Rotating night shifts and risk of breast cancer in women participating in the nurses׳ health study
Open accessAbstract
BACKGROUND: Melatonin shows potential oncostatic action, and light exposure during night suppresses melatonin production. There is little information, however, about the direct effect of night work on the risk of cancer. We investigated the effect of night work in breast cancer. METHODS: We examined the relationship between breast cancer and working on rotating night shifts during 10 years of follow-up in 78 562 women from the Nurses' Health Study. Information was ascertained in 1988 about the total number of years during which the nurses had worked rotating night shifts with at least three nights per month. From June 1988 through May 1998, we documented 2441 incident breast cancer cases. Logistic regression models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs), adjusted for confounding variables and breast cancer risk factors. All statistical tests were two-sided. RESULTS: We observed a moderate increase in breast cancer risk among the women who worked 1-14 years or 15-29 years on rotating night shifts (multivariate adjusted RR = 1.08 [95% CI = 0.99 to 1.18] and RR = 1.08 [95% CI = 0.90 to 1.30], respectively). The risk was further increased among women who worked 30 or more years on the night shift (RR = 1.36; 95% CI = 1.04 to 1.78). The test for trend was statistically significant (P =.02). CONCLUSIONS: Women who work on rotating night shifts with at least three nights per month, in addition to days and evenings in that month, appear to have a moderately increased risk of breast cancer after extended periods of working rotating night shifts.
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Among women with ≥30 years of rotating night shift work, breast cancer mortality was non-significantly increased by 47% in the current study, somewhat consistent with a previous report in the same cohort describing a significant 36% increase in breast cancer incidence.
“Among women with ≥30 years of rotating night shift work, breast cancer mortality was non-significantly increased by 47% in the current study, which is somewhat consistent with a previous report in the same cohort14 describing a significant 36% increase in breast cancer incidence.”
From Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts (2015) · cites this paper as [14]
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Cites
Reproducibility and validity of a semiquantitative food frequency questionnaire
WILLETT, W. C., SAMPSON, L., STAMPFER, M. J., ROSNER, B., BAIN, C., WITSCHI, J., HENNEKENS, C. H., & SPEIZER, F. E. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114086 · Cited by 4,274 · see citing works
Self-citationLight Suppresses Melatonin Secretion in Humans
Lewy, A. J., Wehr, T. A., Goodwin, F. K., Newsome, D. A., & Markey, S. P. (1980) · Science · doi:10.1126/science.7434030 · Cited by 1,913 · see citing works
Brzezinski, A. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701163360306 · Cited by 1,549 · see citing works
Epidemiologic Analysis with a Programmable Calculator
Rothman, K. J., Boice, H. D., & Austin, H. D. (1982) · American Journal of Epidemiology · Cited by 1,041 · see citing works
COLDITZ, G. A., MARTIN, P., STAMPFER, M. J., WILLETT, W. C., SAMPSON, L., ROSNER, B., HENNEKENS, C. H., & SPEIZER, F. E. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114319 · Cited by 992 · see citing works
Self-citationA Prospective Study of Postmenopausal Estrogen Therapy and Coronary Heart Disease
Stampfer, M. J., Willett, W. C., Colditz, G. A., ROSNER, B. A., Speizer, F. E., & Hennekens, C. H. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510243131703 · Cited by 855 · see citing works
Self-citationD'Agostino, R. B., Lee, M., Belanger, A. J., Cupples, L. A., Anderson, K., & Kannel, W. B. (1990) · Statistics in Medicine · doi:10.1002/sim.4780091214 · Cited by 798 · see citing works
TEST OF THE NATIONAL DEATH INDEX
Stampfer, M. J., Willett, W. C., Speizer, F. E., DYSERT, D. C., LIPNICK, R. J., ROSNER, B. A., & Hennekens, C. H. (1984) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113804 · Cited by 791 · see citing works
Self-citationMelatonin receptors: Localization, molecular pharmacology and physiological significance
Morgan, P. J., Barrett, P., Howell, H. E., & Helliwell, R. J. A. (1994) · Neurochemistry International · doi:10.1016/0197-0186(94)90100-7 · Cited by 623 · see citing works
Dietary fat and the risk of breast cancer.
