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Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a β3-adrenoceptor agonist
Abstract
In a previous study, we demonstrated that chronic treatment with a new beta3-adrenoceptor agonist, CL 316,243 [disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-ben zodioxazole-2,2-dicarboxylate], promoted thermogenesis, caused the appearance of multilocular adipocytes in white adipose tissue (WAT), and retarded development of obesity in young rats eating a high-fat diet (Himms-Hagen et al., Am J Physiol 266: R1371-R1382, 1994). Objectives of the present study were to find out whether CL 316,243 could reverse established diet-induced obesity in rats and to identify the multilocular adipocytes that appeared in WAT. Infusion of CL 316,243 (1 mg/kg/day) reduced abdominal fat, with a decrease in enlarged adipocyte size but no loss of white adipocytes. The resting metabolic rate increased by 40-45%, but food intake was not altered. Abundant densely stained multilocular brown adipocytes expressing uncoupling protein (UCP) appeared in retroperitoneal WAT, in which a marked increase in protein content occurred. UCP content of interscapular brown adipose tissue (BAT) was also increased markedly. We suggest that the substantial increase in the resting metabolic rate induced by CL 316,243 occurs in brown adipocytes in both BAT and WAT. The origin of the brown adipocytes that appeared in WAT is uncertain. They may have been small brown preadipocytes, expressing beta3-adrenoceptors but with few mitochondria and little or no UCP, that were induced to hypertrophy by the beta3-agonist.
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“Induction of BAT in mice promotes energy expenditure, reduces adiposity, and protects mice from diet-induced obesity 73,74.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [73]
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Cites
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,645
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,857
Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90194-9 · Cited by 2,028
Methods for the determination of adipose cell size in man and animals
Hirsch, J., & Gallian, E. (1968) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43151-7 · Cited by 894
Cousin, B., Cinti, S., Morroni, M., Raimbault, S., Ricquier, D., Pénicaud, L., & Casteilla, L. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.4.931 · Cited by 665
Bray, G. A., & Bouchard, C. (1997) · CRC Press eBooks · Cited by 618
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1995) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(95)80025-5 · Cited by 462
Himms‐Hagen, J., Cui, J. Z., Danforth, E., Taatjes, D. J., Lang, S. S., Waters, B. L., & Claus, T. H. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.4.r1371 · Cited by 382
Self-citationBrown adipose tissue in the parametrial fat pad of the mouse
Young, P., Arch, J. R. S., & Ashwell, M. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)80822-4 · Cited by 377
Mantzoros, C. S., Frederich, R. C., Flier, J. S., Qu, D., Susulic, V. S., Lowell, B. B., & Maratos–Flier, E. (1996) · Diabetes · doi:10.2337/diab.45.7.909 · Cited by 314
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Wu, C., Cheng, W., Xing, H., Dang, Y., Li, F., & Zhu, Z. (2011) · BioMed Research International · doi:10.1155/2011/159834 · Cited by 26
PACAP is essential for the adaptive thermogenic response of brown adipose tissue to cold exposure
Diané, A., Nikolic, N., Rudecki, A. P., King, S. M., Bowie, D. J., & Gray, S. L. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0316 · Cited by 27
Molecular pathways regulating the formation of brown‐like adipocytes in white adipose tissue
Fu, J., Li, Z., Zhang, H., Mao, Y., Wang, A., Wang, X., Zou, Z., & Zhang, X. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2600 · Cited by 29
Brown adipose tissue: the molecular mechanism of its formation
Wolf, G. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00184.x · Cited by 26
Role of BMP7 in appetite regulation, adipogenesis, and energy expenditure
Saini, S., Duraisamy, A. J., Bayen, S., Vats, P., & Singh, S. B. (2014) · Endocrine · doi:10.1007/s12020-014-0406-8 · Cited by 28
