, compromise of mitochondrial ATP production, and the formation of high levels of reactive oxygen species combining to induce rapid disruption of organelles, cell swelling, and plasma membrane rupture with a secondary inflammatory response. Nuclear DNA is relatively preserved. Recent evidence now indicates that the process of apoptosis rather than necrosis primarily contributes to nerve cell death in neurodegeneration. This has opened up new avenues for understanding the pathogenesis of neurodegeneration and may lead to new and more effective therapeutic approaches to these diseases.
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Mitochondrial Complex I Deficiency in Parkinson's Disease
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Mitochondrial defect in Huntington's disease caudate nucleus
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Cybrids in Alzheimer's disease: a cellular model of the disease?
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Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain
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Flavonoids: antioxidants or signalling molecules?
Williams, R. J., Spencer, J. P. E., & Rice-Evans, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.001 · Cited by 2,016
The axonal transport of mitochondria
Hollenbeck, P. J., & Saxton, W. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02745 · Cited by 771
Mitochondria as a Pharmacological Target
Szewczyk, A., & Wojtczak, L. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.101 · Cited by 538
VDAC1, mitochondrial dysfunction, and Alzheimer’s disease
Shoshan-Barmatz, V., Nahon-Crystal, E., Shteinfer-Kuzmine, A., & Gupta, R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.010 · Cited by 286
A Possible Site of Superoxide Generation in the Complex I Segment of Rat Heart Mitochondria
Ohnishi, S. T., Ohnishi, T., Muranaka, S., Fujita, H., Kimura, H., Uemura, K., Yoshida, K.-I., & Utsumi, K. (2005) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-005-4117-y · Cited by 123
Metadata
- Authors
- Tatton, W. G., & Olanow, C. W.
- Venue
- Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Publisher
- Elsevier BV
- Published
- 1999-02
- Volume
- 1410
- Issue
- 2
- Pages
- 195-213
- ISSN
- 0005-2728 (ISSN-L)
- OpenAlex
- W2044031210
- Cited by
- 257
- References
- 9
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tatton, W. G., & Olanow, C. W. (1999). Apoptosis in neurodegenerative diseases: the role of mitochondria. Biochimica et Biophysica Acta (BBA) - Bioenergetics. https://doi.org/10.1016/s0005-2728(98)00167-4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