Willett, W. C., Stampfer, M. J., Colditz, G. A., Rosner, B. A., Hennekens, C. H., & Speizer, F. E. (1987) · New England Journal of Medicine · doi:10.1056/nejm198701013160105 · Cited by 534 · see citing works
Self-citationTest of the National Death Index and Equifax Nationwide Death Search
Rich-Edwards, J. W., Corsano, K. A., & Stampfer, M. J. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117191 · Cited by 530 · see citing works
Prospective study of shift work and risk of coronary heart disease in women
Kawachi, I., Colditz, G. A., Stampfer, M. J., Willett, W. C., Manson, J. E., Speizer, F. E., & Hennekens, C. H. (1995) · Circulation · doi:10.1161/01.cir.92.11.3178 · Cited by 524 · see citing works
Self-citationIncreased breast cancer risk among women who work predominantly at night
Hansen, J. (2001) · Epidemiology · doi:10.1097/00001648-200101000-00013 · Cited by 503 · see citing works
Tan, D., Manchester, L. C., Reiter, R. J., Plummer, B. F., Limson, J. L., Weintraub, S. T., & Qi, W. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00435-4 · Cited by 474 · see citing works
Melatonin receptors: Are there multiple subtypes?
Dubocovich, M. L. (1995) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)88978-6 · Cited by 409 · see citing works
DOES NONDIFFERENTIAL MISCLASSIFICATION OF EXPOSURE ALWAYS BIAS A TRUE EFFECT TOWARD THE NULL VALUE?
Dosemeci, M., Wacholder, S., & Lubin, J. H. (1990) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115716 · Cited by 406 · see citing works
Clark, G. M., Osborne, C. K., & McGuire, W. L. (1984) · Journal of Clinical Oncology · doi:10.1200/jco.1984.2.10.1102 · Cited by 391 · see citing works
Cantab, M. A. (1976) · PubMed · Cited by 356 · see citing works
Conservation of photoperiod-responsive mechanisms in humans
Wehr, T. A., Moul, D. E., Barbato, G., Giesen, H. A., Seidel, J. A., Barker, C., & Bender, C. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.265.4.r846 · Cited by 334 · see citing works
Incidence of breast cancer in Norwegian female radio and telegraph operators
Tynes, T., Hannevik, M., Andersen, A., Vistnes, A. I., & Haldorsen, T. (1996) · Cancer Causes & Control · doi:10.1007/bf00051295 · Cited by 261 · see citing works
ROLE OF PINEAL GLAND IN qTIOLOGY AND TREATMENT OF BREAST CANCER
COHEN, M. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92591-6 · Cited by 251 · see citing works
Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells.
Cos, S., Fernández, R., Güezmes, A., & Sánchez‐Barceló, E. J. (1998) · PubMed · Cited by 246 · see citing works
Do plasma melatonin concentrations decline with age?
Zeitzer, J. M., Daniels, J. E., Duffy, J. F., Klerman, E. B., Shanahan, T. L., Dijk, D.-J., & Czeisler, C. A. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00266-1 · Cited by 239 · see citing works
RELATIVE WEIGHT AND RISK OF BREAST CANCER AMONG PREMENOPAUSAL WOMEN
Willett, W. C., Browne, M. L., Bain, C. J., LIPNICK, R. J., Stampfer, M. J., ROSNER, B. A., Colditz, G. A., Hennekens, C. H., & Speizer, F. E. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114156 · Cited by 231 · see citing works
Self-citationIncidence of cancer among Finnish airline cabin attendants, 1967-92
Pukkala, E., Auvinen, A. P., & Wahlberg, G. (1995) · BMJ · doi:10.1136/bmj.311.7006.649 · Cited by 229 · see citing works
The melatonin hypothesis: electric power and breast cancer.