Al–Massadi, O., Porteiro, B., Kuhlow, D., Köhler, M., Gonzalez-Rellan, M. J., García-Lavandeira, M., Díaz‐Rodriguez, E., Quiñones, M., Senra, A., Álvarez, C. V., et al. (2016) · Endocrinology · doi:10.1210/en.2016-1209 · Cited by 25
Cinti, S. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-370-7_1 · Cited by 31
Translational Pharmacology and Physiology of Brown Adipose Tissue in Human Disease and Treatment
Larson, C. J. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_184 · Cited by 26
Identification of a rhodanine derivative BML-260 as a potent stimulator of UCP1 expression
Feng, Z., Wei, Y., Zhang, Y., Qiu, Y., Liu, X., Su, L., Liang, N., Yin, H., & Ding, Q. (2019) · Theranostics · doi:10.7150/thno.31951 · Cited by 25
Seeking the source of adipocytes in adult white adipose tissues
Lee, Y., & Granneman, J. G. (2012) · Adipocyte · doi:10.4161/adip.20804 · Cited by 28
Milagro, F. I., & Martínez, J. A. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001774534 · Cited by 25
Reducing Effect of Feeding Powdered Scallop Shell on the Body Fat Mass of Rats
Yun Chun, L. I. U., & Hasegawa, Y. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70.86 · Cited by 23
Gaertner, F. C., Wiedemann, T., Yousefi, B. H., Lee, M., Repokis, I., Higuchi, T., Nekolla, S. G., Yu, M. Z., Robinson, S. P., Schwaiger, M., et al. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.119966 · Cited by 22
Wu, R., Yu, W., Fu, L., Li, F., Jing, J., Cui, X., Wang, S., Cao, Q., Xue, B., & Shi, H. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00292.2019 · Cited by 22
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Fujimoto, Y., Hashimoto, O., Shindo, D., Sugiyama, M., Tomonaga, S., Murakami, M., Matsui, T., & Funaba, M. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27443 · Cited by 20
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Wang, X., Zhao, Y., Zhou, D., Tian, Y., Feng, G., & Lu, Z. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03519-9 · Cited by 19
Pardo, R., Blasco, N., Vilà, M., Beiroa, D., Nogueiras, R., Cañas, X., Simó, R., Sanchı́s, D., & Villena, J. A. (2016) · Endocrinology · doi:10.1210/en.2015-1334 · Cited by 19
Hojná, S., Jordan, M. D., Kollias, H., & Pausová, Z. (2011) · Hypertension Research · doi:10.1038/hr.2011.188 · Cited by 19
Green, C. L., Mitchell, S. E., Derous, D., Wang, Y., Chen, L., Han, J. J., Promislow, D., Lusseau, D., Douglas, A., & Speakman, J. R. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz023 · Cited by 18
Boqué, N., n, J. C. O., Milagro, F. I., Moreno-Aliaga, M. J., & Martinez, J. E. A. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.1462 · Cited by 18
The thermogenic circuit: Regulators of thermogenic competency and differentiation
Lynes, M. D., & Tseng, Y. (2015) · Genes & Diseases · doi:10.1016/j.gendis.2015.03.001 · Cited by 18
Sibutramine-dependent brown fat activation in rats: an immunohistochemical study
Giordano, A., Centemeri, C., Zingaretti, M. C., & Cinti, S. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801926 · Cited by 17
Expression of human β3-adrenergic receptor induces adipocyte-like features in CHO/K1 fibroblasts
Gros, J., Gerhardt, C. C., & Strosberg, A. D. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.21.3791 · Cited by 17
Phytanic acid activates PPARα to promote beige adipogenic differentiation of preadipocytes
Wang, H., Mao, X., & Du, . (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.02.013 · Cited by 16
Hatakeyama, Y., Sakata, Y., Takakura, S., Manda, T., & Mutoh, S. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00131.2004 · Cited by 16
Snyder, P. B. (1999) · Emerging Therapeutic Targets · doi:10.1517/14728222.3.4.587 · Cited by 16
Ghorbani, M., Teimourian, S., Farzad, R., & Asl, N. N. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s73891 · Cited by 15
Self-citationOkamoto, Y., Higashiyama, H., Inoue, H., Kanematsu, M., Kinoshita, M., & Asano, S. (2007) · Pathology International · doi:10.1111/j.1440-1827.2007.02109.x · Cited by 15
Physiological regulation and metabolic role of browning in white adipose tissue
Janković, A., Otašević, V., Stančić, A., Buzadžić, B., Korać, A., & Korać, B. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0034 · Cited by 14
Faber, C., Zhu, Z. J., Castellino, S., Wagner, D. S., Brown, R. H., Peterson, R. A., Gates, L. D., Barton, J. C., Bickett, M., Hagerty, L., et al. (2014) · Journal of Applied Toxicology · doi:10.1002/jat.3030 · Cited by 15
