Flavonoids: antioxidants or signalling molecules?

Structure-antioxidant activity relationships of flavonoids and phenolic acids

Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085 · see citing works

Mitochondria and Apoptosis

Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,998 · see citing works

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689 · see citing works

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,290 · see citing works

Signal transduction by the JNK group of MAP kinases

Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237 · see citing works

Cellular survival: a play in three Akts

Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216 · see citing works

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

Vlahos, C. J., Matter, W. F., Hui, K. Y., & Brown, R. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37680-9 · Cited by 3,248 · see citing works

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

Zha, J., Harada, H., Yang, E., Jockel, J., & Korsmeyer, S. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81382-3 · Cited by 2,578 · see citing works

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

del Peso, L., González‐García, M., Page, C., Herrera, R., & Núñez, G. (1997) · Science · doi:10.1126/science.278.5338.687 · Cited by 2,213 · see citing works

Neurotrophin signal transduction in the nervous system

Kaplan, D. R., & Miller, F. D. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00092-1 · Cited by 1,944 · see citing works

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,887 · see citing works

Apoptosis in the nervous system

Yuan, J., & Yankner, B. A. (2000) · Nature · doi:10.1038/35037739 · Cited by 1,862 · see citing works

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Walker, E. H., Pacold, M. E., Perišić, O., Stephens, L., Hawkins, P. T., Wymann, M. P., & Williams, R. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00089-4 · Cited by 1,211 · see citing works

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.Preprint

Kennedy, S. G., Wagner, A. J., Conzen, S. D., Jordán, J., Bellacosa, A., Tsichlis, P. N., & Hay, N. (1997) · Genes & Development · doi:10.1101/gad.11.6.701 · Cited by 1,074 · see citing works

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

Coffer, P. J., Jin, J., & Woodgett, J. R. (1998) · Biochemical Journal · doi:10.1042/bj3350001 · Cited by 1,067 · see citing works

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

Srinivasula, S. M., Hegde, R. P., Saleh, A., Datta, P., Shiozaki, E. N., Chai, J., Lee, R., Robbins, P. D., Fernandes‐Alnemri, T., Shi, Y., et al. (2001) · Nature · doi:10.1038/35065125 · Cited by 1,013 · see citing works

Mitochondrial permeability transition: a common pathway to necrosis and apoptosis

Js, K., He, L., & Lemasters, J. J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00618-1 · Cited by 756 · see citing works

Flavonoid Antioxidants

Rice-Evans, C. A. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013373011 · Cited by 719 · see citing works

Flavonoids in Health and Disease

Rice-Evans, C. A., & Packer, L. (2003) · CRC Press eBooks · doi:10.1201/9780367803681 · Cited by 691 · see citing works

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

Behrens, A., Sibilia, M. C., & Wagner, E. F. (1999) · Nature Genetics · doi:10.1038/6854 · Cited by 676 · see citing works

Redox Control of Cell Death

Ueda, S., Masutani, H., Nakamura, H., Tanaka, T., Ueno, M., & Yodoi, J. (2002) · Antioxidants and Redox Signaling · doi:10.1089/15230860260196209 · Cited by 581 · see citing works

Redox signaling and the MAP kinase pathways

Torres, M., & Forman, H. J. (2003) · BioFactors · doi:10.1002/biof.5520170128 · Cited by 580 · see citing works

Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons

Crowder, R. J., & Freeman, R. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02933.1998 · Cited by 575 · see citing works

Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation

Uchida, K., Shiraishi, M., Naito, Y., Torii, Y., Nakamura, Y., & Osawa, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2234 · Cited by 569 · see citing works

Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition

Agullo, G., Gamet‐Payrastre, L., Manenti, S., Viala, C., Rémésy, C., Chap, H., & Payrastre, B. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)82453-7 · Cited by 535 · see citing works

The c-Jun transcription factor – bipotential mediator of neuronal death, survival and regeneration

Herdegen, T., Skene, J. H. P., & Bähr, M. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01000-4 · Cited by 524 · see citing works

Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product

Metodiewa, D., Jaiswal, A. K., Čėnas, N., Dičkancaitė, E., & Segura‐Aguilar, J. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00167-1 · Cited by 515 · see citing works

The gastrointestinal tract: A major site of antioxidant action?