Stevens, R. G., & Davis, S. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104s1135 · Cited by 218 · see citing works
Photic Regulation of Melatonin in Humans: Ocular and Neural Signal Transduction
Brainard, G. C., Rollag, M. D., & Hanifin, J. P. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200608 · Cited by 217 · see citing works
Blask, D. E., Sauer, L. A., Dauchy, R. T., Holowachuk, E. W., Ruhoff, M. S., & Kopff, H. S. (1999) · PubMed · Cited by 198 · see citing works
Lane, D. P. (1994) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072911 · Cited by 195 · see citing works
Melatonin increases p53 and p21WAFl expression in MCF-7 human breast cancer cells in vitro
Mediavilla, M. D., Cos, S., & Sánchez‐Barceló, E. J. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00262-3 · Cited by 190 · see citing works
Electric power, pineal function, and the risk of breast cancer
Stevens, R. G., Davis, S., Thomas, D. B., Anderson, L. E., & Wilson, B. W. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.3.1740235 · Cited by 184 · see citing works
Short and Long-term Adjustment of Circadian Rhythms in ‘ Permanent ’ Night Nurses
Folkard, S., Monk, T. H., & Lobban, M. C. (1978) · Ergonomics · doi:10.1080/00140137808931782 · Cited by 160 · see citing works
Anisimov, V. V. (1997) · Carcinogenesis · doi:10.1093/carcin/18.8.1549 · Cited by 113 · see citing works
The oncostatic action of melatonin in an ovarian carcinoma cell line
Petranka, J. G., Baldwin, W. S., Biermann, J., Jayadev, S., Barrett, J. C., & Murphy, E. (1999) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1999.tb00574.x · Cited by 101 · see citing works
Inverse association between breast cancer incidence and degree of visual impairment in Finland
Verkasalo, P. K., Pukkala, ., Stevens, R. G., Ojamo, M., & Rudanko, S. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690544 · Cited by 98 · see citing works
Breast Cancer and Electromagnetic Fields—A Review
Caplan, L. S. (2000) · Annals of Epidemiology · doi:10.1016/s1047-2797(99)00043-5 · Cited by 88 · see citing works
van den Heiligenberg, S. M., Deprés-Brummer, P., Barbason, H., Claustrat, B., REYNES, M., & Lévi, F. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00210-6 · Cited by 85 · see citing works
Melatonin affects the metabolism of the β‐amyloid precursor protein in different cell types
Lahiri, D. K. (1999) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1999.tb00575.x · Cited by 83 · see citing works
Twenty-four-hour melatonin and core body temperature rhythms: their adaptation in night workers
Weibel, L., Spiegel, K., Gronfier, C., FOLLENIUS, M., & BRANDENBERGER, G. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.3.r948 · Cited by 81 · see citing works
Eck, K., Yuan, L., Duffy, L., Ram, P. T., Ayettey, S., Chen, I., Cohn, C., Reed, J., & Hill, S. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.357 · Cited by 81 · see citing works
Shiu, S. Y. W., Li, L., Xu, J. N., Pang, C. S.-F., Wong, J. T. Y., & Pang, S. F. (1999) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1999.tb00614.x · Cited by 72 · see citing works
Melatonin and Colon Carcinogenesis
Anisimov, V. N. (2001) · Springer eBooks · doi:10.1007/978-3-642-59512-7_11 · Cited by 61 · see citing works
Vician, M., Zeman, M., Herichová, I., Juráni, M., Blazicek, P., & Matis, P. (1999) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1999.tb00612.x · Cited by 57 · see citing works
Mocchegiani, E., Perissin, L., Santarelli, L., Tibaldi, A., Zorzet, S., Rapozzi, V., Giacconi, R., Bulian, D., & Giraldi, T. (1999) · International Journal of Immunopharmacology · doi:10.1016/s0192-0561(98)00067-8 · Cited by 52 · see citing works
Melatonin receptors in PC3 human prostate tumor cells
Gilad, E., Laufer, M., Matzkin, H., & Zisapel, N. (1999) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1999.tb00586.x · Cited by 52 · see citing works
Bartsch, C., Bartsch, H., Karenovics, A., Franz, H. B. G., Peiker, G., & Mecke, D. (1997) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1997.tb00335.x · Cited by 51 · see citing works
An evaluation of scheduled bright light and darkness on rotating shiftworkers: Trial and limitations
Budnick, L. D., Lerman, S. E., & Nicolich, M. J. (1995) · American Journal of Industrial Medicine · doi:10.1002/ajim.4700270602 · Cited by 43 · see citing works
Breast cancer in female flight attendants
Mawson, A. R. (1998) · The Lancet · doi:10.1016/s0140-6736(05)79582-9 · Cited by 39 · see citing works
Melatonin and colon carcinogenesis
