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Cited by 134Suicide and Self-Harm StudiesTreatment of Major DepressionNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

MRI correlates of suicide attempt history in unipolar depression

Ahearn, Eileen P, Jamison, Kay R, Steffens, David C, Cassidy, Frederick, Provenzale, James M, Lehman, Ann, Weisler, Richard H, Carroll, Bernard J, Krishnan, K.Ranga Rama·2001·Biological Psychiatry
DOI 10.1016/s0006-3223(01)01098-8
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Abstract

Background Suicide represents a major health problem in the United States, and prediction of suicide attempts is difficult. No structural neuroimaging studies have been done to specifically examine findings in patients who have attempted suicide. The objective of this study was to compare MRI findings in unipolar patients with and without a history of a suicide attempt.Methods In this post hoc analysis, 20 unipolar subjects with a history of a suicide attempt were matched by age and gender to unipolar subjects without a history of an attempt. Subjects were also matched on parameters such as cardiovascular history, electroconvulsive treatment history, and history of psychosis. Subjects with a history of any neurologic condition were excluded. There were no significant differences in age of onset of depression, number of episodes of depression, and Hamilton Depression scores between the two groups. T2-weighted magnetic resonance imaging (MRI) scans were rated using the Coffey and Boyko rating scales.Results Unipolar patients with a history of a suicide attempt demonstrated significantly more subcortical gray matter hyperintensities compared with patients without such a history.Conclusions Patients with abnormal MRI findings may be at higher risk for mood disorders and suicide attempts because of disruption of critical neuroanatomic pathways. Gray matter hyperintensities in the basal ganglia may be especially associated with risk for suicide attempts.

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Research works printed but not linked: 5

  1. Boyko, 1994, Utility of post mortem magnetic resonance imaging in neuropathology, Arch Pathol Lab Med, 118, 219
  2. Cummings, 1993, The neuroanatomy of depression, J Clin Psychiatry, 54, 14
  3. Hrdina, 1995, Serotonergic markers in platelets of patients with major depression, J Psychiatry Neurosci, 20, 11
  4. Pandey, 1995, Platelet serotonin-2 receptors, Am J Psychiatry, 152, 850
  5. Weisler, 1998, Familial leukoencephalopathy in bipolar disorder, Am J Psychiatry, 155, 1605, 10.1176/ajp.155.11.1605 · DOI

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Metadata

Authors
Ahearn, E. P., Jamison, K. R., Steffens, D. C., Cassidy, F., Provenzale, J. M., Lehman, A., Weisler, R. H., Carroll, B. J., & Krishnan, K. R. R.
Affiliations
  • Duke University (US)
  • Johns Hopkins University (US)
  • Duke Medical Center (US)
  • SAS Institute (United States) (US)
Corresponding author
Ahearn, Eileen P
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2001-08
Volume
50
Issue
4
Pages
266-270
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(01)01098-8
OpenAlex
W1968131731
Cited by
133
References
41
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 4 · 2018: 22 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 16 · 2013: 7 · 2012: 6
FWCI
3.99
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (P30MH040159, P30 MH 40159)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
suicide attempt history, major depressive disorder, basal ganglia, T2-weighted MRI, suicide risk, mood disorders
MeSH terms
Aged, Brain, Depressive Disorder, Electroconvulsive Therapy, Female, Humans, Magnetic Resonance Imaging, Male, Suicide, Attempted

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