Halliwell, B. B., Zhao, K., & Whiteman, M. (2000) · Free Radical Research · doi:10.1080/10715760000301341 · Cited by 514 · see citing works

JNK and p38 stresskinases — degenerative effectors of signal-transduction-cascades in the nervous system

Mielke, K., & Herdegen, T. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00042-8 · Cited by 489 · see citing works

Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices

So, F. V., Guthrie, N., Chambers, A. F., Moussa, M., & Carroll, K. K. (1996) · Nutrition and Cancer · doi:10.1080/01635589609514473 · Cited by 488 · see citing works

Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells

Wang, I., Lin‐Shiau, S., & Lin, J. (1999) · European Journal of Cancer · doi:10.1016/s0959-8049(99)00168-9 · Cited by 462 · see citing works

Protein kinase C inhibition by plant flavonoids

Ferriola, P. C., Cody, V., & Middleton, E. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90309-2 · Cited by 454 · see citing works

Antioxidants and oxidants regulated signal transduction pathways

Owuor, E. D., & Kong, A. T. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01137-1 · Cited by 439 · see citing works

Involvement of Protein Kinase C Activation and Cell Survival/ Cell Cycle Genes in Green Tea Polyphenol (−)-Epigallocatechin 3-Gallate Neuroprotective Action

Levites, Y., Amit, T., Youdim, M. B. H., & Mandel, S. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202832200 · Cited by 417 · see citing works

The small intestine can both absorb and glucuronidate luminal flavonoids

Spencer, J. P. E., Chowrimootoo, G., Choudhury, R., Debnam, E. S., Srai, S. K., & Rice-Evans, C. A. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01160-6 · Cited by 405 · see citing works

Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death

Chen, C., Yu, R., Owuor, E. D., & Kong, A.-N. T. (2000) · Archives of Pharmacal Research · doi:10.1007/bf02975249 · Cited by 403 · see citing works

Flavonoids: A class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

Conseil, G., Baubichon-Cortay, H., Dayan, G., Jault, J., Barron, D., & Pietro, A. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9831 · Cited by 382 · see citing works

Role of Mitochondrial Inner Membrane Permeabilization in Necrotic Cell Death, Apoptosis, and Autophagy

Lemasters, J. J., Qian, T., He, L., Kim, J.-S., Elmore, S. P., Cascio, W. E., & Brenner, D. A. (2002) · Antioxidants & Redox Signaling · doi:10.1089/152308602760598918 · Cited by 377 · see citing works

Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3

Schroeter, H., Spencer, J. P. E., Rice-Evans, C. A., & WILLIAMS, R. J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3580547 · Cited by 373 · see citing works

Uptake and metabolism of epicatechin and its access to the brain after oral ingestion

Mohsen, M. M. A. E., Kuhnle, G., Rechner, A. R., Schroeter, H., Rose, S., Jenner, P. G., & Rice-Evans, C. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01137-1 · Cited by 369 · see citing works

Induction of apoptosis by quercetin: involvement of heat shock protein.

Wei, Y., Zhao, X., Kariya, Y., Fukata, H., Teshigawara, K., & Uchida, A. (1994) · PubMed · Cited by 356 · see citing works

Modulation of Pro-survival Akt/Protein Kinase B and ERK1/2 Signaling Cascades by Quercetin and Its in Vivo Metabolites Underlie Their Action on Neuronal Viability

Spencer, J. P. E., Rice-Evans, C. A., & Williams, R. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305063200 · Cited by 350 · see citing works

A Role for the PI-3 Kinase Signaling Pathway in Fear Conditioning and Synaptic Plasticity in the Amygdala

Lin, C.-H., Yeh, S.-H., Lin, C.-H., Lu, K., Leu, T., Chang, W., & Gean, P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00433-0 · Cited by 342 · see citing works

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Schroeter, H., BOYD, C., SPENCER, J., WILLIAMS, R., Cadenas, E., & Rice-Evans, C. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00075-1 · Cited by 338 · see citing works

Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells

Kuo, S. (1996) · Cancer Letters · doi:10.1016/s0304-3835(96)04458-8 · Cited by 320 · see citing works

Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines.