Anisimov, V. N., Kvetnoy, I. M., Chumakova, N. K., Kvetnaia, T. V., Molotkov, A. O., Pogudina, N. A., Popovich, I. G., Васильевич, П. В., Zabezhinski, M. A., Bartsch, H., et al. (1999) · Experimental and Toxicologic Pathology · doi:10.1016/s0940-2993(99)80062-1 · Cited by 37 · see citing works
Musatov, S. A., Anisimov, V. N., André, V., Vigreux, C., Godard, T., & Sichel, F. (1999) · Cancer Letters · doi:10.1016/s0304-3835(98)00365-6 · Cited by 33 · see citing works
Electric Blanket Use and Breast Cancer in the Nurses' Health Study
Laden, F., Neas, L., Tolbert, P. E., Holmes, M. D., Hankinson, S. E., Spiegelman, D. L., Speizer, F. E., & Hunter, D. J. (2000) · American Journal of Epidemiology · doi:10.1093/aje/152.1.41 · Cited by 32 · see citing works
Self-citationAkbulut, H., İçlı, F., Büyükçelik, A., AKBULUT, K. G., & Demirci, S. (1999) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1999.tb00560.x · Cited by 30 · see citing works
Melatonin does not inhibit estradiol-stimulated proliferation in MCF-7 and BG-1 cells
Baldwin, W. S. (1998) · Carcinogenesis · doi:10.1093/carcin/19.11.1895 · Cited by 28 · see citing works
Bartsch, C., Kvetnoy, I. M., Kvetnaia, T. V., Bartsch, H., Molotkov, A. O., Franz, H. B. G., Райхлин, Н. Т., & Mecke, D. (1997) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1997.tb00340.x · Cited by 26 · see citing works
Bartsch, C., Bartsch, H., Buchberger, A., Stieglitz, A., Effenberger-Klein, A., Kruse-Jarres, J. D., Besenthal, I., Rokos, H., & Mecke, D. (1999) · Oncology · doi:10.1159/000011960 · Cited by 26 · see citing works
Kennaway, D. J., & Rowe, S. A. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.280103.x · Cited by 14 · see citing works
p53-independentWAF1 induction by ACNU in human glioblastoma cells
Aoki, H., Ohnishi, K., Wang, X., Takahashi, A., Ohnishi, T., Nakamura, M., & Sakaki, T. (1998) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199803)21:3 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Baldwin WS, Barrett JC. Melatonin: receptor- mediated events that may affect breast and other steroid hormone-dependent cancers. Mol Carcinog 1998;21:149-55.
- Blask DE, Sauer LA, Dauchy RT, Holowachuk EW, Ruhoff MS, Kopff HS. Melatonin inhibi- tion of cancer growth in vivo involves suppres- sion of tumor fatty acid metabolism via mela- tonin receptor-mediated signal. Cancer Res 1999;59:4693-701.
- D'Agostino RB, Lee ML, Belanger AJ, Cupples LA, Anderson K, Kannel WB. Rela- tion of pooled logistic regression to time de- pendent Cox regression analysis: the Framing- ham Heart Study. Stat Med 1990;9:1501-15.
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The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611 · see citing works
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,189 · see citing works
Carcinogenicity of shift-work, painting, and fire-fighting
Straif, K., Baan, R., Grosse, Y., Secretan, B., Ghissassi, F. E., Bouvard, V., Altieri, A., Benbrahim-Tallaa, L., & Cogliano, V. (2007) · The Lancet Oncology · doi:10.1016/s1470-2045(07)70373-x · Cited by 1,082 · see citing works
Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976 · see citing works
Night Shift Work, Light at Night, and Risk of Breast Cancer
Davis, S., Mirick, D. K., & Stevens, R. G. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1557 · Cited by 930 · see citing works
Depression and cancer: mechanisms and disease progression
Spiegel, D., & Giese-Davis, J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00566-3 · Cited by 874 · see citing works
Risk for and consequences of endometriosis: A critical epidemiologic review
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Akhtar, R. A., Reddy, A. B., Maywood, E. S., Clayton, J. D., King, V. M., Smith, A. G., Gant, T. W., Hastings, M. H., & Kyriacou, C. P. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00759-5 · Cited by 777 · see citing works
Touitou, Y., Reinberg, A., & Touitou, D. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.02.008 · Cited by 738 · see citing works
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Self-citationPhillips, A. J. K., Clerx, W. M., O’Brien, C. S., Sano, A., Barger, L. K., Picard, R. W., Lockley, S. W., Klerman, E. B., & Czeisler, C. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-03171-4 · Cited by 647 · see citing works
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Shift work and chronic disease: the epidemiological evidence
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“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript (Hansen, 2001; Kloog et al., 2009; Megdal et al., 2005; Schernhammer et al., 2006; Schernhammer et al., 2001; Viswanathan et al., 2007) or display poorer cancer prognosis (Lis et al., 2003).”