Resistance and tolerance defenses in cancer: Lessons from infectious diseases
Rao, S., & Ayres, J. S. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.08.004 · Cited by 14
Milagro, F. I., Gómez‐Ambrosi, J., Forga, L., & Martínez, J. A. (1999) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.1999.00019.x · Cited by 14
The Adipose Organ: Morphological Perspectives of Adipose Tissues
Smorlesi, A., Frontini, A., & Cinti, S. (2014) · Springer eBooks · doi:10.1007/978-3-642-45207-9_8 · Cited by 14
Yun Chun, L. I. U., SATOH, K., & Hasegawa, Y. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.60349 · Cited by 13
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Brown adipose tissue human biomarkers: Which one fits best? A narrative review
Alito, A., Quartarone, A., Leonardi, G., Tisano, A., Bruschetta, A., Cucinotta, F., Milardi, D., & Portaro, S. (2022) · Medicine · doi:10.1097/md.0000000000032181 · Cited by 15
Sánchez‐Margalet, V., González-Yanes, C., Najib, S., & Santos‐Álvarez, J. (2010) · Regulatory Peptides · doi:10.1016/j.regpep.2010.10.004 · Cited by 12
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OMACHI, A., Ishioka, K., Uozumi, A., Kamikawa, A., Toda, C., Kimura, K., & Saito, M. (2006) · Research in Veterinary Science · doi:10.1016/j.rvsc.2006.10.003 · Cited by 12
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Yuliana, N. D., Korthout, H. A. A. J., Wijaya, C. H., Kim, H. K., & Verpoorte, R. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.586739 · Cited by 12
Pasha, A., Vignoli, M., Subbiani, A., Nocentini, A., Selleri, S., Gratteri, P., Dabraio, A., Casini, T., Filippi, L., Fotzi, I., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092149 · Cited by 13
Sankina, P., Lal, R., Khare, P., von Hörsten, S., Fester, L., Aggarwal, V., Zimmermann, K., & Bishnoi, M. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15781 · Cited by 11
Fatty Acids Rescue the Thermogenic Function of Sympathetically Denervated Brown Fat
Cao, Q., Wang, S., Wang, H., Cui, X., Jing, J., Yu, L., Shi, H., & Xue, B. (2021) · Biomolecules · doi:10.3390/biom11101428 · Cited by 10
Jeon, Y., Choi, J., Jang, E.-H., Seong, J. K., & Lee, K. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00821-6 · Cited by 11
Identification and genetic effect of haplotype in the bovine BMP7 gene
Huang, Y., Wang, X.-L., He, H., Lan, X., Lei, C., Zhang, C., & Chen, H. (2013) · Gene · doi:10.1016/j.gene.2013.03.009 · Cited by 11
Role of uncoupling protein 1 in the anti-obesity effect of β3-adrenergic agonist in the dog
OMACHI, A., Matsushita, Y., Kimura, K., & Saito, M. (2008) · Research in Veterinary Science · doi:10.1016/j.rvsc.2007.11.003 · Cited by 11
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Škop, V., Malínská, H., Trnovská, J., Hüttl, M., Cahová, M., Błachnio-Zabielska, A. U., Baranowski, M., Burian, M., Oliyarnyk, O., & Kazdová, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122768 · Cited by 10
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Wang, Z., Hou, Y., Ren, S., Liu, Z., Zuo, Z., Huang, S., Wang, W., Wang, H., Chen, Y., Xu, Y., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.01.043 · Cited by 8
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Tuong, Z. K., Fitzsimmons, R. L., Wang, S.-C., Oh, T. G., Lau, P., Steyn, F. J., Thomas, G. P., & Muscat, G. E. O. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.08.027 · Cited by 6
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Wang, N., Lu, H., Li, X., Du, Y., Meng, W., Ding, H., & Zhao, Q. (2019) · Lipids · doi:10.1002/lipd.12148 · Cited by 4
Vogel, H. G. (2007) · Springer eBooks · doi:10.1007/978-3-540-70995-4_13 · Cited by 4
Okamatsu‐Ogura, Y., Uozumi, A., Kitao, N., Kimura, K., & Saito, M. (2007) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2006.11.002 · Cited by 4
Yang, H., Zheng, P., Hu, J., Lin, Z., Sriboonvorakul, N., & Lin, S. (2024) · Foods · doi:10.3390/foods13233943 · Cited by 3
Brown and Beige Fat: Therapeutic Potential in Obesity
Meiliana, A., & Wijaya, A. (2014) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v6i2.32 · Cited by 3
Targeting Thermogenesis in the Development of Antiobesity Drugs