Masuda, M., Suzui, M., & Weinstein, I. B. (2001) · PubMed · Cited by 318 · see citing works

Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity

Spencer, J. P. E., Mohsen, M. M. A. E., & Rice-Evans, C. A. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.11.010 · Cited by 317 · see citing works

Neurotrophin signalling pathways regulating neuronal apoptosis

Miller, F. D., & Kaplan, D. R. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000919 · Cited by 317 · see citing works

Dopamine Induces Apoptosis through an Oxidation-involved SAPK/JNK Activation Pathway

Luo, Y., Umegaki, H., Wang, X., Abe, R., & Roth, G. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3756 · Cited by 310 · see citing works

Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression.

Gerritsen, M. E., Carley, W. W., Ranges, G. E., Shen, C. P., Phan, S. A., Ligon, G. F., & Perry, C. A. (1995) · Europe PMC (PubMed Central) · Cited by 307 · see citing works

HNE interacts directly with JNK isoforms in human hepatic stellate cells.

Parola, M., Robino, G., Marra, F., Pinzani, M., Bellomo, G., Leonarduzzi, G., Chiarugi, P., Camandola, S., Poli, G., Waeg, G., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1413 · Cited by 297 · see citing works

Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.

Enslen, H., Tokumitsu, H., Stork, P. A., Davis, R. J., & Soderling, T. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10803 · Cited by 289 · see citing works

Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis‐associated properties in A431 cells overexpressing epidermal growth factor receptor

Huang, Y. ‐., Hwang, J. ‐., Lee, P.-P. H., Ke, F. ‐., Huang, J. ‐., Huang, C. ‐., Kandaswami, C. C., Middleton, E., & Lee, M. ‐. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702879 · Cited by 287 · see citing works

Inhibition of UVB-Induced Oxidative Stress-Mediated Phosphorylation of Mitogen-Activated Protein Kinase Signaling Pathways in Cultured Human Epidermal Keratinocytes by Green Tea Polyphenol (−)-Epigallocatechin-3-gallate

Katiyar, S. K., Afaq, F., Azizuddin, K., & Mukhtar, H. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9276 · Cited by 272 · see citing works

Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis

Kong, A. T., Yu, R., Chen, C., Mandlekar, S., & Primiano, T. (2000) · Archives of Pharmacal Research · doi:10.1007/bf02976458 · Cited by 270 · see citing works

Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved.

Chung, J. Y., Huang, C., Meng, X., Dong, Z., & Yang, C. S. (1999) · PubMed · Cited by 262 · see citing works

Apoptosis in neurodegenerative diseases: the role of mitochondria

Tatton, W. G., & Olanow, C. W. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00167-4 · Cited by 255 · see citing works

Flavonoids and the inhibition of PKC and PI 3-kinase

Gamet‐Payrastre, L., Manenti, S., Gratacap, M., Tulliez, J. E., Chap, H., & Payrastre, B. (1999) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(98)00220-1 · Cited by 255 · see citing works

Cell Death Inhibition

Goyal, L. (2001) · Cell · doi:10.1016/s0092-8674(01)00276-8 · Cited by 253 · see citing works

A Role for MAPK/ERK in Sympathetic Neuron Survival: Protection against a p53-Dependent, JNK-Independent Induction of Apoptosis by Cytosine Arabinoside

Anderson, C. N. G., & Tolkovsky, A. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00664.1999 · Cited by 246 · see citing works

Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites

Spencer, J. P. E., Kuhnle, G., WILLIAMS, R. J., & Rice-Evans, C. A. (2003) · Biochemical Journal · doi:10.1042/bj20021972 · Cited by 241 · see citing works

Inhibition of ultraviolet B-mediated activation of nuclear factor κB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate

Afaq, F., Adhami, V. M., Ahmad, N., & Mukhtar, H. (2003) · Oncogene · doi:10.1038/sj.onc.1206206 · Cited by 236 · see citing works

Epigallocatechin‐3‐gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR‐related pathways of signal transduction

Masuda, M., Suzui, M., Lim, J. T. E., Deguchi, A., Soh, J., & Weinstein, I. B. (2002) · Journal of Experimental Therapeutics and Oncology · doi:10.1046/j.1359-4117.2002.01062.x · Cited by 235 · see citing works

Anti-apoptotic effect of quercetin: Intervention in the JNK- and ERK-mediated apoptotic pathways

Ishikawa, Y., & Kitamura, M. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00265.x · Cited by 221 · see citing works

Selected Novel Flavones Inhibit the DNA Binding or the DNA Religation Step of Eukaryotic Topoisomerase I

Boege, F., Straub, T., Kehr, A., Boesenberg, C., Christiansen, K., Andersen, A. H., Jakob, F. J., & Köhrle, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.4.2262 · Cited by 220 · see citing works

Overview—Flavonoids: A New Family of Benzodiazepine Receptor Ligands

Medina, J. H., Viola, H., Wolfman, C., Marder, M., Wasowski, C., Calvo, D. J., & Paladini, A. C. (1997) · Neurochemical Research · doi:10.1023/a:1027303609517 · Cited by 218 · see citing works

Myricetin and quercetin, the flavonoid constituents ofGinkgo biloba extract, greatly reduce oxidative metabolism in both resting and Ca2+-loaded brain neurons

Oyama, Y., Fuchs, P. A., Katayama, N., & Noda, K. (1994) · Brain Research · doi:10.1016/0006-8993(94)91431-1 · Cited by 209 · see citing works

Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells.

Pianetti, S., Guo, S., Kavanagh, K. T., & Sonenshein, G. E. (2002) · PubMed · Cited by 207 · see citing works

Plant polyphenols: free radical scavengers or chain-breaking antioxidants?

Rice-Evans, C. A. (1995) · Biochemical Society Symposia · doi:10.1042/bss0610103 · Cited by 204 · see citing works

Hydrogen peroxide‐mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: dependence on Ca2+ and PI3‐kinase

Crossthwaite, A. J., Hasan, S., & Williams, R. J. (2001) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00637.x · Cited by 201 · see citing works

The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs

Matter, W. F., Brown, R. F., & Vlahos, C. J. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90792-j · Cited by 200 · see citing works

Ca2+-Permeable AMPA Receptors Induce Phosphorylation of cAMP Response Element-Binding Protein through a Phosphatidylinositol 3-Kinase-Dependent Stimulation of the Mitogen-Activated Protein Kinase Signaling Cascade in Neurons

Perkinton, M. S., Sihra, T. S., & Williams, R. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05861.1999 · Cited by 198 · see citing works

Antioxidant capacity of flavanols and gallate esters: pulse radiolysis studies

Bors, W., & Michel, C. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00187-2 · Cited by 197 · see citing works

Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway

Kobuchi, H., Roy, S., Sen, C. K., Nguyen, H. G., & Packer, L. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.3.c403 · Cited by 197 · see citing works

Epicatechin and its in vivo metabolite, 3′-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation

Spencer, J. P. E., Schroeter, H., Kuhnle, G., Srai, S. K., Tyrrell, R. M., Hahn, U., & Rice-Evans, C. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3540493 · Cited by 194 · see citing works

CEP‐1347 (KT7515), an Inhibitor of JNK Activation, Rescues Sympathetic Neurons and Neuronally Differentiated PC12 Cells from Death Evoked by three Distinct Insults