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Broad targeting of angiogenesis for cancer prevention and therapy
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Melatonin, sleep disturbance and cancer risk
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Blask, D. E., Brainard, G. C., Dauchy, R. T., Hanifin, J. P., Davidson, L. K., Krause, J. A., Sauer, L. A., Rivera-Bermudez, M. A., Dubocovich, M. L., Jasser, S. A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1945 · Cited by 431 · see citing works
Deregulated expression of the PER1 , PER2 and PER3 genes in breast cancers
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Stevens, R. G., Hansen, J., Costa, G., Haus, E., Kauppinen, T., Aronson, K. J., Castaño-Vinyals, G., Davis, S., Frings-Dresen, M. H. W., Fritschi, L., et al. (2011) · Occupational and Environmental Medicine · doi:10.1136/oem.2009.053512 · Cited by 421 · see citing works
Self-citationEffects of Chronic Jet Lag on Tumor Progression in Mice
Filipski, E., Delaunay, F., King, V. M., Wu, M., Claustrat, B., Gréchez‐Cassiau, A., Guettier, C., Hastings, M. H., & Lévi, F. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0674 · Cited by 416 · see citing works
Host Circadian Clock as a Control Point in Tumor Progression
Filipski, E. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.9.690 · Cited by 413 · see citing works
The emerging link between cancer, metabolism, and circadian rhythms
Masri, S., & Sassone‐Corsi, P. (2018) · Nature Medicine · doi:10.1038/s41591-018-0271-8 · Cited by 406 · see citing works
Kubo, T., Ozasa, K., Mikami, K., Wakai, K., Fujino, Y., Watanabe, Y., Miki, T., Nakao, M., Hayashi, K., Suzuki, K. A. O., et al. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj232 · Cited by 403 · see citing works
Pauley, S. M. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.03.020 · Cited by 394 · see citing works
Biological Clocks and Shift Work: Circadian Dysregulation and Potential Long-term Effects
Haus, E. L., & Smolensky, M. H. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-9015-4 · Cited by 391 · see citing works
Effects of Health Care Provider Work Hours and Sleep Deprivation on Safety and Performance
Lockley, S. W., Barger, L. K., Ayas, N., Rothschild, J. M., Czeisler, C. A., & Landrigan, C. P. (2007) · The Joint Commission Journal on Quality and Patient Safety · doi:10.1016/s1553-7250(07)33109-7 · Cited by 390 · see citing works
Arendt, J. (2006) · Chronobiology International · doi:10.1080/07420520500464361 · Cited by 383 · see citing works
The mammalian circadian timing system: from gene expression to physiology
Gachon, F., Nagoshi, E., Brown, S., Ripperger, J. A., & Schibler, U. (2004) · Chromosoma · doi:10.1007/s00412-004-0296-2 · Cited by 382 · see citing works
Circadian disruption in cancer: A neuroendocrine-immune pathway from stress to disease?
Sephton, S., & Spiegel, D. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00078-3 · Cited by 377 · see citing works
Epidemiology of Breast Cancer in Women
Coughlin, S. S. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-20301-6_2 · Cited by 363 · see citing works
Light-at-night, circadian disruption and breast cancer: assessment of existing evidence
Stevens, R. G. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp178 · Cited by 345 · see citing works
Biology, vulnerabilities and clinical applications of circulating tumour cells
Ring, A., Nguyen-Sträuli, B. D., WICKI, A. N., & Aceto, N. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00536-4 · Cited by 331 · see citing works
Melatonin: an inhibitor of breast cancer
Hill, S. M., Belancio, V. P., Dauchy, R. T., Xiang, S., Brimer, S., Mao, L., Hauch, A. T., Lundberg, P. W., Summers, W. M., Yuan, L., et al. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0030 · Cited by 322 · see citing works
Circadian Rhythm Disruption in Cancer Biology
Savvidis, C., & Koutsilieris, M. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00077 · Cited by 316 · see citing works
Trinkoff, A. M., Le, R., Geiger-Brown, J. M., Lipscomb, J. A., & Lang, G. M. (2006) · American Journal of Industrial Medicine · doi:10.1002/ajim.20330 · Cited by 309 · see citing works
The impact of daytime light exposures on sleep and mood in office workers
