Cited by 196Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

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Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a β3-adrenoceptor agonist

Ghorbani, Masoud, Claus, Thomas H., Himms-Hagen, Jean·1997·Biochemical Pharmacology

DOI 10.1016/s0006-2952(97)00162-7

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Abstract

In a previous study, we demonstrated that chronic treatment with a new beta3-adrenoceptor agonist, CL 316,243 [disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-ben zodioxazole-2,2-dicarboxylate], promoted thermogenesis, caused the appearance of multilocular adipocytes in white adipose tissue (WAT), and retarded development of obesity in young rats eating a high-fat diet (Himms-Hagen et al., Am J Physiol 266: R1371-R1382, 1994). Objectives of the present study were to find out whether CL 316,243 could reverse established diet-induced obesity in rats and to identify the multilocular adipocytes that appeared in WAT. Infusion of CL 316,243 (1 mg/kg/day) reduced abdominal fat, with a decrease in enlarged adipocyte size but no loss of white adipocytes. The resting metabolic rate increased by 40-45%, but food intake was not altered. Abundant densely stained multilocular brown adipocytes expressing uncoupling protein (UCP) appeared in retroperitoneal WAT, in which a marked increase in protein content occurred. UCP content of interscapular brown adipose tissue (BAT) was also increased markedly. We suggest that the substantial increase in the resting metabolic rate induced by CL 316,243 occurs in brown adipocytes in both BAT and WAT. The origin of the brown adipocytes that appeared in WAT is uncertain. They may have been small brown preadipocytes, expressing beta3-adrenoceptors but with few mitochondria and little or no UCP, that were induced to hypertrophy by the beta3-agonist.

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Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,645
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FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,857
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Methods for the determination of adipose cell size in man and animals
Hirsch, J., & Gallian, E. (1968) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43151-7 · Cited by 894
Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization
Cousin, B., Cinti, S., Morroni, M., Raimbault, S., Ricquier, D., Pénicaud, L., & Casteilla, L. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.4.931 · Cited by 665
Handbook of obesity
Bray, G. A., & Bouchard, C. (1997) · CRC Press eBooks · Cited by 618
Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor γ
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1995) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(95)80025-5 · Cited by 462
Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats
Himms‐Hagen, J., Cui, J. Z., Danforth, E., Taatjes, D. J., Lang, S. S., Waters, B. L., & Claus, T. H. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.4.r1371 · Cited by 382
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Young, P., Arch, J. R. S., & Ashwell, M. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)80822-4 · Cited by 377
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Mantzoros, C. S., Frederich, R. C., Flier, J. S., Qu, D., Susulic, V. S., Lowell, B. B., & Maratos–Flier, E. (1996) · Diabetes · doi:10.2337/diab.45.7.909 · Cited by 314

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Authors: Ghorbani, M., Claus, T. H., & Himms-Hagen, J.
Affiliations: University of Ottawa (CA)
Wyeth (US)
ORCID: Ghorbani, Masoud
Venue: Biochemical Pharmacology
Publisher: Elsevier BV
Published: 1997-07
Volume: 54
Issue: 1
Pages: 121-131
ISSN: 0006-2952 (ISSN-L)
DOI: 10.1016/s0006-2952(97)00162-7
OpenAlex: W2041287325
Cited by: 195
References: 38
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 11 · 2018: 7 · 2017: 3 · 2016: 14 · 2015: 11 · 2014: 17 · 2013: 9 · 2012: 11
FWCI: 3.47
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: CL316,243, beta3-adrenergic agonists, brown adipocytes, brown adipose tissue, white adipose tissue, diet-induced obesity, obesity reversal, adipocyte hypertrophy, uncoupling proteins, thermogenesis, resting metabolic rate, high-fat diet, retroperitoneal adipose tissue, interscapular brown adipose tissue, adipocyte origin
MeSH terms: Uncoupling Protein 1, Adipose Tissue, Adrenergic beta-Agonists, Animals, Body Weight, Adipose Tissue, Brown, Carrier Proteins, Dietary Fats, Dioxoles, Epididymis, Hypertrophy, Immunohistochemistry, Ion Channels, Male, Membrane Proteins, Obesity, Organ Size, Receptors, Adrenergic, beta, Retroperitoneal Space, Rats, Sprague-Dawley, Receptors, Adrenergic, beta-3, Mitochondrial Proteins, Rats

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Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a β3-adrenoceptor agonist

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