Maroney, A. C., Finn, J. P., Bozyczko‐Coyne, D., O’Kane, T. M., Neff, N. T., Tolkovsky, A. M., Park, D. S., Yan, C. Y. I., Troy, C. M., & Greene, L. A. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.01901.x · Cited by 190 · see citing works

Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein

Schroeter, H., Williams, R. J., Matin, R., Iversen, L. L., & Rice-Evans, C. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00415-9 · Cited by 184 · see citing works

The Lipid Peroxidation Product 4‐Hydroxy‐2,3‐Nonenal Increases AP‐1‐Binding Activity Through Caspase Activation in Neurons

Camandola, S., Poli, G., & Mattson, M. P. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740159.x · Cited by 177 · see citing works

Epigallocathechin-3 Gallate Selectively Inhibits the PDGF-BB–induced Intracellular Signaling Transduction Pathway in Vascular Smooth Muscle Cells and Inhibits Transformation ofsis-transfected NIH 3T3 Fibroblasts and Human Glioblastoma Cells (A172)

Ahn, H. Y., Hadizadeh, K. R., Seul, C., Yun, Y., Vetter, H., & Sachinidis, A. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.4.1093 · Cited by 173 · see citing works

A novel antioxidant flavonoid (IdB 1031) affecting molecular mechanisms of cellular activation

Ursini, F., Maiorino, M., Morazzoni, P., Roveri, A., & PIFFERI, G. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90054-x · Cited by 168 · see citing works

Quercetin metabolites inhibit copper ion‐induced lipid peroxidation in rat plasma1

da Silva, E. L., Piskuła, M. K., Yamamoto, N., Moon, J., & Terao, J. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00709-1 · Cited by 167 · see citing works

The JNK and P38 MAP kinase signaling pathways in T cell–mediated immune responses44This team of investigators has contributed extensively to the field of MAP kinase signal transduction in thymocyte and T cell differentiation.

Rincón, M., Flavell, R. A., & Davis, R. J. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00219-7 · Cited by 167 · see citing works

Molecular mechanisms in the antiproliferative action of quercetin

Csókay, B., Prajda, N., Weber, G., & Oláh, E. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00230-0 · Cited by 162 · see citing works

Bioavailability of Flavan-3-ols and Procyanidins: Gastrointestinal Tract Influences and Their Relevance to Bioactive Forms In Vivo

Spencer, J. P. E., Schroeter, H., Rechner, A. R., & Rice-Evans, C. A. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601317203558 · Cited by 161 · see citing works

Structure-activity relationships governing antioxidant capacities of plant polyphenols

Bors, W., Michel, C., & Stettmaier, K. (2001) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(01)35241-2 · Cited by 160 · see citing works

Mechanisms of inhibition of the Ras‐MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (‐)‐epigallocatechin‐3‐gallate and theaflavin‐3,3′‐digallate 1

Chung, J. Y., Park, J. O., Phyu, H., Dong, Z., & Yang, C. S. (2001) · The FASEB Journal · doi:10.1096/fj.01-0031fje · Cited by 160 · see citing works

Identification and Antioxidant Activity of Flavonoid Metabolites in Plasma and Urine of Eriocitrin-Treated Rats

Miyake, Y., Shimoi, K., Kumazawa, S., Yamamoto, K., Kinae, N., & Osawa, T. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990994g · Cited by 154 · see citing works

Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts

Spencer, J. P. E., Schroeter, H., Crossthwaithe, A. J., Kuhnle, G., Williams, R. J., & Rice-Evans, C. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00704-3 · Cited by 154 · see citing works

Epigallocatechin-3-gallate inhibits activation of HER-2/neu and downstream signaling pathways in human head and neck and breast carcinoma cells.

Masuda, M., Suzui, M., Lim, J. T. E., & Weinstein, I. B. (2003) · PubMed · Cited by 154 · see citing works

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