Figueiro, M. G., Steverson, B., Heerwagen, J., Kampschroer, K., Hunter, C. M., Gonzales, K., Plitnick, B., & Rea, M. S. (2017) · Sleep Health · doi:10.1016/j.sleh.2017.03.005 · Cited by 308 · see citing works
Davis, S., & Mirick, D. K. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-9010-9 · Cited by 302 · see citing works
Circadian Disruption and Breast Cancer
Stevens, R. G. (2005) · Epidemiology · doi:10.1097/01.ede.0000152525.21924.54 · Cited by 295 · see citing works
The inner clock-Blue light sets the human rhythm
Wahl, S., Engelhardt, M., Schaupp, P., Lappe, C., & Ivanov, I. V. (2019) · Journal of Biophotonics · doi:10.1002/jbio.201900102 · Cited by 293 · see citing works
Chronobiology, drug delivery, and chronotherapeutics
Smolensky, M. H., & Peppas, N. A. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.07.001 · Cited by 290 · see citing works
Circadian molecular clocks and cancer
Kelleher, F. C., Rao, A. D., & Maguire, A. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.09.040 · Cited by 276 · see citing works
Occupation and cancer in Britain
Rushton, L., Bagga, S., Bevan, R. J., Brown, T. P., Cherrie, J. W., Holmes, P., Fortunato, L., Slack, R. J., van Tongeren, M., Young, C., et al. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605637 · Cited by 267 · see citing works
The circadian clock in cancer development and therapy
Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251 · see citing works
Rotating Night-Shift Work and the Risk of Breast Cancer in the Nurses' Health Studies
Wegrzyn, L. R., Tamimi, R. M., Rosner, B. A., Brown, S. B., Stevens, R. G., Eliassen, A. H., Laden, F., Willett, W. C., Hankinson, S. E., & Schernhammer, E. S. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx140 · Cited by 258 · see citing works
Self-citationNight Work and the Risk of Cancer Among Men
Parent, M.-E., El-Zein, M., Rousseau, M.-C., Pintos, J., & Siemiatycki, J. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kws318 · Cited by 243 · see citing works
Innominato, P. F., Focan, C., Gorlia, T., Moreau, T., Garufi, C., Waterhouse, J. M., Giacchetti, S., Coudert, B. P., Iacobelli, S., Genet, D., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4747 · Cited by 246 · see citing works
Night-shift work and breast cancer – a systematic review and meta-analysis
Ijaz, S., Verbeek, J. H. A. M., Seidler, A., Lindbohm, M.-L., Ojajärvi, A., Orsini, N., Costa, G., & Neuvonen, K. (2013) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3371 · Cited by 243 · see citing works
Shift work and cancer – considerations on rationale, mechanisms, and epidemiology
Costa, G., Haus, E., & Stevens, R. (2010) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.2899 · Cited by 241 · see citing works
Considerations for lighting in the built environment: Non-visual effects of light
Webb, A. R. (2006) · Energy and Buildings · doi:10.1016/j.enbuild.2006.03.004 · Cited by 240 · see citing works
Light at Night, Chronodisruption, Melatonin Suppression, and Cancer Risk: A Review
Reiter, R. J., Tan, D., Korkmaz, A., Erren, T. C., Piekarski, C., Tamura, H., & Manchester, L. C. (2007) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.v13.i4.30 · Cited by 240 · see citing works
Min, J., Kim, Y., Lee, S.-J., Jang, T. W., Kim, I., & Song, J. (2019) · Safety and Health at Work · doi:10.1016/j.shaw.2019.09.005 · Cited by 252 · see citing works
Kloog, I., Haim, A., Stevens, R. G., Barchana, M., & Portnov, B. A. (2008) · Chronobiology International · doi:10.1080/07420520801921572 · Cited by 233 · see citing works
Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure
Bonmatí‐Carrión, M., Argüelles-Prieto, R., Martínez-Madrid, M. J., Reiter, R. J., Hardeland, R., Rol, M. A., & Madrid, J. A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151223448 · Cited by 238 · see citing works
Night shift work at specific age ranges and chronic disease risk factors
Ramin, C., Devore, E. E., Wang, W., Pierre-Paul, J., Wegrzyn, L. R., & Schernhammer, E. S. (2015) · Occupational and Environmental Medicine · doi:10.1136/oemed-2014-102292 · Cited by 228 · see citing works
Self-citationMansukhani, M. P., Kolla, B. P., Surani, S., Varon, J., & Ramar, K. (2012) · Postgraduate Medicine · doi:10.3810/pgm.2012.07.2583 · Cited by 227 · see citing works
Case–control study of shift-work and breast cancer risk in Danish nurses: Impact of shift systems
