CoChat
Sign Up
Cited by 165Neuroscience of respiration and sleepAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesHeart Rate Variability and Autonomic Control

Persistent respiratory irregularity in patients with panic disorder

Abelson, James L, Weg, John G, Nesse, Randolph M, Curtis, George C·2001·Biological Psychiatry
DOI 10.1016/s0006-3223(00)01078-7
Open this paper in CoChat — free account

Abstract

Background Dysregulated respiratory control may play a role in the pathophysiology of panic disorder. This could be due to abnormalities in brain stem respiratory nuclei or to dysregulation at higher brain levels. Results from previous studies using the doxapram model of panic have yielded an unclear picture. A brief cognitive manipulation reduced doxapram-induced hyperventilation in patients, suggesting that higher level inputs can substantially alter their respiratory patterns. However, respiratory abnormalities persisted, including a striking irregularity in breathing patterns. Methods To directly study respiratory irregularity, breath-by-breath records of tidal volume (V(t)) and frequency (f) from previously studied subjects were obtained. Irregularity was quantified using von Neumann's statistic and calculation of "sigh" frequency in 16 patients and 16 matched control subjects. Half of each group received a standard introduction to the study and half received a cognitive intervention designed to reduce anxiety/distress responses to the doxapram injection. Results Patients had significantly greater V(t) irregularity relative to control subjects. Neither the cognitive intervention nor doxapram-induced hyperventilation produced significant changes in V(t) irregularity. The V(t) irregularity was attributable to a sighing pattern of breathing that was characteristic of panic patients but not control subjects. Patients also had somewhat elevated f irregularity relative to cont…

Integrity signals

Registry

Crossref · 10.1016/s0006-3223(00)01078-7

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Panic disorder patients show increased variability in tidal volume and minute ventilation compared with controls.

    “Among the cross sectional findings supporting this hypothesis are increased variability in tidal volume and minute ventilation (Abelson et al., 2001; Wilhelm et al., 2001; Gorman et al., 1988; Caldirola et al., 2004)”

    From Feedback of end-tidal pCO2 as a therapeutic approach for panic disorder (2008) · cites this paper as Abelson et al., 2001

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Abelson, J. L., Weg, J. G., Nesse, R. M., & Curtis, G. C.
Affiliations
University of Michigan (US)
Corresponding author
Abelson, James L
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2001-04
Volume
49
Issue
7
Pages
588-595
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(00)01078-7
OpenAlex
W2024276621
Cited by
165
References
5
Citations by year
2026: 5 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 8 · 2015: 2 · 2014: 10 · 2013: 6 · 2012: 7
FWCI
2.93
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29mh052724-05)
  • National Institute of Mental Health (R29 MH52724)
  • National Center for Research Resources (M01RR000042)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
panic disorder, respiratory irregularity, tidal volume variability, sighs, cognitive intervention, anxiety, breathing pattern
MeSH terms
Adult, Analysis of Variance, Doxapram, Female, Humans, Hyperventilation, Male, Respiratory Physiological Phenomena, Cognitive Behavioral Therapy, Single-Blind Method, Panic Disorder, Treatment Outcome, Respiratory System Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review