Cited by 404Neuroendocrine regulation and behaviorAutism Spectrum Disorder ResearchNeuropeptides and Animal Physiology

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Oxytocin and autistic disorder: alterations in peptide forms

Green, LeeAnne, Fein, Deborah, Modahl, Charlotte, Feinstein, Carl, Waterhouse, Lynn, Morris, Mariana·2001·Biological Psychiatry

DOI 10.1016/s0006-3223(01)01139-8

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Abstract

Background Oxytocin (OT) is synthesized as a prohormone that is sequentially processed to peptides. These peptides are the bioactive amidated form (OT) and the C-terminal extended peptides, OT-Gly, OT-Gly-Lys and OT-Gly-Lys-Arg, which are designated together as OT-X. As an extension of our previous study finding decreased plasma OT in autism, studies were conducted to determine whether there were changes in OT peptide forms in autistic children.Methods Twenty eight male subjects (97 +/- 20 months; range, 70-139 months), diagnosed with DSM-IV autistic disorder through observation and semi-structured interview, were compared with 31 age-matched nonpsychiatric control subjects (106 +/- 22 months; range, 74-140 months). Using OT antisera with different specificity for the peptide forms, we measured plasma OT and OT-X in each group.Results T tests showed that there was a decrease in plasma OT (t = 4.4, p <.0001), an increase in OT-X (t = 2.3, p <.03) and an increase in the ratio of OT-X/OT (t = 4.5, p <.0001) in the autistic sample, compared with control subjects.Conclusions The results suggest that children with autistic disorder show alterations in the endocrine OT system. Deficits in OT peptide processing in children with autism may be important in the development of this syndrome.

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RETRACTED: Effect of intranasal oxytocin administration on psychiatric symptoms: A meta-analysis of placebo-controlled studies
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Authors: Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M.
Affiliations: Wayne State University (US)
University of Connecticut (US)
University of California, Irvine Medical Center (US)
Stanford Medicine (US)
The College of New Jersey (US)
Wright State University (US)
Corresponding author: Morris, Mariana
ORCID: Fein, Deborah
Feinstein, Carl
Waterhouse, Lynn
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2001-10
Volume: 50
Issue: 8
Pages: 609-613
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(01)01139-8
OpenAlex: W2018530860
Cited by: 404
References: 26
Citations by year: 2026: 3 · 2025: 2 · 2024: 1 · 2023: 8 · 2022: 13 · 2021: 19 · 2020: 19 · 2019: 12 · 2018: 16 · 2017: 19 · 2016: 22 · 2015: 30 · 2014: 29 · 2013: 30 · 2012: 29
FWCI: 13.69
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
NSUWorks (Nova Southeastern University) (submittedVersion)
Funders: National Institutes of Health (5r01hl043178-09)
National Heart, Lung, and Blood Institute (HL-43178)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, autistic disorder, autism spectrum disorder, plasma oxytocin, oxytocin receptor, children
MeSH terms: Adolescent, Autistic Disorder, Child, Child, Preschool, Humans, Male, Oxytocin, Personality Assessment, Protein Precursors, Reference Values

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Oxytocin and autistic disorder: alterations in peptide forms

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