Hansen, J., & Stevens, R. G. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2011.07.005 · Cited by 226 · see citing works
Chronobiology in the endocrine system
Haus, E. L. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.01.001 · Cited by 222 · see citing works
Women's sleep in health and disease
Dzaja, A., Arber, S., Hislop, J., Kerkhofs, M., Kopp, C., Pollmächer, T., Polo‐Kantola, P., Skene, D. J., Stenuit, P., Tobler, I., et al. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.05.008 · Cited by 223 · see citing works
Hadadi, É., Taylor, W. R., Li, X., Aslan, Y., Vilotte, M., Rivière, J., Duvallet, G., Auriau, C., Dulong, S., Raymond‐Letron, I., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16890-6 · Cited by 223 · see citing works
Reddy, A. B., Field, M. D., Maywood, E. S., & Hastings, M. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07326.2002 · Cited by 220 · see citing works
Glucocorticoids as Entraining Signals for Peripheral Circadian Oscillators
Pezük, P., Mohawk, J. A., Wang, L. A., & Menaker, M. (2012) · Endocrinology · doi:10.1210/en.2012-1486 · Cited by 217 · see citing works
Sleep duration and the risk of prostate cancer: the Ohsaki Cohort Study
Kakizaki, M., Inoue, K., Kuriyama, S., Sone, T., Matsuda‐Ohmori, K., Nakaya, N., Fukudo, S., & Tsuji, I. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604425 · Cited by 216 · see citing works
Hansen, J., & Lassen, C. F. (2012) · Occupational and Environmental Medicine · doi:10.1136/oemed-2011-100240 · Cited by 214 · see citing works
Epidemiology of Urinary Melatonin in Women and Its Relation to Other Hormones and Night Work
Schernhammer, E. S., ROSNER, B. A., Willett, W. C., Laden, F., Colditz, G. A., & Hankinson, S. E. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.936.13.6 · Cited by 214 · see citing works
Self-citationNurses' Work Schedule Characteristics, Nurse Staffing, and Patient Mortality
Trinkoff, A. M., Johantgen, M., Storr, C. L., Gurses, A. P., Liang, Y., & Han, K. (2011) · Nursing Research · doi:10.1097/nnr.0b013e3181fff15d · Cited by 208 · see citing works
Influence of light at night on murine anxiety- and depressive-like responses
Fonken, L. K., Finy, M. S., Walton, J. C., Weil, Z. M., Workman, J. L., Ross, J., & Nelson, R. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.001 · Cited by 209 · see citing works
Shift Work, Jet Lag, and Female Reproduction
Mahoney, M. M. (2010) · International Journal of Endocrinology · doi:10.1155/2010/813764 · Cited by 209 · see citing works
Circadian dysfunction in disease
Bechtold, D. A., Gibbs, J. E., & Loudon, A. S. I. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.01.002 · Cited by 206 · see citing works
Kolstad, H. A. (2008) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.1194 · Cited by 208 · see citing works
Night-shift work and risk of breast cancer: a systematic review and meta-analysis
Kamdar, B. B., Tergas, A. I., Mateen, F. J., Bhayani, N. H., & Oh, J. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2433-1 · Cited by 209 · see citing works
Work Schedule, Needle Use, and Needlestick Injuries Among Registered Nurses
Trinkoff, A. M., Le, R., Geiger-Brown, J., & Lipscomb, J. (2007) · Infection Control & Hospital Epidemiology · doi:10.1086/510785 · Cited by 199 · see citing works
Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts
Gu, F., Han, J., Laden, F., Pan, A., Caporaso, N. E., Stampfer, M. J., Kawachi, I., Rexrode, K. M., Willett, W. C., Hankinson, S. E., et al. (2015) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2014.10.018 · Cited by 202 · see citing works
Self-citationEffects of light and food schedules on liver and tumor molecular clocks in mice
Filipski, E., Innominato, P. F., Wu, M., Li, X.-M., Iacobelli, S., Xian, L.-J., & Levi, F. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji083 · Cited by 200 · see citing works
Dim nighttime light impairs cognition and provokes depressive-like responses in a diurnal rodent
Fonken, L. K., Kitsmiller, E., Smale, L., & Nelson, R. J. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730412448324 · Cited by 203 · see citing works
Methodological Aspects of Shift-Work Research
Knutsson, A. (2004) · Chronobiology International · doi:10.1081/cbi-200038525 · Cited by 203 · see citing works
Human circadian rhythms: physiological and therapeutic relevance of light and melatonin
