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Cited by 404Neuroendocrine regulation and behaviorAutism Spectrum Disorder ResearchNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Oxytocin and autistic disorder: alterations in peptide forms

Green, LeeAnne, Fein, Deborah, Modahl, Charlotte, Feinstein, Carl, Waterhouse, Lynn, Morris, Mariana·2001·Biological Psychiatry
DOI 10.1016/s0006-3223(01)01139-8
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Abstract

Background Oxytocin (OT) is synthesized as a prohormone that is sequentially processed to peptides. These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides, OT-Gly, OT-Gly-Lys and OT-Gly-Lys-Arg, which are designated together as OT-X. As an extension of our previous study finding decreased plasma OT in autism, studies were conducted to determine whether there were changes in OT peptide forms in autistic children.Methods Twenty eight male subjects (97 +/- 20 months; range, 70-139 months), diagnosed with DSM-IV autistic disorder through observation and semi-structured interview, were compared with 31 age-matched nonpsychiatric control subjects (106 +/- 22 months; range, 74-140 months). Using OT antisera with different specificity for the peptide forms, we measured plasma OT and OT-X in each group.Results T tests showed that there was a decrease in plasma OT (t = 4.4, p <.0001), an increase in OT-X (t = 2.3, p <.03) and an increase in the ratio of OT-X/OT (t = 4.5, p <.0001) in the autistic sample, compared with control subjects.Conclusions The results suggest that children with autistic disorder show alterations in the endocrine OT system. Deficits in OT peptide processing in children with autism may be important in the development of this syndrome.

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Research works printed but not linked: 3

  1. Lucot, 2000, Behavioral effects of stress in oxytocin knockout mice, Society for Neuroscience Abstracts, 26, 2042
  2. Rapin, 1996, Preschoolers with inadequate communication, Clin Dev Med, 139
  3. Swaab, 1995, Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (Putative satiety cells) in Prader-Willi Syndrome, J Clin Endocrinol Metab, 80, 573

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Metadata

Authors
Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M.
Affiliations
  • Wayne State University (US)
  • University of Connecticut (US)
  • University of California, Irvine Medical Center (US)
  • Stanford Medicine (US)
  • The College of New Jersey (US)
  • Wright State University (US)
Corresponding author
Morris, Mariana
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2001-10
Volume
50
Issue
8
Pages
609-613
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(01)01139-8
OpenAlex
W2018530860
Cited by
404
References
26
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 8 · 2022: 13 · 2021: 19 · 2020: 19 · 2019: 12 · 2018: 16 · 2017: 19 · 2016: 22 · 2015: 30 · 2014: 29 · 2013: 30 · 2012: 29
FWCI
13.69
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • NSUWorks (Nova Southeastern University) (submittedVersion)
Funders
  • National Institutes of Health (5r01hl043178-09)
  • National Heart, Lung, and Blood Institute (HL-43178)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
oxytocin, autistic disorder, autism spectrum disorder, plasma oxytocin, oxytocin receptor, children
MeSH terms
Adolescent, Autistic Disorder, Child, Child, Preschool, Humans, Male, Oxytocin, Personality Assessment, Protein Precursors, Reference Values

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