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Yin, X., Xu, Z., Zhang, X., Wu, J., & Lu, W. (2023) · Cell Cycle · doi:10.1080/15384101.2023.2169521 · Cited by 2
Targeting Thermogenesis in the Development of Antiobesity Drugs
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β3 Adrenergic Receptors as a Therapeutic Target for Obesity
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Senda, S., Inoue, A., Mahmood, A., Suzuki, R., Kamei, N., Kubota, N., Watanabe, T., Aoyama, M., Nawaz, A., Ohkuma, Y., et al. (2015) · Diabetology International · doi:10.1007/s13340-015-0205-3 · Cited by 2
The role of CREB in the liver and adipose tissue
Lee, D. (2014) · ScholarlyCommons (University of Pennsylvania) · Cited by 2
Özbek, N. E., Kılıç-Toprak, E., Çört, A., Altıntaş, F., Tokgün, O., & Küçükatay, V. (2025) · Pamukkale Medical Journal · doi:10.31362/patd.1667624 · Cited by 1
Vogel, H. G., Vogel, W. H., Schölkens, B. A., Sandow, J., Müller, G. A., & Vogel, W. F. (2002) · Springer eBooks · doi:10.1007/3-540-29837-1_13 · Cited by 1
Functional Anatomy of the ‘Adipose Organ’
Cinti, S. (2007) · Springer eBooks · doi:10.1007/978-88-470-0552-5_1 · Cited by 2
Gómez‐Hernández, A., Perdomo, L., Escribano, Ó., & Benito, M. (2013) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2012.11.002 · Cited by 1
G‐Protein‐Coupled Receptors as Drug Targets
Miao, W., & Wu, L. (2009) · doi:10.1002/9780470538951.ch20 · Cited by 1
TGF-β and Metabolic Homeostasis
Bennett, G., & Rane, S. G. (2013) · Springer eBooks · doi:10.1007/978-4-431-54409-8_18
Lee, Y.-H. (2012) · Human Biology
Cinti, S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1203-2_6
Teixeira, J. P. L. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/qkgy-km28
The roles of microRNAs in human mesenchymal stem cell adipogenesis
Annette, E. K. (2012) · Arrow@dit (Dublin Institute of Technology) · doi:10.13025/17714
Engineering Brown Adipose Tissue
McCartney, A. M. (2016)
Jean Himms-Hagen, D.Phil. (1933–2021): Pioneering research in brown adipose tissue thermogenesis
Harper, M., & Hagen, A. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00066.2022
Cinti, S., & Giordano, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-33832-9_13
Vettor, R., & Cinti, S. (2009) · Oxidative stress and disease · doi:10.1201/9781420091311.ch1
Fatty acid fate in determining oxidation and inflammation in adipose tissue
Mottillo, E. P. (2013) · Human Biology
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Farmer, S. R. (2010) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-642-13517-0_9
Zhang, R., Peng, G., Pan, X., & Tong, N. (2026) · Scientific Reports · doi:10.1038/s41598-026-45462-9
Herrera, C. L. (2015) · theses.fr (ABES) · doi:10.70675/d09d7e9cz079fz4faaz985aza9cd4fc18f18
Implications du microbiote intestinal et de la pectine dans la stéato-hépatite non-alcoolique
Houron, C. (2020) · theses.fr (ABES) · doi:10.70675/282e9d85z4f3dz4f5bz9045zd1ce6da72037
Assays of Anti-Obesity Activity
Herling, A. W. (2014) · Springer eBooks · doi:10.1007/978-3-319-05392-9_74
Metadata
- Authors
- Ghorbani, M., Claus, T. H., & Himms-Hagen, J.
- Affiliations
- University of Ottawa (CA)
- Wyeth (US)
- ORCID
- Ghorbani, Masoud
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 54
- Issue
- 1
- Pages
- 121-131
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W2041287325
- Cited by
- 195
- References
- 38
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 11 · 2018: 7 · 2017: 3 · 2016: 14 · 2015: 11 · 2014: 17 · 2013: 9 · 2012: 11
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- CL316,243, beta3-adrenergic agonists, brown adipocytes, brown adipose tissue, white adipose tissue, diet-induced obesity, obesity reversal, adipocyte hypertrophy, uncoupling proteins, thermogenesis, resting metabolic rate, high-fat diet, retroperitoneal adipose tissue, interscapular brown adipose tissue, adipocyte origin
- MeSH terms
- Uncoupling Protein 1, Adipose Tissue, Adrenergic beta-Agonists, Animals, Body Weight, Adipose Tissue, Brown, Carrier Proteins, Dietary Fats, Dioxoles, Epididymis, Hypertrophy, Immunohistochemistry, Ion Channels, Male, Membrane Proteins, Obesity, Organ Size, Receptors, Adrenergic, beta, Retroperitoneal Space, Rats, Sprague-Dawley, Receptors, Adrenergic, beta-3, Mitochondrial Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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