Skene, D. J., & Arendt, J. (2006) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/000456306778520142 · Cited by 201 · see citing works
A prospective study of sleep duration and pneumonia risk in women
Patel, S. R., Malhotra, A., Gao, X., Hu, F. B., Neuman, M. I., & Fawzi, W. W. (2012) · Sleep · doi:10.5665/sleep.1594 · Cited by 195 · see citing works
A meta-analysis on dose–response relationship between night shift work and the risk of breast cancer
Wang, F., Yeung, K.-W., Chan, W. C., Kwok, C. C.-H., Leung, S.-L., Wu, Ç., Chan, E. Y. Y., Yu, I. T.-S., Yang, X. R., & Tse, L. A. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt283 · Cited by 197 · see citing works
Markus, R. P., Fernandes, P. A. C. M., Kinker, G. S., Cruz‐Machado, S. D. S., & Marçola, M. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14083 · Cited by 196 · see citing works
Travis, R. C., Balkwill, A., Fensom, G. K., Appleby, P. N., Reeves, G. K., Wang, X.-S., Roddam, A. W., Gathani, T., Peto, R., Green, J., et al. (2016) · Journal of the National Cancer Institute · doi:10.1093/jnci/djw169 · Cited by 192 · see citing works
Melatonin in Cancer Management: Progress and Promise
Jung, B., & Ahmad, N. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1776 · Cited by 197 · see citing works
Sleep duration and the risk of breast cancer: the Ohsaki Cohort Study
Kakizaki, M., Kuriyama, S., Sone, T., Ohmori-Matsuda, K., Hozawa, A., Nakaya, N., Fukudo, S., & Tsuji, I. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604684 · Cited by 187 · see citing works
Estrogen receptor alpha phosphorylation and its functional impact in human breast cancer
Anbalagan, M., & Rowan, B. G. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.01.016 · Cited by 196 · see citing works
CLOCK in Breast Tumorigenesis: Genetic, Epigenetic, and Transcriptional Profiling Analyses
Hoffman, A. E., Yi, C., Zheng, T., Stevens, R. G., Leaderer, D., Zhang, Y., Holford, T. R., Hansen, J., Paulson, J., & Zhu, Y. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3798 · Cited by 192 · see citing works
Loss of cryptochrome reduces cancer risk in p53 mutant mice
Öztürk, N., Lee, J. H., Gaddameedhi, S., & Sancar, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813028106 · Cited by 192 · see citing works
Impact of Shift Work on the Health and Safety of Nurses and Patients
Berger, A. M., & Hobbs, B. (2006) · Clinical journal of oncology nursing · doi:10.1188/06.cjon.465-471 · Cited by 191 · see citing works
Circadian nature of immune function
Logan, R. W., & Sarkar, D. K. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.039 · Cited by 189 · see citing works
Circulating tumor cells: from new biological insights to clinical practice
Gu, X., Wei, S., & Lv, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01938-6 · Cited by 195 · see citing works
Breast cancer and night work among Norwegian nurses
Lie, J.-A. S., Roessink, J., & Kjærheim, K. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-3639-2 · Cited by 188 · see citing works
Mutation Research/Reviews in Mutation Research
Stevens, R. G. (2009) · Cited by 188 · see citing works
- Authors
- Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I., & Colditz, G. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Schernhammer, E. S.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-10-17
- Volume
- 93
- Issue
- 20
- Pages
- 1563-1568
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2142622103
- Cited by
- 1,142
- References
- 57
- Citations by year
- 2026: 18 · 2025: 22 · 2024: 34 · 2023: 27 · 2022: 38 · 2021: 42 · 2020: 54 · 2019: 50 · 2018: 40 · 2017: 60 · 2016: 51 · 2015: 60 · 2014: 55 · 2013: 79 · 2012: 77
- FWCI
- 40.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Cancer Institute (CA-87969, P01CA087969)
- National Institute of Environmental Health Sciences (ES62984)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- rotating night shifts, breast cancer risk, night work, melatonin, light exposure, nurses, occupational cancer risk
- MeSH terms
- Adult, Breast Neoplasms, Circadian Rhythm, Female, Follow-Up Studies, Humans, Light, Lighting, Melatonin, Middle Aged, Nurses, Pineal Gland, Surveys and Questionnaires, Risk, Risk Factors, Secretory Rate, Work Schedule Tolerance, Cohort Studies, Multicenter Studies as Topic, Incidence, Premenopause, Postmenopause
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